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Extension of Drosophila lifespan by cinnamon through a sex-specific dependence on the insulin receptor substrate chico.

Abstract：

:Cinnamon is a spice commonly used worldwide to flavor desserts, fruits, cereals, breads, and meats. Numerous health benefits have been attributed to its consumption, including the recent suggestion that it may decrease blood glucose levels in people with diabetes. Insulin signaling is an integral pathway regulating the lifespan of laboratory organisms, such as worms, flies, and mice. We posited that if cinnamon truly improved the clinical signs of diabetes in people that it would also act on insulin signaling in laboratory organisms and increase lifespan. We found that cinnamon did extend lifespan in the fruit fly, Drosophila melanogaster. However, it had no effect on the expression levels of the 3 aging-related Drosophila insulin-like peptides nor did it alter sugar, fat, or soluble protein levels, as would be predicted. In addition, cinnamon exhibited no protective effects in males against oxidative challenges. However, in females it did confer a protective effect against paraquat, but sensitized them to iron. Cinnamon provided no protective effect against desiccation and starvation in females, but sensitized males to both. Interestingly, cinnamon protected both sexes against cold, sensitized both to heat, and elevated HSP70 expression levels. We also found that cinnamon required the insulin receptor substrate to extend lifespan in males, but not females. We conclude that cinnamon does not extend lifespan by improving stress tolerance in general, though it does act, at least in part, through insulin signaling.

journal_name

Exp Gerontol

journal_title

Experimental gerontology

authors

Schriner SE,Kuramada S,Lopez TE,Truong S,Pham A,Jafari M

doi

10.1016/j.exger.2014.09.019

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

220-30

eissn

0531-5565

issn

1873-6815

pii

S0531-5565(14)00282-4

journal_volume

60

pub_type

杂志文章

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