Reciprocal regulation between resting microglial dynamics and neuronal activity in vivo.

abstract：:piRNAs are known to silence transposable elements, but not all piRNAs match transposon sequences. Recent studies from Shen et al. (2018) and Zhang et al. (2018) identify rules for piRNA target recognition in Caenorhabditis elegans. Permissive pairing rules allow targeting of essentially all germline mRNAs, while prote...

journal_title：Developmental cell

authors： Svendsen JM,Montgomery TA

更新日期：2018-03-26 00:00:00

abstract：:Alzheimer's disease remains a formidable challenge for therapeutic management. In a recent report in Nature Structural and Molecular Biology, Cohen et al. (2015) present intriguing results showing that "designer" molecular chaperones may hold the key to an evolutionarily conserved program for management of toxic oligo...

journal_title：Developmental cell

authors： Singh JK,Balch WE

更新日期：2015-03-23 00:00:00

abstract：:Autophagy defects have recently been associated with chromosomal instability, a hallmark of human cancer. However, the functional specificity and mechanism of action of autophagy-related factors in genome stability remain elusive. Here we report that UVRAG, an autophagic tumor suppressor, plays a dual role in chromoso...

journal_title：Developmental cell

authors： Zhao Z,Oh S,Li D,Ni D,Pirooz SD,Lee JH,Yang S,Lee JY,Ghozalli I,Costanzo V,Stark JM,Liang C

更新日期：2012-05-15 00:00:00

abstract：:In this issue of Developmental Cell, Isabella and Horne-Badovinac (2016) show that Rab10 directs site-specific secretion of basement membrane components, which assemble into fibrils that spool out to elongate the Drosophila egg chamber. These findings establish the basement membrane's active role in tissue sculpting. ...

journal_title：Developmental cell

authors： Jayadev R,Sherwood DR

更新日期：2016-07-11 00:00:00

abstract：:The binding of Hedgehog (Hh) to its receptor Patched causes derepression of Smoothened (Smo), resulting in the activation of the Hh pathway. Here, we show that Smo activation is dependent on the levels of the phospholipid phosphatidylinositol-4 phosphate (PI4P). Loss of STT4 kinase, which is required for the generatio...

journal_title：Developmental cell

authors： Yavari A,Nagaraj R,Owusu-Ansah E,Folick A,Ngo K,Hillman T,Call G,Rohatgi R,Scott MP,Banerjee U

更新日期：2010-07-20 00:00:00

abstract：:The combination of fluid and mechanical properties exhibited by cell membranes enables a wealth of physical phenomena, many of which also have biological functions. A recent study in Cell (Shi et al., 2018) now shows that membrane tension in the cell may not be as simple as it first seemed. ...

journal_title：Developmental cell

authors： Groves JT

更新日期：2019-01-07 00:00:00

abstract：:In this issue of Developmental Cell, Jossin et al. (2017) show that the tumor suppressor protein Lgl1 interacts with N-cadherin to stabilize apical junctions in brain stem cells. Neural progenitors lacking Lgl1 had decreased N-cadherin internalization and abnormal cell junctions, generating an ectopic neuronal layer t...

journal_title：Developmental cell

authors： Sokol SY

更新日期：2017-06-05 00:00:00

abstract：:One G protein-coupled receptor (GPCR) can activate more than one G protein, but the physiologic importance of such activation has not been demonstrated in vivo. We have generated mice expressing exclusively a mutant form of the PTH/PTHrP receptor (DSEL) that activates adenylyl cyclase normally but not phospholipase C ...

journal_title：Developmental cell

authors： Guo J,Chung UI,Kondo H,Bringhurst FR,Kronenberg HM

更新日期：2002-08-01 00:00:00

abstract：:Pontin and reptin are conserved AAA+ ATPases identified in chromatin-remodeling complexes. In a recent issue of Cell, Venteicher et al. provide new insight into the function of pontin and reptin in telomerase biogenesis, which is important for cellular senescence, aging, and cancer. These unexpected findings have impl...

journal_title：Developmental cell

authors： Baek SH

更新日期：2008-04-01 00:00:00

abstract：:Recent data indicate that cystic fibrosis (CF) airway mucus is anaerobic. This suggests that Pseudomonas aeruginosa infection in CF reflects biofilm formation and persistence in an anaerobic environment. P. aeruginosa formed robust anaerobic biofilms, the viability of which requires rhl quorum sensing and nitric oxide...

journal_title：Developmental cell

authors： Yoon SS,Hennigan RF,Hilliard GM,Ochsner UA,Parvatiyar K,Kamani MC,Allen HL,DeKievit TR,Gardner PR,Schwab U,Rowe JJ,Iglewski BH,McDermott TR,Mason RP,Wozniak DJ,Hancock RE,Parsek MR,Noah TL,Boucher RC,Hassett DJ

更新日期：2002-10-01 00:00:00

abstract：:How kinetochores regulate microtubule dynamics to ensure proper kinetochore-microtubule interactions is unknown. Here, we studied this during early mitosis in Saccharomyces cerevisiae. When a microtubule shrinks and its plus end reaches a kinetochore bound to its lateral surface, the microtubule end attempts to tether...

journal_title：Developmental cell

authors： Gandhi SR,Gierliński M,Mino A,Tanaka K,Kitamura E,Clayton L,Tanaka TU

更新日期：2011-11-15 00:00:00

abstract：:The orientation of the mitotic spindle plays a key role in determining whether a polarized cell will divide symmetrically or asymmetrically. In most cell types, cytoplasmic dynein plays a critical role in spindle orientation. However, how dynein directs opposite spindle poles toward distinct and predetermined cell end...

journal_title：Developmental cell

authors： Grava S,Schaerer F,Faty M,Philippsen P,Barral Y

更新日期：2006-04-01 00:00:00

abstract：:Recent studies on aging in model systems such as yeast and roundworms have revealed conserved regulation of the process in response to nutrient availability and specific genes that appear to mediate this regulation. Here we review these findings with a focus on the nematode Caenorhabditis elegans and the budding yeast...

journal_title：Developmental cell

authors： Tissenbaum HA,Guarente L

更新日期：2002-01-01 00:00:00

abstract：:Transient receptor potential melastatin-like 7 (TRPM7) is a channel protein that also contains a regulatory serine-threonine kinase domain. Here, we find that Trpm7-/- T cells are deficient in Fas-receptor-induced apoptosis and that TRPM7 channel activity participates in the apoptotic process and is regulated by caspa...

journal_title：Developmental cell

authors： Desai BN,Krapivinsky G,Navarro B,Krapivinsky L,Carter BC,Febvay S,Delling M,Penumaka A,Ramsey IS,Manasian Y,Clapham DE

更新日期：2012-06-12 00:00:00

abstract：:In Drosophila, left/right (LR) asymmetry is apparent in the directional looping of the gut and male genitalia. The dextral orientation of the organs depends on the activity of a single gene, MyosinID (myoID), whose mutation leads to a fully inverted LR axis, thus revealing the activity of a recessive sinistral pathway...

journal_title：Developmental cell

authors： Coutelis JB,Géminard C,Spéder P,Suzanne M,Petzoldt AG,Noselli S

更新日期：2013-01-14 00:00:00

abstract：:Infectious, self-propagating protein aggregates (prions) as well as structurally related amyloid fibrils have traditionally been associated with neurodegenerative diseases in mammals. However, recent work in fungi indicates that prions are not simply aberrations of protein folding, but are in fact widespread, conserve...

journal_title：Developmental cell

authors： Osherovich LZ,Weissman JS

更新日期：2002-02-01 00:00:00

abstract：:Earlier, we reported that S6K1(-/-) mice have reduced body fat mass, have elevated rates of lipolysis, have severely decreased adipocyte size, and are resistant to high fat diet (HFD)-induced obesity. Here we report that adipocytes of S6K1(-/-) mice on a HFD have the capacity to increase in size to a degree comparable...

journal_title：Developmental cell

authors： Carnevalli LS,Masuda K,Frigerio F,Le Bacquer O,Um SH,Gandin V,Topisirovic I,Sonenberg N,Thomas G,Kozma SC

更新日期：2010-05-18 00:00:00

abstract：:The serine threonine kinase Akt is a core survival factor that underlies a variety of human diseases. Although regulatory phosphorylation and dephosphorylation have been well documented, the other posttranslational mechanisms that modulate Akt activity remain unclear. We show here that tetratricopeptide repeat domain ...

journal_title：Developmental cell

authors： Suizu F,Hiramuki Y,Okumura F,Matsuda M,Okumura AJ,Hirata N,Narita M,Kohno T,Yokota J,Bohgaki M,Obuse C,Hatakeyama S,Obata T,Noguchi M

更新日期：2009-12-01 00:00:00

abstract：:Metastasizing breast carcinoma cells have been hypothesized to mobilize tissue-invasive activity by co-opting the proteolytic systems employed by normal mammary epithelial cells undergoing branching morphogenesis. However, the critical effectors underlying morphogenesis remain unidentified, and their relationship to b...

journal_title：Developmental cell

authors： Feinberg TY,Zheng H,Liu R,Wicha MS,Yu SM,Weiss SJ

更新日期：2018-10-22 00:00:00

abstract：:In this issue of Developmental Cell, Yao et al. (2019) disrupt mitochondrial respiration in limb skeletal progenitors by conditionally deleting Tfam in the mouse embryo. They discover that not only is mitochondrial respiration dispensable for embryonic cartilage development, but also its elimination obviates the need ...

journal_title：Developmental cell

authors： Long F

更新日期：2019-06-03 00:00:00

abstract：:Recently reporting in Molecular Cell, Hussey et al. (2011) find that hnRNP E1 inhibits the translation of several genes essential for the epithelial-to-mesenchymal transition (EMT) by blocking eEF1A1 release during translation elongation. Phosphorylation of hnRNP E1 in response to TGF-β signaling disrupts the hnRNP E1...

journal_title：Developmental cell

authors： Zhang YE

更新日期：2011-03-15 00:00:00

abstract：:The Drosophila gene neuralized (neur) has long been recognized to be essential for the proper execution of a wide variety of processes mediated by the Notch (N) pathway, but its role in the pathway has been elusive. In this report, we present genetic and biochemical evidence that Neur is a RING-type, E3 ubiquitin liga...

journal_title：Developmental cell

authors： Lai EC,Deblandre GA,Kintner C,Rubin GM

更新日期：2001-12-01 00:00:00

abstract：:All pancreatic endocrine cells, producing glucagon, insulin, somatostatin, or PP, differentiate from Pdx1+ progenitors that transiently express Neurogenin3. To understand whether the competence of pancreatic progenitors changes over time, we generated transgenic mice expressing a tamoxifen-inducible Ngn3 fusion protei...

journal_title：Developmental cell

authors： Johansson KA,Dursun U,Jordan N,Gu G,Beermann F,Gradwohl G,Grapin-Botton A

更新日期：2007-03-01 00:00:00

abstract：:The sense organs of the vertebrate head comprise structures as varied as the eye, inner ear, and olfactory epithelium. In the early embryo, these assorted structures share a common developmental origin within the preplacodal region and acquire specific characteristics only later. Here we demonstrate a fundamental simi...

journal_title：Developmental cell

authors： Bailey AP,Bhattacharyya S,Bronner-Fraser M,Streit A

更新日期：2006-10-01 00:00:00

abstract：:How cells sense their physical microenvironment remains incompletely understood. In two recent Science articles, Lomakin et al. (2020) and Venturini et al. (2020) demonstrate that progressive nuclear deformation associated with cellular confinement triggers intracellular events that promote cell contractility and migr...

journal_title：Developmental cell

authors： Long JT,Lammerding J

更新日期：2021-01-25 00:00:00

abstract：:TORC1 regulates growth and metabolism, in part, by influencing transcriptional programs. Here, we identify REPTOR and REPTOR-BP as transcription factors downstream of TORC1 that are required for ∼ 90% of the transcriptional induction that occurs upon TORC1 inhibition in Drosophila. Thus, REPTOR and REPTOR-BP are major...

journal_title：Developmental cell

authors： Tiebe M,Lutz M,De La Garza A,Buechling T,Boutros M,Teleman AA

更新日期：2015-05-04 00:00:00

abstract：:Advances in molecular biology continue to help us uncover how information written into genes provides a blueprint for the initiation and orchestration of programs and processes that control cell division, cell-type specification, cell migration, cellular differentiation, and cell death. Clearly, molecular elements int...

journal_title：Developmental cell

authors： Pappu RV

更新日期：2020-10-12 00:00:00

abstract：:Membrane repair is essential for cell and organism survival. Exocytosis and endocytosis facilitate membrane repair in small wounds within a single cell; however, it remains unclear how large wounds in the plasma membrane are repaired in metazoans. Here, we show that wounding triggers rapid transcriptional upregulation...

journal_title：Developmental cell

authors： Meng X,Yang Q,Yu X,Zhou J,Ren X,Zhou Y,Xu S

更新日期：2020-09-14 00:00:00

abstract：:The appearance of Oskar protein occurs coincident with localization of oskar mRNA to the posterior pole of the Drosophila oocyte, and earlier accumulation of the protein is prevented by translational repression. We find that the nascent polypeptide-associated complex (NAC) is required for correct localization of oskar...

journal_title：Developmental cell

authors： Braat AK,Yan N,Arn E,Harrison D,Macdonald PM

更新日期：2004-07-01 00:00:00

abstract：:Reporting in Nature, Sanders et al. (2013) implicate filopodial projections in Sonic hedgehog (Shh) patterning of the limb. Actin-based filopodia transport Shh from producing cells, while filopodia of responding cells bear Cdon and Boc: coreceptors in the Shh pathway. These findings suggest a new mechanism of ligand m...

journal_title：Developmental cell

authors： McMahon AP,Hasso SM

更新日期：2013-05-28 00:00:00