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Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis.

Abstract：

:Recent data indicate that cystic fibrosis (CF) airway mucus is anaerobic. This suggests that Pseudomonas aeruginosa infection in CF reflects biofilm formation and persistence in an anaerobic environment. P. aeruginosa formed robust anaerobic biofilms, the viability of which requires rhl quorum sensing and nitric oxide (NO) reductase to modulate or prevent accumulation of toxic NO, a byproduct of anaerobic respiration. Proteomic analyses identified an outer membrane protein, OprF, that was upregulated approximately 40-fold under anaerobic versus aerobic conditions. Further, OprF exists in CF mucus, and CF patients raise antisera to OprF. An oprF mutant formed poor anaerobic biofilms, due, in part, to defects in anaerobic respiration. Thus, future investigations of CF pathogenesis and therapy should include a better understanding of anaerobic metabolism and biofilm development by P. aeruginosa.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Yoon SS,Hennigan RF,Hilliard GM,Ochsner UA,Parvatiyar K,Kamani MC,Allen HL,DeKievit TR,Gardner PR,Schwab U,Rowe JJ,Iglewski BH,McDermott TR,Mason RP,Wozniak DJ,Hancock RE,Parsek MR,Noah TL,Boucher RC,Hassett DJ

doi

10.1016/s1534-5807(02)00295-2

keywords:

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

593-603

issue

4

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(02)00295-2

journal_volume

3

pub_type

杂志文章

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