Probing intrinsic properties of a robust morphogen gradient in Drosophila.

abstract：:Renewing tissues have the remarkable ability to continually produce both proliferative progenitor and specialized differentiated cell types. How are complex milieus of microenvironmental signals interpreted to coordinate tissue-cell-type composition? Here, we investigate the responses of intestinal epithelium to indiv...

journal_title：Developmental cell

authors： Sanman LE,Chen IW,Bieber JM,Steri V,Trentesaux C,Hann B,Klein OD,Wu LF,Altschuler SJ

更新日期：2021-01-15 00:00:00

abstract：:TC10, a Rho family GTPase, has been shown to play an important role in the exocytosis of GLUT4 and other proteins, primarily by tethering the vesicles at the plasma membrane. Using a newly developed probe based on fluorescence resonance energy transfer, we found that TC10 activity at tethered vesicles dropped immediat...

journal_title：Developmental cell

authors： Kawase K,Nakamura T,Takaya A,Aoki K,Namikawa K,Kiyama H,Inagaki S,Takemoto H,Saltiel AR,Matsuda M

更新日期：2006-09-01 00:00:00

abstract：:Mbl is a bacterial actin homolog that controls cell morphogenesis in Bacillus subtilis. A functional GFP-Mbl fusion protein was used to examine the behavior of the helical cables formed by Mbl protein in live B. subtilis cells. The cables undergo dynamic changes during cell cycle progression. They are stable but not r...

journal_title：Developmental cell

authors： Carballido-López R,Errington J

更新日期：2003-01-01 00:00:00

abstract：:Recent data indicate that cystic fibrosis (CF) airway mucus is anaerobic. This suggests that Pseudomonas aeruginosa infection in CF reflects biofilm formation and persistence in an anaerobic environment. P. aeruginosa formed robust anaerobic biofilms, the viability of which requires rhl quorum sensing and nitric oxide...

journal_title：Developmental cell

authors： Yoon SS,Hennigan RF,Hilliard GM,Ochsner UA,Parvatiyar K,Kamani MC,Allen HL,DeKievit TR,Gardner PR,Schwab U,Rowe JJ,Iglewski BH,McDermott TR,Mason RP,Wozniak DJ,Hancock RE,Parsek MR,Noah TL,Boucher RC,Hassett DJ

更新日期：2002-10-01 00:00:00

abstract：:Airway smooth muscle is best known for its role as an airway constrictor in diseases such as asthma. However, its function in lung development is debated. A prevalent model, supported by in vitro data, posits that airway smooth muscle promotes lung branching through peristalsis and pushing intraluminal fluid to branch...

journal_title：Developmental cell

authors： Young RE,Jones MK,Hines EA,Li R,Luo Y,Shi W,Verheyden JM,Sun X

更新日期：2020-04-06 00:00:00

abstract：:Cell-to-cell communication coordinates the behavior of individual cells to establish organ patterning and development. Although mobile signals are known to be important in lateral root development, the role of plasmodesmata (PD)-mediated transport in this process has not been investigated. Here, we show that changes i...

journal_title：Developmental cell

authors： Benitez-Alfonso Y,Faulkner C,Pendle A,Miyashima S,Helariutta Y,Maule A

更新日期：2013-07-29 00:00:00

abstract：:We have used Drosophila ovarian follicle stem cells (FSCs) to study how stem cells are regulated by external signals and draw three main conclusions. First, the spatial definition of supportive niche positions for FSCs depends on gradients of Hh and JAK-STAT pathway ligands, which emanate from opposite, distant sites....

journal_title：Developmental cell

authors： Vied C,Reilein A,Field NS,Kalderon D

更新日期：2012-10-16 00:00:00

abstract：:To ensure equal chromosome segregation during mitosis, the macromolecular kinetochore must remain attached to depolymerizing microtubules, which drive chromosome movements. How kinetochores associate with depolymerizing microtubules, which undergo dramatic structural changes forming curved protofilaments, has yet to b...

journal_title：Developmental cell

authors： Schmidt JC,Arthanari H,Boeszoermenyi A,Dashkevich NM,Wilson-Kubalek EM,Monnier N,Markus M,Oberer M,Milligan RA,Bathe M,Wagner G,Grishchuk EL,Cheeseman IM

更新日期：2012-11-13 00:00:00

abstract：:Previous studies have raised the possibility that Wnt signaling may regulate both neural progenitor maintenance and neuronal differentiation within a single population. Here we investigate the role of Wnt/β-catenin activity in the zebrafish hypothalamus and find that the pathway is first required for the proliferation...

journal_title：Developmental cell

authors： Wang X,Kopinke D,Lin J,McPherson AD,Duncan RN,Otsuna H,Moro E,Hoshijima K,Grunwald DJ,Argenton F,Chien CB,Murtaugh LC,Dorsky RI

更新日期：2012-09-11 00:00:00

abstract：:Although the mechanisms underlying the spatial pattern formation of sensory maps have been extensively investigated, those triggering sensory map formation during development are largely unknown. Here we show that the birth of pups instructively and selectively regulates the initiation of barrel formation in the somat...

journal_title：Developmental cell

authors： Toda T,Homma D,Tokuoka H,Hayakawa I,Sugimoto Y,Ichinose H,Kawasaki H

更新日期：2013-10-14 00:00:00

abstract：:Drosophila tracheal terminal branches are plastic and have the capacity to sprout out projections toward oxygen-starved areas, in a process analogous to mammalian angiogenesis. This response involves the upregulation of FGF/Branchless in hypoxic tissues, which binds its receptor Breathless on tracheal cells. Here, we ...

journal_title：Developmental cell

authors： Centanin L,Dekanty A,Romero N,Irisarri M,Gorr TA,Wappner P

更新日期：2008-04-01 00:00:00

abstract：:The intricate interplay between NF-kappaB and JNK determines TNF-alpha cytotoxicity. In a recent Cell paper, report that prolonged JNK1 activation promotes TNF-alpha killing via E3 ligase-mediated degradation of the caspase 8 inhibitor cFLIP(L). On the other hand, Ventura et al. (2006) show in their recent Molecular C...

journal_title：Developmental cell

authors： Lin A

更新日期：2006-03-01 00:00:00

abstract：:RITS (RNA-induced initiation of transcriptional gene silencing complex) plays diverse roles in heterochromatin regulation: silencing transcription by recruitment of chromatin modifiers and destroying transcripts by RNAi. In a recent issue of Molecular Cell, Li et al. now show that the polymerization of Tas3, a compone...

journal_title：Developmental cell

authors： Partridge JF

更新日期：2009-05-01 00:00:00

abstract：:Studies of myoblast fusion in Drosophila have revealed numerous signaling and structural proteins that regulate this critical event in muscle development. A paper by Chen et al. published in the September 19 issue of Cell adds ARF6, a GTPase, and one of its guanine nucleotide exchange factors to this set of players. ...

journal_title：Developmental cell

authors： Donaldson JG

更新日期：2003-10-01 00:00:00

abstract：:Serrate (SE) is a key component in RNA metabolism. Little is known about whether and how it can regulate epigenetic silencing. Here, we report histone methyltransferases ATXR5 and ATXR6 (ATXR5/6) as novel partners of SE. ATXR5/6 deposit histone 3 lysine 27 monomethylation (H3K27me1) to promote heterochromatin formatio...

journal_title：Developmental cell

authors： Ma Z,Castillo-González C,Wang Z,Sun D,Hu X,Shen X,Potok ME,Zhang X

更新日期：2018-06-18 00:00:00

abstract：:Centrosomes in mammalian cells have recently been implicated in cytokinesis; however, their role in this process is poorly defined. Here, we describe a human coiled-coil protein, Cep55 (centrosome protein 55 kDa), that localizes to the mother centriole during interphase. Despite its association with gamma-TuRC anchori...

journal_title：Developmental cell

authors： Fabbro M,Zhou BB,Takahashi M,Sarcevic B,Lal P,Graham ME,Gabrielli BG,Robinson PJ,Nigg EA,Ono Y,Khanna KK

更新日期：2005-10-01 00:00:00

abstract：:Theoretical modeling is central to elucidating underlying principles of emergent properties of complex systems. In cell and developmental biology, the last 15 years have witnessed a convergence of empirical and modeling approaches for fresh perspectives. The role of cell division in coordinating size, shape, and fate ...

journal_title：Developmental cell

authors： Bellaïche Y

更新日期：2016-09-26 00:00:00

abstract：:Regulated adhesion between cells and their environment is critical for normal cell migration. We have identified mutations in a gene encoding the Drosophila hydrogen peroxide (H₂O₂)-degrading enzyme Jafrac1, which lead to germ cell adhesion defects. During gastrulation, primordial germ cells (PGCs) associate tightly w...

journal_title：Developmental cell

authors： DeGennaro M,Hurd TR,Siekhaus DE,Biteau B,Jasper H,Lehmann R

更新日期：2011-02-15 00:00:00

abstract：:Loss of the kinase MAP3K4 causes mouse embryonic gonadal sex reversal due to reduced expression of the testis-determining gene, Sry. However, because of widespread expression of MAP3K4, the cellular basis of this misregulation was unclear. Here, we show that mice lacking Gadd45γ also exhibit XY gonadal sex reversal ca...

journal_title：Developmental cell

authors： Warr N,Carre GA,Siggers P,Faleato JV,Brixey R,Pope M,Bogani D,Childers M,Wells S,Scudamore CL,Tedesco M,del Barco Barrantes I,Nebreda AR,Trainor PA,Greenfield A

更新日期：2012-11-13 00:00:00

abstract：:The identities of the ubiquitin-ligases active during myogenesis are largely unknown. Here we describe a RING-type E3 ligase complex specified by the adaptor protein, Ozz, a novel SOCS protein that is developmentally regulated and expressed exclusively in striated muscle. In mice, the absence of Ozz results in overt m...

journal_title：Developmental cell

authors： Nastasi T,Bongiovanni A,Campos Y,Mann L,Toy JN,Bostrom J,Rottier R,Hahn C,Conaway JW,Harris AJ,D'Azzo A

更新日期：2004-02-01 00:00:00

abstract：:Transcriptional mediators of cell stress pathways, including HIF1α, ATF4, and p53, are key to normal development and play critical roles in disease, including ischemia and cancer. Despite their importance, mechanisms by which pathways mediated by these transcription factors interact with one another are not fully unde...

journal_title：Developmental cell

authors： Guimarães-Camboa N,Stowe J,Aneas I,Sakabe N,Cattaneo P,Henderson L,Kilberg MS,Johnson RS,Chen J,McCulloch AD,Nobrega MA,Evans SM,Zambon AC

更新日期：2015-06-08 00:00:00

abstract：:Recently, there has been a surge in the number of pioneering studies combining experiments with quantitative modeling to explain both relatively simple modules of molecular machinery of the cell and to achieve system-level understanding of cellular networks. Here we discuss the utility and methods of modeling and revi...

journal_title：Developmental cell

authors： Mogilner A,Wollman R,Marshall WF

更新日期：2006-09-01 00:00:00

abstract：:Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an attractive drug target in numerous maladies that range from heart disease to neurodegenerative disorders. The compound mdivi-1 is widely reported to inhibit Drp1-dependent fission, elongate mitochondria, and mitigate brain injury. Here...

journal_title：Developmental cell

authors： Bordt EA,Clerc P,Roelofs BA,Saladino AJ,Tretter L,Adam-Vizi V,Cherok E,Khalil A,Yadava N,Ge SX,Francis TC,Kennedy NW,Picton LK,Kumar T,Uppuluri S,Miller AM,Itoh K,Karbowski M,Sesaki H,Hill RB,Polster BM

更新日期：2017-03-27 00:00:00

abstract：:Odorant receptors (ORs) in the olfactory epithelium bind to volatile small molecules leading to the perception of smell. ORs are expressed in many tissues but their functions are largely unknown. We show multiple ORs display distinct mRNA expression patterns during myogenesis in vitro and muscle regeneration in vivo. ...

journal_title：Developmental cell

authors： Griffin CA,Kafadar KA,Pavlath GK

更新日期：2009-11-01 00:00:00

abstract：:Histone protein synthesis is activated as cells enter S phase to allow packaging of the newly replicated DNA into chromatin. In this issue of Developmental Cell, Takayama and coworkers elucidate a mechanism for silencing histone expression at the end of S phase in S. pombe. Failure to shut off histone expression disru...

journal_title：Developmental cell

authors： Marzluff WF

更新日期：2010-03-16 00:00:00

abstract：:Nakada et al. revisit the controversial question of whether membrane lipids are able to diffuse from the axon of a neuron into the soma. Using single molecule imaging of a fluorescent phospholipid, the authors show that a diffusion barrier in the axon initial segment blocks the diffusion of lipids. ...

journal_title：Developmental cell

authors： Boiko T,Winckler B

更新日期：2003-08-01 00:00:00

abstract：:The Par polarity complex creates mutually exclusive cortical domains in diverse animal cells. Activity of the atypical protein kinase C (aPKC) is a key output of the Par complex as phosphorylation removes substrates from the Par domain. Here, we investigate how diverse, apparently unrelated Par substrates couple phosp...

journal_title：Developmental cell

authors： Bailey MJ,Prehoda KE

更新日期：2015-10-26 00:00:00

abstract：:Border cells in the Drosophila ovary originate within an epithelium, detach from it, invade neighboring nurse cells, and migrate as a coherent cluster. This migration has served as a useful genetic model for understanding epithelial cell motility. The prevailing model of growth factor-mediated chemotaxis in general, a...

journal_title：Developmental cell

authors： Prasad M,Montell DJ

更新日期：2007-06-01 00:00:00

abstract：:RhoA stimulates cell contractility by recruiting downstream effectors to the cortical plasma membrane. We now show that direct binding by anillin is required for effective signaling: this antagonizes the otherwise labile membrane association of GTP-RhoA to promote effector recruitment. However, since its binding to Rh...

journal_title：Developmental cell

authors： Budnar S,Husain KB,Gomez GA,Naghibosadat M,Varma A,Verma S,Hamilton NA,Morris RG,Yap AS

更新日期：2019-06-17 00:00:00

abstract：:COPII vesicles assemble at ER subdomains called transitional ER (tER) sites, but the mechanism that generates tER sites is unknown. To study tER biogenesis, we analyzed the transmembrane protein Sec12, which initiates COPII vesicle formation. Sec12 is concentrated at discrete tER sites in the budding yeast Pichia past...

journal_title：Developmental cell

authors： Soderholm J,Bhattacharyya D,Strongin D,Markovitz V,Connerly PL,Reinke CA,Glick BS

更新日期：2004-05-01 00:00:00