Abstract:
:Aromatase inhibitors have become the standard of care for the adjuvant treatment of postmenopausal, hormone-sensitive breast cancer. Meanwhile, more and more breast cancer patients who are treated with aromatase inhibitors as adjuvant therapies often experience arthralgias and musculoskeletal aching, in some cases, have necessitated discontinuation of treatment. We therefore use a rat model of human RA to test the hypothesis that anastrozole, an aromatase inhibitor, could enhance arthritis. The parameters used for analyzing the disease severity included paw volume, radiology, histopathological examination, markers for cytokine profile, immunophenotypic assays, and immune response to type II collagen. Administration of anastrozole significantly increased the severity of arthritis. Anastrozole induced the increased levels of proinflammatory cytokines, IFN-gamma, IL-12, and the decreased levels of IL-4, IL-10 secretion. We further found that anastrozole suppressed the differentiation of naive T cells to Treg cells, and it blocked the balance of IgG2a/IgG1 in peripheral blood. Meanwhile, estradiol concentration was the lowest in the anastrozole group. In a well-established model of postmenopausal RA, anastrozole potently promote the progression of arthritis and the associated development of osteoporosis. This potential problem should alert the oncologists and other health professionals.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Wang J,Zhang Q,Jin S,Feng M,Kang X,Zhao S,Liu S,Zhao Wdoi
10.1016/j.exger.2009.03.003subject
Has Abstractpub_date
2009-06-01 00:00:00pages
398-405issue
6-7eissn
0531-5565issn
1873-6815pii
S0531-5565(09)00039-4journal_volume
44pub_type
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2008.09.010
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journal_title:Experimental gerontology
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pub_type: 杂志文章,评审
doi:10.1016/j.exger.2017.12.022
更新日期:2018-05-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.01.022
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(89)90030-2
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doi:10.1016/s0531-5565(01)00145-0
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2005.10.006
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
pub_type: 杂志文章
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