HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme.

abstract：:Myosin phosphatase-targeting subunit 1 (MYPT1) binds to the catalytic subunit of protein phosphatase 1 (PP1C). This binding is believed to target PP1C to specific substrates including myosin II, thus controlling cellular contractility. Surprisingly, we found that during mitosis, mammalian MYPT1 binds to polo-like kina...

journal_title：Developmental cell

authors： Yamashiro S,Yamakita Y,Totsukawa G,Goto H,Kaibuchi K,Ito M,Hartshorne DJ,Matsumura F

更新日期：2008-05-01 00:00:00

abstract：:The chemokine CXCL12 and its receptor CXCR4 have many functions during embryonic and post-natal life. We used murine models to investigate the role of CXCL12/CXCR4 signaling in cardiac development and found that embryonic Cxcl12-null hearts lacked intra-ventricular coronary arteries (CAs) and exhibited absent or mispl...

journal_title：Developmental cell

authors： Ivins S,Chappell J,Vernay B,Suntharalingham J,Martineau A,Mohun TJ,Scambler PJ

更新日期：2015-05-26 00:00:00

abstract：:Smad4 is a central intracellular effector of TGF-beta signaling. Smad-independent TGF-beta pathways, such as those mediated by p38 MAPK, have been identified in cell culture systems, but their in vivo functional mechanisms remain unclear. In this study, we investigated the role of TGF-beta signaling in tooth and palat...

journal_title：Developmental cell

authors： Xu X,Han J,Ito Y,Bringas P Jr,Deng C,Chai Y

更新日期：2008-08-01 00:00:00

abstract：:A remarkable feature of development is its reproducibility, the ability to correct embryo-to-embryo variations and instruct precise patterning. In Drosophila, embryonic patterning along the anterior-posterior axis is controlled by the morphogen gradient Bicoid (Bcd). In this article, we describe quantitative studies o...

journal_title：Developmental cell

authors： He F,Wen Y,Deng J,Lin X,Lu LJ,Jiao R,Ma J

更新日期：2008-10-01 00:00:00

abstract：:Changes in the genetic makeup of an organism can extend lifespan significantly if they promote tolerance to environmental insults and thus prevent the general deterioration of cellular function that is associated with aging. Here, we introduce the Jun N-terminal kinase (JNK) signaling pathway as a genetic determinant ...

journal_title：Developmental cell

authors： Wang MC,Bohmann D,Jasper H

更新日期：2003-11-01 00:00:00

abstract：:Cells in a variety of developmental contexts sense extracellular cues that are given locally on their surfaces, and subsequently amplify the initial signal to achieve cell polarization. Drosophila wing cells acquire planar polarity along the proximal-distal (P-D) axis, in which the amplification of the presumptive cue...

journal_title：Developmental cell

authors： Shimada Y,Yonemura S,Ohkura H,Strutt D,Uemura T

更新日期：2006-02-01 00:00:00

abstract：:Tissues have a natural capacity to replace dying cells and to heal wounds. This ability resides in resident stem cells, which self-renew, preserve, and repair their tissue during homeostasis and following injury. The skin epidermis and its appendages are subjected to daily assaults from the external environment. A hig...

journal_title：Developmental cell

authors： Gonzales KAU,Fuchs E

更新日期：2017-11-20 00:00:00

abstract：:During early embryonic development, cells are organized as cohesive epithelial sheets that are continuously growing and remodeled without losing their integrity, giving rise to a wide array of tissue shapes. Here, using live imaging in chick embryo, we investigate how epithelial cells rearrange during gastrulation. We...

journal_title：Developmental cell

authors： Firmino J,Rocancourt D,Saadaoui M,Moreau C,Gros J

更新日期：2016-02-08 00:00:00

abstract：:Neuroblastomas are associated with KIF1Bβ mutations within tumor suppressor region 1p36. In this issue of Developmental Cell, Li et al. (2016) show that KIF1Bβ binding releases calcineurin autoinhibition, leading to dephosphorylation of the DRP1 GTPase and subsequent mitochondrial fragmentation. KIF1Bβ impairment caus...

journal_title：Developmental cell

authors： Blackstone C

更新日期：2016-01-25 00:00:00

abstract：:The serine threonine kinase Akt is a core survival factor that underlies a variety of human diseases. Although regulatory phosphorylation and dephosphorylation have been well documented, the other posttranslational mechanisms that modulate Akt activity remain unclear. We show here that tetratricopeptide repeat domain ...

journal_title：Developmental cell

authors： Suizu F,Hiramuki Y,Okumura F,Matsuda M,Okumura AJ,Hirata N,Narita M,Kohno T,Yokota J,Bohgaki M,Obuse C,Hatakeyama S,Obata T,Noguchi M

更新日期：2009-12-01 00:00:00

abstract：:Caspase proteases execute apoptosis but also function in development. In this issue of Developmental Cell, Weaver et al. report that C. elegans CED-3 caspase promotes animal growth through PMK-1/p38 kinase cleavage, and at the expense of pathogen and stress immunity, revealing an unexpected homeostatic relationship be...

journal_title：Developmental cell

authors： Yarychkivska O,Shaham S

更新日期：2020-05-04 00:00:00

abstract：:Piwi family protein Aubergine (Aub) maintains genome integrity in late germ cells of the Drosophila ovary through Piwi-associated RNA-mediated repression of transposon activities. Although it is highly expressed in germline stem cells (GSCs) and early progeny, it remains unclear whether it plays any roles in early GSC...

journal_title：Developmental cell

authors： Ma X,Zhu X,Han Y,Story B,Do T,Song X,Wang S,Zhang Y,Blanchette M,Gogol M,Hall K,Peak A,Anoja P,Xie T

更新日期：2017-04-24 00:00:00

abstract：:Precise cell division control is critical for developmental patterning. For the differentiation of a functional stoma, a cellular valve for efficient gas exchange, the single symmetric division of an immediate precursor is absolutely essential. Yet, the mechanism governing this event remains unclear. Here we report co...

journal_title：Developmental cell

authors： Han SK,Qi X,Sugihara K,Dang JH,Endo TA,Miller KL,Kim ED,Miura T,Torii KU

更新日期：2018-05-07 00:00:00

abstract：:Because mitochondria have outer and inner membranes, the fusion of two mitochondria requires the coordinated fusion of four lipid bilayers. Fusion of the outer membranes requires mitofusins. A new study published in Cell (Meeusen et al., 2006) shows that inner membrane fusion requires the dynamin-related protein Mgm1/...

journal_title：Developmental cell

authors： Chan DC

更新日期：2006-11-01 00:00:00

abstract：:Pancreatic beta cells have been shown to be heterogeneous at multiple levels. However, spatially interrogating transcriptional heterogeneity in the intact tissue has been challenging. Here, we developed an optimized protocol for single-molecule transcript imaging in the intact pancreas and used it to identify a sub-po...

journal_title：Developmental cell

authors： Farack L,Golan M,Egozi A,Dezorella N,Bahar Halpern K,Ben-Moshe S,Garzilli I,Tóth B,Roitman L,Krizhanovsky V,Itzkovitz S

更新日期：2019-01-07 00:00:00

abstract：:The proper positioning of organs during development is essential, yet little is known about the regulation of this process in mammals. Using murine tooth development as a model, we have found that cell migration plays a central role in positioning of the organ primordium. By combining lineage tracing, genetic cell abl...

journal_title：Developmental cell

authors： Prochazka J,Prochazkova M,Du W,Spoutil F,Tureckova J,Hoch R,Shimogori T,Sedlacek R,Rubenstein JL,Wittmann T,Klein OD

更新日期：2015-12-21 00:00:00

abstract：:Tissue folding is a fundamental process that shapes epithelia into complex 3D organs. The initial positioning of folds is the foundation for the emergence of correct tissue morphology. Mechanisms forming individual folds have been studied, but the precise positioning of folds in complex, multi-folded epithelia is less...

journal_title：Developmental cell

authors： Tozluoǧlu M,Duda M,Kirkland NJ,Barrientos R,Burden JJ,Muñoz JJ,Mao Y

更新日期：2019-11-04 00:00:00

abstract：:The NAD+-dependent deacetylase Sirtuin 1 (SIRT1) is down-regulated in triple-negative breast cancer. To determine the mechanistic basis by which reduced SIRT1 expression influences processes related to certain aggressive cancers, we examined the consequences of depleting breast cancer cells of SIRT1. We discovered tha...

journal_title：Developmental cell

authors： Latifkar A,Ling L,Hingorani A,Johansen E,Clement A,Zhang X,Hartman J,Fischbach C,Lin H,Cerione RA,Antonyak MA

更新日期：2019-05-06 00:00:00

abstract：:Genome condensation during mitosis presents a chromatin landscape largely inaccessible to RNA polymerase II and most transcription factors. Caravaca et al. (2013) now report in Genes and Development that the pioneer transcription factor FOXA1 is retained at mitotic chromosomes, bookmarking the genome to enable gene ex...

journal_title：Developmental cell

authors： Rada-Iglesias A

更新日期：2013-02-25 00:00:00

abstract：:BMP signaling is essential for promoting self-renewal of mouse embryonic stem cells and Drosophila germline stem cells and for repressing stem cell proliferation in the mouse intestine and skin. However, it remains unknown whether BMP signaling can promote self-renewal of adult somatic stem cells. In this study, we sh...

journal_title：Developmental cell

authors： Kirilly D,Spana EP,Perrimon N,Padgett RW,Xie T

更新日期：2005-11-01 00:00:00

abstract：:In vitro, topographical and biophysical cues arising from the extracellular matrix (ECM) direct skeletal stem cell (SSC) commitment and differentiation. However, the mechanisms by which the SSC-ECM interface is regulated and the outcome of such interactions on stem cell fate in vivo remain unknown. Here we demonstrate...

journal_title：Developmental cell

authors： Tang Y,Rowe RG,Botvinick EL,Kurup A,Putnam AJ,Seiki M,Weaver VM,Keller ET,Goldstein S,Dai J,Begun D,Saunders T,Weiss SJ

更新日期：2013-05-28 00:00:00

abstract：:Bacteria display an array of contact-dependent interaction systems that have evolved to facilitate direct cell-to-cell communication. We have previously identified a mode of bacterial communication mediated by nanotubes bridging neighboring cells. Here, we elucidate nanotube architecture, dynamics, and molecular compo...

journal_title：Developmental cell

authors： Dubey GP,Malli Mohan GB,Dubrovsky A,Amen T,Tsipshtein S,Rouvinski A,Rosenberg A,Kaganovich D,Sherman E,Medalia O,Ben-Yehuda S

更新日期：2016-02-22 00:00:00

abstract：:Signaling receptors are internalized and regulated by clathrin-mediated endocytosis (CME). Two clathrin light chain isoforms, CLCa and CLCb, are integral components of the endocytic machinery whose differential functions remain unknown. We report that CLCb is specifically upregulated in non-small-cell lung cancer (NSC...

journal_title：Developmental cell

authors： Chen PH,Bendris N,Hsiao YJ,Reis CR,Mettlen M,Chen HY,Yu SL,Schmid SL

更新日期：2017-02-06 00:00:00

abstract：:The spinal cord and mesodermal tissues of the trunk such as the vertebral column and skeletal musculature derive from neuro-mesodermal progenitors (NMPs). Sox2, Brachyury (T), and Tbx6 have been correlated with NMP potency and lineage choice; however, their exact role and interaction in these processes have not yet be...

journal_title：Developmental cell

authors： Koch F,Scholze M,Wittler L,Schifferl D,Sudheer S,Grote P,Timmermann B,Macura K,Herrmann BG

更新日期：2017-09-11 00:00:00

abstract：:Translation of ribosomal protein-coding mRNAs (RP-mRNAs) constitutes a key step in ribosome biogenesis, but the mechanisms that modulate RP-mRNA translation in coordination with other cellular processes are poorly defined. Here, we show that subcellular localization of RP-mRNAs acts as a key regulator of their transla...

journal_title：Developmental cell

authors： Dermit M,Dodel M,Lee FCY,Azman MS,Schwenzer H,Jones JL,Blagden SP,Ule J,Mardakheh FK

更新日期：2020-11-09 00:00:00

abstract：:Asymmetric cell divisions generate cellular diversity. In Drosophila, embryonic neuroblasts target cell fate determinants basally, rotate their spindles by 90 degrees to align with the apical-basal axis, and divide asymmetrically in a stem cell-like fashion. In this process, apically localized Bazooka recruits Inscute...

journal_title：Developmental cell

authors： Petritsch C,Tavosanis G,Turck CW,Jan LY,Jan YN

更新日期：2003-02-01 00:00:00

abstract：:Cell locomotion entails functional and structural cooperation between cell surface adhesion and the actin cytoskeleton. A new paper by DeMali et al. provides new insights into the link between actin assembly and integrin adhesion at the leading edges of migrating cells. ...

journal_title：Developmental cell

authors： Kovacs EM,Yap AS

更新日期：2002-12-01 00:00:00

abstract：:In Drosophila, commitment of a cell to a sense organ precursor (SOP) fate requires bHLH proneural transcription factor upregulation, a process that depends in most cases on the interplay of proneural gene autoregulation and inhibitory Notch signaling. A subset of SOPs are selected by a recruitment pathway involving EG...

journal_title：Developmental cell

authors： zur Lage PI,Powell LM,Prentice DR,McLaughlin P,Jarman AP

更新日期：2004-11-01 00:00:00

abstract：:Mutations in Pkd1, encoding polycystin-1 (PC1), cause autosomal-dominant polycystic kidney disease (ADPKD). We show that the carboxy-terminal tail (CTT) of PC1 is released by γ-secretase-mediated cleavage and regulates the Wnt and CHOP pathways by binding the transcription factors TCF and CHOP, disrupting their intera...

journal_title：Developmental cell

authors： Merrick D,Chapin H,Baggs JE,Yu Z,Somlo S,Sun Z,Hogenesch JB,Caplan MJ

更新日期：2012-01-17 00:00:00

abstract：:Wingless (Wg) is a morphogen required for the patterning of many Drosophila tissues. Several lines of evidence implicate heparan sulfate-modified proteoglycans (HSPGs) such as Dally-like protein (Dlp) in the control of Wg distribution and signaling. We show that dlp is required to limit Wg levels in the matrix, contra...

journal_title：Developmental cell

authors： Kirkpatrick CA,Dimitroff BD,Rawson JM,Selleck SB

更新日期：2004-10-01 00:00:00