Abstract：
:DNA binding of the ku protein was investigated in peripheral blood mononuclear cells (PBMC) from 24 subjects of different ages (20-89 years old) displaying age-related changes in DNA repair, mitotic responsiveness, and cytokine production. Ku is an heterodimeric protein composed of two subunits of 70 and 80 kDa, which is involved in the earliest steps of DNA damage recognition. DNA binding of ku 70/80 was found unchanged in normal PBMC from aging subjects but progressively declined in x-ray-irradiated PBMC from young to adult, and elderly subjects. This finding was concomitant with the age-related fall of DNA repair in the whole population.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Frasca D,Barattini P,Tirindelli D,Guidi L,Bartoloni C,Errani A,Costanzo M,Tricerri A,Pierelli L,Doria Gdoi
10.1016/s0531-5565(99)00026-1keywords:
subject
Has Abstractpub_date
1999-08-01 00:00:00pages
645-58issue
5eissn
0531-5565issn
1873-6815pii
S0531-5565(99)00026-1journal_volume
34pub_type
杂志文章abstract：:During aging declining maximum force capacity with more or less unchanged fatigability is observed with the underlying mechanisms still not fully understood. Therefore, we compared morphology and function of skeletal muscles between different age groups. Changes in high-energy phosphate turnover (PCr, Pi and pH) and m...
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journal_title：Experimental gerontology
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abstract：:The purpose of this study was to examine the combined cardiorespiratory and cerebrovascular responses to head-up tilt (HUT) in young and older trained and untrained humans following moderate-duration exercise. Middle cerebral artery blood flow velocity (MCAv; transcranial Doppler ultrasound), blood pressure (BP; Finom...
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/0531-5565(94)00066-c
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abstract：:Osteoporosis is extremely frequent in post-menopausal women; nevertheless, osteoporosis in men is also a severe and frequently occurring but often underestimated disease. Increasing evidence links bone loss in male idiopathic osteoporosis and age related osteoporosis to osteoblast dysfunction rather than increased ost...
journal_title：Experimental gerontology
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pub_type： 杂志文章
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abstract：:We have developed a simian virus 40 (SV40) T-antigen immortalized human cell line, 1MR90-D305.2H4 (IDH4), in which the expression of T-antigen is controlled by the mouse mammary tumor virus (MMTV) promoter and thus regulated by steroids such as dexamethasone. Studies on the regulation of proliferation by T-antigen led...
journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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更新日期：1982-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：2008-08-01 00:00:00
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.05.008
更新日期：2016-08-01 00:00:00
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.10.005
更新日期：2010-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2009.10.010
更新日期：2010-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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更新日期：2006-02-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：2009-10-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：2003-04-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,随机对照试验
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更新日期：2018-07-15 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2008.11.005
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.02.003
更新日期：2013-10-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.exger.2016.03.008
更新日期：2016-06-15 00:00:00
abstract：:Motor performance of rats of different ages was determined in a cross sectional study. The design includes a test battery of seven motor tasks of graduated complexity. The results show a hierarchical order of impairments of motor functions in aging rats; that is, the more complex the task requirement, the earlier and ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(83)90018-9
更新日期：1983-01-01 00:00:00
