Abstract：
:Calorie restriction (CR) and a reduced growth hormone (GH) signal affect insulin sensitivity and lifespan in mammals in a similar manner. We investigated the effects of CR and moderate inhibition of GH on glucose-stimulated activation of insulin signaling and the expression of genes related to fat metabolism in white adipose tissue (WAT) in rats. We used 10-month-old male, wild-type (W) Wistar rats, fed ad libitum (AL) or a 30% CR diet from 6weeks of age, and transgenic (Tg) rats with moderately suppressed GH signaling. Rats were killed 15min after an intraperitoneal injection of glucose or saline. In control W-AL rats, the levels of serum insulin, phosphorylated (p) insulin receptor (pY-IR), p-Akt, and the expression of glucose transporter (Glut) 4 in the membrane fraction were greater in the glucose-injected group than in the saline-injected group, indicating significant activation of insulin signaling in response to glucose loading. In the W-CR and Tg-AL rats, the serum insulin and pY-IR levels were lower than those in the W-AL rats. The Akt-Glut pathway was up-regulated even after saline-injection. Expression levels of adipogenic and lipogenic genes including PPARgamma, adiponectin, and its receptors, were higher in the W-CR rats than in the W-AL and Tg-AL rats. The present findings indicate adipose tissue metabolic profiles specific to CR.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Park S,Komatsu T,Hayashi H,Trindade LS,Yamaza H,Chiba T,Shimokawa Idoi
10.1016/j.exger.2009.07.002subject
Has Abstractpub_date
2009-10-01 00:00:00pages
646-52issue
10eissn
0531-5565issn
1873-6815pii
S0531-5565(09)00139-9journal_volume
44pub_type
杂志文章abstract：:Histological surveys of the hearts of guppies Poecilia reticulatus throughout their lifespan showed no aging changes until the fish were three years old. In younger fishes the hearts were healthy, even in three individuals with "wasting" disease, where there was considerable loss of muscle throughout the body. There w...
journal_title：Experimental gerontology
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doi：10.1016/0531-5565(84)90048-2
更新日期：1984-01-01 00:00:00
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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doi：10.1016/j.exger.2017.09.019
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(00)00210-2
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abstract：:Skeletal muscle atrophy reduces quality of life and increases morbidity and mortality in patients with chronic conditions. Oxidative stress is a key factor contributing to skeletal muscle atrophy by altering both protein synthesis and protein degradation pathways. Beta-lapachone (Beta-L) is known to act as a pro-oxida...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.110711
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abstract：:Ageing is defined as the loss of ability to maintain cellular homeostasis of an organism associated with the free radical-elicited oxidative damage to cellular macromolecules. The aim of this study was to evaluate the efficacy of epigallocatechin-3-gallate (EGCG), the key component of green tea catechins on attenuatin...
journal_title：Experimental gerontology
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doi：10.1016/j.exger.2007.10.017
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journal_title：Experimental gerontology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.exger.2015.07.006
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(82)90025-0
更新日期：1982-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2006.06.004
更新日期：2007-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2012.06.015
更新日期：2012-12-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111222
更新日期：2020-12-29 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.09.019
更新日期：2014-12-01 00:00:00
abstract：:During the course of life, cyclic females face a state of midlife transition that occurs in a fully functioning neurological system, and results in reproductive senescence. The authors' hypothesis was that changes in the activity noradrenergic neurons may be one of the factors involved in this phenomenon. The aim of t...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.04.015
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Low muscle strength (dynapenia) is a primary characteristic of sarcopenia, the age-related loss of muscle mass and strength or low walking speed. New evidence suggests that muscle strength positively affects blood pressure (BP) responses to exercise. As older adults with lowest handgrip strength also have lo...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.110984
更新日期：2020-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(97)00113-7
更新日期：1998-05-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2019.110817
更新日期：2020-03-01 00:00:00
abstract：INTRODUCTION:The ageing process can be influenced by different dietary patterns and dietary factors. AIM:To analyse the association of dietary factors, which include the Mediterranean diet adherence, the compliance with the "Sociedad Española de Nutrición Comunitaria" food portion recommendations, and the intake of di...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.01.019
更新日期：2019-05-01 00:00:00
abstract：:Inducible nitric oxide synthase (iNOS) is involved in obesity-induced insulin resistance. Since aging is accompanied by increased iNOS expression, the effect of iNOS gene deletion on aging-associated insulin resistance was investigated in 7-month-old (adult) and 22-month-old (old) iNOS knockout and wild-type mice usin...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2010.05.004
更新日期：2010-09-01 00:00:00
abstract：:A non-enzymatic reaction between ketones or aldehydes and the amino groups of proteins, lipids and nucleic acids contributes to the aging of macromolecules and to the development and progression of various age-related disorders such as vascular complications of diabetes, Alzheimer's disease, cancer growth and metastas...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2010.11.007
更新日期：2011-04-01 00:00:00
abstract：:To study the several elements and causes of ageing, diverse model organisms and methodologies are required. The most frequently used models are Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster and rodents. All have their advantages and disadvantages and allow studying particular aspects of the...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2008.11.007
更新日期：2009-04-01 00:00:00
abstract：:The Senescence-Accelerated Mouse (SAM) strains are unique and appropriate models for genetic studies on aging because the SAMP strains have an "accelerated senescence" phenotype for which the SAMR strains are controls, and each SAMP strain has a strain-specific age-associated disorder. Furthermore, because they have g...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(96)00060-5
更新日期：1997-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.07.007
更新日期：2013-11-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.exger.2015.08.013
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVES:1) To determine if there was a practice effect associated with walk tests performed by frail older adults with and without dementia, 2) to examine the role of systematic cueing in the walk tests for those with dementia, and 3) to make recommendations to testing protocols of the walk tests for frail older adu...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.110648
更新日期：2019-09-01 00:00:00
abstract：:There is an age-associated reduction in the bone healing activity of bone morphogenetic protein-2 (BMP-2) that is currently addressed by administering higher doses of BMP-2 in elderly patients. The unwanted medical complications from high dose BMP-2 motivated this investigation to determine whether the addition of a l...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.02.006
更新日期：2015-04-01 00:00:00
abstract：:Skeletal remodelling is a continuous process during life and is still active also in extreme senescence. In the elderly, bone resorption often prevails over bone formation, causing bone loss and fragility. Elderly subjects are exposed to the risk of fractures, and loss of self-sufficiency, if considering that the prox...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2007.06.013
更新日期：2008-02-01 00:00:00
abstract：:We tested the hypothesis that hesperidin would reverse age-related aortic stiffness, perivascular adipose (PVAT) mediated-arterial stiffening and PVAT advanced glycation end-products (AGE) accumulation. Aortic pulse wave velocity (aPWV) and intrinsic mechanical stiffness, two measures of arterial stiffness, were asses...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.08.003
更新日期：2017-10-15 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.10.002
更新日期：2016-12-01 00:00:00
abstract：:A correct clinical diagnosis in the early stage of Alzheimer Disease (AD) is mandatory given the current available treatment with acetylcholine esterase inhibitors. Moreover, a early to preclinical diagnosis would allow to identify patients eligible for future disease-modifying therapies. In the last ten years, we hav...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2009.08.004
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Homocysteine (Hcy) high levels are associated with fractures, bone resorption and an early onset of osteoporosis in elderly persons; a relationship between Hcy and bone formation has also been suggested but is still controversial. Frailty, an independent predictor of fractures and decreased bone mineral dens...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2018.04.019
更新日期：2018-07-15 00:00:00
