Abstract:
:Life history theory proposes that menopause is either an epiphenomenon or an adaptation. The most recent adaptive hypothesis proposes that menopause in humans has evolved because of conflict between reproducing generations (RCH). Overlapping reproduction between generations may impose fitness costs to older and younger females who co-breed. However, it has yet to be demonstrated by using a measure of evolutionary fitness (i.e. grandchildren). Here, we tested the RCH by using multigenerational life-history data of historical Norwegian women. Our results indicate that both generations seem to experience some fitness benefits with co-breeding (i.e. reproductive overlap and cohabit). This was because both younger and older females who co-bred had more grandchildren than those who did not co-breed. We suggest that younger females may partly had enhanced fitness because they copied behaviour of females of the older generation. Our results do not support the hypothesis that reproductive conflict between generations explains the evolution of menopause in women. Our results, taken together with the growing evidence against several assumptions of the RCH, indicate that 1) the decline in follicle number has no marked increase in women as they reach the age of 38 years; 2) humans do not have an abrupt decline in fertility at mean age of 38 years; 3) menopause is not unique to humans; and 4) there are not high numbers of individuals surviving to older adulthood during our evolutionary past. Finally, we discuss an alternative point of view suggesting that menopause might be understood in the light of both ageing in general as well as our increased lifespan.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Skjærvø GR,Røskaft Edoi
10.1016/j.exger.2013.02.001subject
Has Abstractpub_date
2013-04-01 00:00:00pages
408-13issue
4eissn
0531-5565issn
1873-6815pii
S0531-5565(13)00032-6journal_volume
48pub_type
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Experimental gerontology
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doi:10.1016/j.exger.2004.08.007
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(83)90018-9
更新日期:1983-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/0531-5565(92)90012-o
更新日期:1992-09-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2006.01.011
更新日期:2006-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.exger.2019.110754
更新日期:2019-12-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.exger.2018.06.007
更新日期:2018-09-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(01)00145-0
更新日期:2001-11-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2006.11.015
更新日期:2007-05-01 00:00:00
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doi:10.1016/j.exger.2018.11.005
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2006.06.055
更新日期:2006-09-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2006.04.006
更新日期:2006-08-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(90)90032-w
更新日期:1990-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.01.013
更新日期:2014-04-01 00:00:00
abstract::Age-related changes of gene expression contribute to the physiological alteration observed with human ageing. Herein, the abundance of a selection of 148 transcripts involved in immunosenescence and stress response was compared in total RNA of PBMC of healthy young to middle-age probands (35.0 +/- 6.5 year old) and he...
journal_title:Experimental gerontology
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doi:10.1016/j.exger.2009.12.001
更新日期:2010-03-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2009.03.003
更新日期:2009-06-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2003.12.006
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