Interaction of Bordetella adenylate cyclase toxin with complement receptor 3 involves multivalent glycan binding.

abstract：:One of the most intriguing plant defense reactions against herbivores is the emission of volatiles as potentially attractive signals for the natural enemies of the attacking species. Like many other low and high molecular weight chemical defenses, volatile production is under the control of the octadecanoid signalling...

journal_title：FEBS letters

authors： Krumm T,Bandemer K,Boland W

更新日期：1995-12-27 00:00:00

abstract：:The human pathogen Vibrio vulnificus undergoes phase variation among colonial morphotypes, including a virulent opaque form which produces capsular polysaccharide (CPS) and a translucent phenotype that produces little or no CPS and is attenuated. Here, we found that a V. vulnificus mutant defective for RfaH antitermin...

journal_title：FEBS letters

authors： Garrett SB,Garrison-Schilling KL,Cooke JT,Pettis GS

更新日期：2016-12-01 00:00:00

abstract：:Phlorizin, a potent inhibitor of the Na+/D-glucose cotransporter, was derivatised to 3-aminophlorizin and subsequently coupled to Affi-Gel 15. Affinity chromatography of pig kidney brush border membranes solubilised in Triton X-100 allowed the purification of a 60 kDa protein on this resin. We consider this protein to...

journal_title：FEBS letters

authors： Kitlar T,Morrison AI,Kinne R,Deutscher J

更新日期：1988-07-04 00:00:00

abstract：:The human ether-a-go-go-related gene (herg) encodes a K+ current (I(HERG)) which plays a fundamental role in heart excitability and in neurons by contributing to action potential repolarization and to spike-frequency adaptation, respectively. In this paper we show that I(HERG), recorded in neuroblastoma cells and guin...

journal_title：FEBS letters

authors： Rosati B,Rocchetti M,Zaza A,Wanke E

更新日期：1998-11-27 00:00:00

abstract：:The present study investigated the mechanism by which eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) inhibit platelet activation induced by thromboxane A2. DHA was found to be more potent than EPA in blocking platelet aggregation induced by the stable thromboxane A2 mimetic, U46619. Furthermore, this inhib...

journal_title：FEBS letters

authors： Swann PG,Venton DL,Le Breton GC

更新日期：1989-01-30 00:00:00

abstract：:Tau exon 10 (E10) splicing is a crucial event in its developmental change of tau isoform and tauopathy. To investigate the splicing mechanism, we isolated and compared mouse tau genomic sequence with human sequence. We identified a new element in mouse intron 10 (I10) to suppress E10 splicing, which was located just a...

journal_title：FEBS letters

authors： Yamashita T,Tomiyama T,Li Q,Numata H,Mori H

更新日期：2005-01-03 00:00:00

abstract：:The effect of the inositol phospholipid-binding antibiotic neomycin was studied on high-affinity GTPase in human platelet membranes. At low concentrations (up to 1 mM), neomycin by itself stimulated a high-affinity GTPase. This GTPase stimulation was additive with that caused by the hormonal factors, prostaglandin E1 ...

journal_title：FEBS letters

authors： Herrmann E,Jakobs KH

更新日期：1988-02-29 00:00:00

abstract：:Addition of hydrocortisone to the rat mammary gland myoepithelial cell line, G4.2.3, induces the synthesis and secretion of alpha 2-macroglobulin. Interleukin-1 beta, interleukin-6 and transforming growth factor-beta synergize with hydrocortisone, increasing the synthesis of alpha 2-macroglobulin 2- to 4-fold, althoug...

journal_title：FEBS letters

authors： Warburton MJ,Gusterson BA,O'Hare MJ

更新日期：1993-10-11 00:00:00

abstract：:Oogenesis of amphibians is an atypical situation in which histone mRNA is polyadenylated. The poly(A) tract on H4 mRNA has been examined by S1 nuclease analysis. Throughout oogenesis the poly(A) tract is very short, and nonexistent on some mRNA molecules. The poly(A) tract is completely removed during maturation of th...

journal_title：FEBS letters

authors： Ballantine JE,Woodland HR

更新日期：1985-01-28 00:00:00

abstract：:The complete primary structure (967 amino acids) of an intestinal human aminopeptidase N (EC 3.4.11.2) was deduced from the sequence of a cDNA clone. Aminopeptidase N is anchored to the microvillar membrane via an uncleaved signal for membrane insertion. A domain constituting amino acid 250-555 positioned within the c...

journal_title：FEBS letters

authors： Olsen J,Cowell GM,Kønigshøfer E,Danielsen EM,Møller J,Laustsen L,Hansen OC,Welinder KG,Engberg J,Hunziker W

更新日期：1988-10-10 00:00:00

abstract：:Understanding protein beta structures has been hindered by the challenge of designing small, well-folded β-sheet systems. A β-capping motif was previously designed to help solve this problem, but not without limitations, as the termini of this β-cap were not fully available for chain extension. Combining Coulombic sid...

journal_title：FEBS letters

authors： Anderson JM,Kier BL,Shcherbakov AA,Andersen NH

更新日期：2014-12-20 00:00:00

abstract：:Thrombin is a multifunctional enzyme involved in coagulation, cell modulation and inflammation. We recently reported a novel membrane-associated prothrombin activator, abbreviated as MAPA, found in cultured fibroblasts and glial cell lines. In this study, we examined the physiological role of this enzyme. MAPA-like ac...

journal_title：FEBS letters

authors： Shikamoto Y,Shibusawa S,Okuyama I,Morita T

更新日期：1997-08-04 00:00:00

abstract：:The internalisation of metabotropic glutamate receptor (mGluR1alpha) and its splice variant (mGluR1beta), in response to agonist and phorbol esters (PMA), has been studied. Both mGluR1alpha and mGluR1beta exhibit a similar rate of internalisation following PMA treatment, with a shift in their distribution from plasma ...

journal_title：FEBS letters

authors： Ciruela F,McIlhinney RA

更新日期：1997-11-24 00:00:00

abstract：:Cell-substratum adhesion of rat hepatocytes was inhibited by antisera raised against plasma membranes of liver (anti-liver antiserum) and Morris hepatoma 7777 (anti-hepatoma antiserum). Similar concentrations of both antisera inhibited adhesion on collagen. Anti-liver antiserum also inhibited the adhesion of hepatocyt...

journal_title：FEBS letters

authors： Neumeier R,Dethlefs U,Reutter W

更新日期：1984-03-26 00:00:00

abstract：:Members of the Trp protein family have been suggested as the structural basis of store-operated cation conductances. With this study, we provide evidence for the expression of three isoforms of Trp (hTrp1, 3 and 4) in human umbilical vein endothelial cells (HUVEC). The role of Trp proteins in store regulation of endot...

journal_title：FEBS letters

authors： Groschner K,Hingel S,Lintschinger B,Balzer M,Romanin C,Zhu X,Schreibmayer W

更新日期：1998-10-16 00:00:00

abstract：:The roles of mild uncoupling caused by free fatty acids (mediated by plant uncoupling mitochondrial protein (PUMP) and ATP/ADP carrier (AAC)) and non-coupled respiration (alternative oxidase (AO)) on H(2)O(2) formation by plant mitochondria were examined. Both laurate and oleate prevent H(2)O(2) formation dependent on...

journal_title：FEBS letters

authors： Casolo V,Braidot E,Chiandussi E,Macrì F,Vianello A

更新日期：2000-05-26 00:00:00

abstract：:NELL1 is an extracellular protein inducing osteogenic differentiation and bone formation of osteoblastic cells. To elucidate the intracellular signaling cascade evoked by NELL1, we have shown that NELL1 protein transiently activates the MAPK signaling cascade, induces the phosphorylation of Runx2, and promotes the rap...

journal_title：FEBS letters

authors： Bokui N,Otani T,Igarashi K,Kaku J,Oda M,Nagaoka T,Seno M,Tatematsu K,Okajima T,Matsuzaki T,Ting K,Tanizawa K,Kuroda S

更新日期：2008-01-23 00:00:00

abstract：:The full-length cDNA encoding the human calbindin-D9k (CaBP-9k) has been cloned using reverse transcription/PCR methodology with rat- and bovine-derived primers and intestinal RNA. A core product, and both a 5' and 3' product encompassing the full-length cDNA were obtained. The clones include coding region for 79 amin...

journal_title：FEBS letters

authors： Jeung EB,Krisinger J,Dann JL,Leung PC

更新日期：1992-07-28 00:00:00

abstract：:A cell-free protein expression system was established that provides protein samples of adequate concentration and purity for direct NMR analysis. The Escherichia coli peptidyl-prolyl cis-trans isomerase PpiB was expressed in this system with dual amino acid-selective isotope labeling to identify the NMR signal from th...

journal_title：FEBS letters

authors： Guignard L,Ozawa K,Pursglove SE,Otting G,Dixon NE

更新日期：2002-07-31 00:00:00

abstract：:The assembly of cytochrome c oxidase subunits I-III was studied in vitro in isolated rat liver mitochondria pre-labeled with [35S]methionine. Individual subunits were immunoabsorbed with monospecific antibodies. Isolated heme a from rat liver mitochondria, when added to radiolabeled mitochondria, induced assembly of s...

journal_title：FEBS letters

authors： Wielburski A,Nelson BD

更新日期：1984-11-19 00:00:00

abstract：:A microsomal fraction prepared from the mycelia of the band (bd) strain of Neurospora crassa showed enhanced phosphorylation of two small proteins with molecular masses of around 15 kDa (ps15) by the irradiation of the reaction mixture containing [gamma-32P]ATP at 0 degrees C for 1 s with blue light (450 nm, 6 mumol/m...

journal_title：FEBS letters

authors： Oda K,Hasunuma K

更新日期：1994-05-30 00:00:00

abstract：:The photophobic receptor (psRII) and its transducer pHtrII from Natronobacterium pharaonis were heterologously coexpressed in the phototaxis-deficient Halobacterium salinarium strain Pho81/w which lacks all four bacterial rhodopsins, i.e. the two ion pumps bacteriorhodopsin and halorhodopsin as well as the two sensory...

journal_title：FEBS letters

authors： Lüttenberg B,Wolff EK,Engelhard M

更新日期：1998-04-10 00:00:00

abstract：:Using rheumatoid arthritis (RA) and periodontitis mouse models, we demonstrate that RA and periodontitis share many pathological features, such as deregulated cytokine production, increased immune-cell infiltration, increased expression of Toll-like receptors (TLRs), and enhanced osteoclast activity and bone erosion. ...

journal_title：FEBS letters

authors： Hao L,Zhu G,Lu Y,Wang M,Jules J,Zhou X,Chen W

更新日期：2015-05-22 00:00:00

abstract：:Rat brain S-100 (S-100b) and ox brain S-100a0, S-100a and S-100b have been tested for their ability to control the assembly and disassembly of brain microtubule proteins in the presence of either Ca2+ or Zn2+, in vitro. In the presence of Ca2+, single S-100 isoforms have similar, if not identical, effects, i.e. they i...

journal_title：FEBS letters

authors： Donato R,Isobe T,Okuyama T

更新日期：1985-07-01 00:00:00

abstract：:Regulatory protein kinases are involved in various cellular processes such as proliferation, differentiation, and apoptosis. Using cDNA differential display, we identified MOK, a member of the mitogen-activated protein kinase superfamily, as one of the genes induced by a caudal-related homeobox transcription factor, C...

journal_title：FEBS letters

authors： Uesaka T,Kageyama N

更新日期：2004-08-27 00:00:00

abstract：:By co-expression of heme oxygenase and various bilin reductase(s) in a single operon in conjunction with apophytochrome using two compatible plasmids, we developed a system to produce phytochromes with various chromophores in Escherichia coli. Through the selection of different bilin reductases, apophytochromes were a...

journal_title：FEBS letters

authors： Mukougawa K,Kanamoto H,Kobayashi T,Yokota A,Kohchi T

更新日期：2006-02-20 00:00:00

abstract：:We recently showed that some of the enzymes underpinning cellulose solubilization by Ruminococcus albus 8 lack the conventional type of dockerin module characteristic of cellulosomal proteins and instead, bear an "X" domain of unknown function at their C-termini. We have now subcloned and expressed six X domains and s...

journal_title：FEBS letters

authors： Xu Q,Morrison M,Nelson KE,Bayer EA,Atamna N,Lamed R

更新日期：2004-05-21 00:00:00

abstract：:The primary structure of nuclear factor-I (CTF/NF-I), a eukaryotic regulatory DNA-binding protein involved in both DNA replication and gene transcription, and the secondary structure predictable from it, are compared here with those of a number of prokaryotic acetylases. Hydropathy and Chou-Fasman analyses reveal that...

journal_title：FEBS letters

authors： Oikarinen J,Mannermaa RM

更新日期：1990-10-29 00:00:00

abstract：:SufC is an ATPase component of the SUF machinery, which is involved in the biosynthesis of Fe-S clusters. To gain insight into the function of this protein, we have determined the crystal structure of Escherichia coli SufC at 2.5A resolution. Despite the similarity of the overall structure with ABC-ATPases (nucleotide...

journal_title：FEBS letters

authors： Kitaoka S,Wada K,Hasegawa Y,Minami Y,Fukuyama K,Takahashi Y

更新日期：2006-01-09 00:00:00

abstract：:We report here the synthesis of novel 5'-linked oligodeoxynucleotides, both normal phosphodiester and phosphorothioate analogs, in which a covalently attached group at the 5'-terminus is an anthraquinone. These compounds represent a new class of antisense compounds in which the base sequence of the oligodeoxynucleotid...

journal_title：FEBS letters

authors： Mori K,Subasinghe C,Cohen JS

更新日期：1989-06-05 00:00:00