Extracellular Vesicles: Satellites of Information Transfer in Cancer and Stem Cell Biology.

Abstract:

:The generation and shedding of extracellular vesicles (EVs), including exosomes and microvesicles (MVs), by cells has emerged as a form of intercellular communication with important roles in several physiological processes and diseases such as cancer. These membrane-enclosed packets can transfer specific proteins, RNA transcripts, microRNAs, and even DNA to target cells, thereby altering their function. Despite the exponential growth of the EV field, a great deal remains unclear about the mechanisms that regulate exosome and MV biogenesis, as well as about how to isolate different classes of EVs and how to best take advantage of them for clinical applications.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Desrochers LM,Antonyak MA,Cerione RA

doi

10.1016/j.devcel.2016.04.019

subject

Has Abstract

pub_date

2016-05-23 00:00:00

pages

301-309

issue

4

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(16)30239-8

journal_volume

37

pub_type

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