Abstract:
:We have analyzed birth records from the International Species Inventory System database of zoo animals to describe patterns of fertility as a function of age in birds and mammals. Unlike age at death, fertility in captive populations is partly controlled by animal keepers depending on availability of space and potential mates and on the aims of captive propagation programs. Thus, fertility records must be considered carefully to avoid potential age-specific biases. The zoo data suggest that fertility declines from a peak at young adult ages in most species. The rate of decline in reproductive function is correlated with the rate of somatic aging, indicated by the increase in mortality rate with age, and with the age at peak fertility. Over the sample as a whole, these patterns do not differ systematically between the sexes, nor do they differ between birds and mammals. While it is clear that the demographic consequences of aging of the reproductive system follow a different course than the aging of somatic tissue, the rates of each are correlated either through functional connections or through parallel evolutionary responses to common selective factors.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Ricklefs RE,Scheuerlein A,Cohen Adoi
10.1016/s0531-5565(03)00101-3keywords:
subject
Has Abstractpub_date
2003-07-01 00:00:00pages
741-5issue
7eissn
0531-5565issn
1873-6815pii
S0531556503001013journal_volume
38pub_type
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journal_title:Experimental gerontology
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abstract::A series of theoretical analyses of mortality were performed on recent data for Mediterranean fruit flies (Ceratitus capitata). Best fit computations were performed using the Marquardt-Levenburg technique on: 1) the classic Gompertz model, 2) the Johnson-Mehl-Avrami (JMA) model from chemical kinetics theory, which is ...
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abstract::The aim of this study was to compare voluntary and involuntary force generating capacity of the triceps surae muscles in healthy young and older adult participants during isometric and isokinetic contractions. Ultrasound was used to measure medial gastrocnemius (MG) fascicle length during maximal voluntary isometric c...
journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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更新日期:2002-08-01 00:00:00
abstract:THE AIM:The aim of this study was to determine whether polymorphisms of the VDR gene may increase the risk of Alzheimer disease (AD) development in Lower Silesian patients in comparison with other populations. MATERIAL AND METHODS:108 AD patients (aged 73.7±8.6) vs 77 healthy volunteers (aged 64.5±7.8) in the Lower Si...
journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
abstract::The age-associated decline in the regenerative abilities of mesenchymal stem cells (MSCs) may be due to age-related changes in reduction in number, intrinsic properties of MSCs and extrinsic factors of the extracellular environment (the stem cell niche). The effect of age on the efficacy of MSC transplantation on rege...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.01.020
更新日期:2014-04-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2005.07.006
更新日期:2005-12-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
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更新日期:1989-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(98)00008-4
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:Mitochondria produce cellular energy via oxidative phosphorylation (OXPHOS), mediated by respiratory chain complexes I to IV and ATP synthase (complex V). Mitochondrial respiratory complexes have been shown to decline with age in several tissues. As the intestinal epithelium is a tissue with a high energy dem...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.110924
更新日期:2020-07-01 00:00:00
abstract::Aging has a profound effect on the immune system, and both innate and adaptive arms of the immune system show functional decline with age. In response to infection with intracellular microorganisms, old animals mobilize decreased numbers of antigen-specific CD8+ T cells with reduced production of effector molecules an...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2018.01.011
更新日期:2018-05-01 00:00:00
abstract::An age-related increase of DNA damage/mutation has been previously reported in human lymphocytes. The high copy number and mutation rate make the mtDNA genome an ideal candidate for assessing damage and to act as a potential biomarker of ageing. In the present study, two assays were developed to evaluate the level of ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(01)00200-5
更新日期:2002-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.08.018
更新日期:2017-11-01 00:00:00
abstract::As a major intracellular source of reactive oxygen species (ROS), mitochondria are involved in aging and lifespan regulation. Using the yeast chronological aging model, researchers have identified conserved signaling pathways that affect lifespan by modulating mitochondrial functions. Caloric restriction and a genetic...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2011.08.007
更新日期:2011-11-01 00:00:00
abstract::Degeneration of tongue muscles with aging may contribute to swallowing deficits observed in elderly people. However, the capacity for tongue muscle stem cells (SCs) to regenerate and repair the aged tongue and improve tongue strength following tongue exercise (a current clinical treatment) has never been examined. We ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.111104
更新日期:2020-12-01 00:00:00
abstract::Alzheimer's disease (AD) is characterized by the accumulation and aggregation of misfolded proteins. The presence of misfolded proteins in the endoplasmic reticulum (ER) triggers a cellular stress response called the unfolded protein response (UPR). Previously, we have shown that the UPR is activated in AD neurons. In...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2006.01.013
更新日期:2006-04-01 00:00:00
abstract::A colony of male Lakeview Golden (LVG) Syrian hamsters has been maintained for the last nine years as a source of various tissues for cellular aging studies. Observations on this colony also yielded data on survival time and physical and pathological manifestations of aging in this strain. Based on 150 spontaneous dea...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(90)90032-w
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:An intermission in the training routine, in which older adults refrain from regular structured exercise, may have deleterious effects on muscle performance and bioelectric phase angle (PhA), which is a predictive marker for cellular integrity. PURPOSE:To determine the effects of a 2-week detraining period o...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.111175
更新日期:2021-02-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2015.08.011
更新日期:2015-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1982-01-01 00:00:00
abstract::Fragility fractures due to osteoporosis and its most dreaded complication - hip fractures - are the cause of disability, high mortality and place a considerable burden on global health economics. Although much work has been done to accurately predict mortality and find risk factors for poor health outcome, little atte...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.06.002
更新日期:2017-10-01 00:00:00
abstract:BACKGROUNDS:Elucidating the causal effects of common intermediate risk factors on the onset of age-related diseases is indispensable for developing prevention and intervention procedures. METHODS:We conducted two-stage time-to-event Mendelian randomization meta-analyses combining five large-scale longitudinal cohorts ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.09.019
更新日期:2018-07-01 00:00:00
abstract::Reductions in physical performance, cognitive impairment (CI) and decline (CD), are common in older age, but few prospective cohort studies have considered the relationship between these domains. In this study we investigated whether reduced physical performance and low handgrip/lower limbs strength, could predict a h...
journal_title:Experimental gerontology
pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00
abstract:OBJECTIVES:To evaluate lean mass index (LMI) measured by bioimpedance (BIA) and anthropometry compared to densitometry (DXA) in elderly outpatients from a tertiary care hospital. METHODS:Participants were over 60-year-old men, presenting no dementia or disability, from a tertiary geriatric ambulatory. LMI obtained by ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.111020
更新日期:2020-09-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2020.111220
更新日期:2021-03-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2005.07.003
更新日期:2005-08-01 00:00:00
abstract::The binding of advanced glycation endproducts (AGEs) to their receptors is known to cause changes in cell function during normal ageing and is implicated in the pathogenesis of cardiovascular disease. In this study, expression of the AGE-receptor 3 (AGE-R3) and the receptor for AGEs (RAGE) was compared on the mRNA and...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2003.12.006
更新日期:2004-03-01 00:00:00
abstract::Accumulating evidence from diverse experiments, including heterochronic parabiosis-the surgical joining of two animals of different ages-has highlighted the importance of systemic factors in the progressive functional decline of various organs and tissues during aging. The major metabolic pathway of tryptophan, an ess...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2019.110793
更新日期:2020-02-01 00:00:00