Abstract：
:Aging has a profound effect on the immune system, and both innate and adaptive arms of the immune system show functional decline with age. In response to infection with intracellular microorganisms, old animals mobilize decreased numbers of antigen-specific CD8+ T cells with reduced production of effector molecules and impaired cytolytic activity. However, the CD8+ T cell-intrinsic contribution to, and molecular mechanisms behind, these defects remain unclear. In this review we will discuss the mechanistic contributions of age related changes in the CD8+ T cell pool and the relative roles of intrinsic functional defects in aged CD8+ T cells vs. defects in the aged environment initiating the CD8+ T cell response.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Jergović M,Smithey MJ,Nikolich-Žugich Jdoi
10.1016/j.exger.2018.01.011subject
Has Abstractpub_date
2018-05-01 00:00:00pages
140-145eissn
0531-5565issn
1873-6815pii
S0531-5565(17)30794-5journal_volume
105pub_type
杂志文章,评审abstract：:It is now widely recognized that in order to optimize bone health in the later years, bone healthy behaviors should begin at a young age and continue throughout life. Prescribed orally to lower lipid levels in adults of all ages, statins have also been shown to stimulate bone formation in vitro by promoting bone morph...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.04.007
更新日期：2013-08-01 00:00:00
abstract：:Aromatase inhibitors have become the standard of care for the adjuvant treatment of postmenopausal, hormone-sensitive breast cancer. Meanwhile, more and more breast cancer patients who are treated with aromatase inhibitors as adjuvant therapies often experience arthralgias and musculoskeletal aching, in some cases, ha...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.03.003
更新日期：2009-06-01 00:00:00
abstract：:In this study, spontaneous multiple unit activity (MUA, action potentials derived simultaneously from a number of neurons in a given brain region) was recorded through electrodes chronically implanted in the parietal cerebral cortex of the rats of 1, 3, 6, 9, 12, and 26 months of age (cross-sectional study). Electroph...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(88)90003-4
更新日期：1988-01-01 00:00:00
abstract：:Aging is the primary risk factor for functional decline; thus, understanding and preventing disability among older adults has emerged as an important public health challenge of the 21st century. The science of gerontology - or geroscience - has the practical purpose of "adding life to the years." The overall goal of g...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2020.111123
更新日期：2020-12-01 00:00:00
abstract：:The abundance of a selection of transcript species involved in inflammation, immunosenescence and stress response was compared between PBMC of 35 geriatric patients with hip fracture in acute phase (days 2-4 after hospitalization) or convalescence phase (days 7-10) and 28 healthy aged controls. Twenty-nine differentia...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2010.10.012
更新日期：2011-04-01 00:00:00
abstract：:Muscle wasting diseases are gradually increasing with the increase in global life expectancy. This study was designed to evaluate the efficacy of HIM-CHX, a herbal combination of Boswellia serrata, Cissus quadrangularis, and Withania somnifera, on Sarcopenia. The effects of HIM-CHX on parameters such as muscle mass, g...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.110663
更新日期：2019-10-01 00:00:00
abstract：:Primary human dermal fibroblasts isolated from the medial aspect of the proximal forearm of young and old donors were compared for the expression of interstitial collagenase, 72 kDa type IV collagenase, the tissue inhibitor of metalloproteinase type 1, and pro-alpha 2 (I) collagen mRNA at basal levels and after stimul...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(94)90061-2
更新日期：1994-01-01 00:00:00
abstract：:It is well established that the proliferative potential of the liver declines with aging. Epidermal growth factor (EGF)-stimulated DNA synthesis is reduced in hepatocytes from aged rats relative to young rats, and this reduction correlates with diminished activation of the extracellular signal-regulated kinase (ERK) p...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(02)00239-5
更新日期：2003-04-01 00:00:00
abstract：:We have analyzed birth records from the International Species Inventory System database of zoo animals to describe patterns of fertility as a function of age in birds and mammals. Unlike age at death, fertility in captive populations is partly controlled by animal keepers depending on availability of space and potenti...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(03)00101-3
更新日期：2003-07-01 00:00:00
abstract：:The effects of long-term treatment with both antioxidants and a program of behavioral enrichment were studied as part of a longitudinal investigation of cognitive aging in beagle dogs. Baseline performance on a battery of cognitive tests was used to assign 48 aged dogs (9-12 years) into four cognitively equivalent gro...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.01.007
更新日期：2004-05-01 00:00:00
abstract：:One of the most remarkable life history traits of many species of eusocial insects is the extraordinary longevity of their queens, with the recorded life span of some individuals exceeding 30 years. Surprisingly, little research has been conducted on either the proximate or ultimate questions concerning what factors f...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(00)00237-0
更新日期：2001-04-01 00:00:00
abstract：:Age-related changes in cancer mortality risk are important for understanding the processes of disease and aging interaction. The extent to which these age changes differ by sex further contributes to this understanding but has not been well studied to date. We conducted a systematic examination of dynamics and heterog...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2012.06.009
更新日期：2012-09-01 00:00:00
abstract：:This study was designed to investigate whether the relationship of fiber size and force is maintained with aging and inactivity. We hypothesized that fiber size and fiber force-generating capacity would decrease in parallel, thus resulting in no change in specific force with either age or inactivity. Thirty male Fisch...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.12.002
更新日期：2005-03-01 00:00:00
abstract：OBJECTIVE:Depression is common in hemodialysis patients. Reduced DHEA-S levels have been shown to be associated with depression in general population. Abnormalities in hormone production and metabolism are found in hemodialysis patients. However, the association between DHEA-S levels and depression in hemodialysis pati...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.08.009
更新日期：2009-11-01 00:00:00
abstract：:We have developed a simian virus 40 (SV40) T-antigen immortalized human cell line, 1MR90-D305.2H4 (IDH4), in which the expression of T-antigen is controlled by the mouse mammary tumor virus (MMTV) promoter and thus regulated by steroids such as dexamethasone. Studies on the regulation of proliferation by T-antigen led...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(92)90003-i
更新日期：1992-09-01 00:00:00
abstract：OBJECTIVE:Senescent patients exhibit an elevated perioperative risk for cardiac dysfunction, hemodynamic depression and subsequent cardiac death compared to young patients. Despite the fact that a growing proportion of cardiac surgery patients are octogenarians, cardioplegic regimes remain comparable across patients of...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.04.012
更新日期：2015-07-01 00:00:00
abstract：:The long life spans and slow aging rates of birds relative to mammals are paradoxical in view of birds' high metabolic rates, body temperatures and blood glucose levels, all of which are predicted to be liabilities by current biochemical theories of aging. Available avian life-table data show that most birds undergo r...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(00)00247-3
更新日期：2001-04-01 00:00:00
abstract：:The maximal lifespan (MLS) of mammals is inversely correlated with the peroxidation index, a measure of the proportion and level of unsaturation of polyunsaturated fatty acids (PUFA) in membranes. This relationship is likely related to the fact that PUFA are highly susceptible to damage by peroxidation. Previous compa...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.08.011
更新日期：2015-10-01 00:00:00
abstract：INTRODUCTION:Right ventricular dysfunction (RVD), submassive pulmonary embolism (PE), elevated systolic pulmonary artery pressure (sPAP), elevated cardiac troponin I (cTnI) and old age are well-known risk factors for poor outcome in acute normotensive PE. The aim of this analysis was to calculate age cut-off values to ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.05.007
更新日期：2015-09-01 00:00:00
abstract：:Diabetic peripheral neuropathy (DPN) is associated with peripheral arterial disease and endothelial dysfunction. We investigated the effect of exercise training on the measures of superficial femoral artery (SFA) and neuropathic symptoms in patients with DPN. In a randomized-controlled trial, 31 volunteers with establ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.110799
更新日期：2020-03-01 00:00:00
abstract：:Dietary restriction (DR) has multiple and essential effects in protecting against DNA damage in model organisms. Persistent DNA damage plays a central role in the process of aging. Senescence-associated secretory phenotype (SASP), as a product of cellular aging, can accelerate the process of cellular senescence as a f...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.09.005
更新日期：2018-07-01 00:00:00
abstract：:Non-insulin dependent diabetes mellitus (NIDDM) has been associated with a number of physiological consequences including neuropathy, retinopathy and incidence of vascular disease. Recently, several authors reviewed studies that suggested that NIDDM is associated with cognitive impairments leading to a higher incidenc...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(03)00153-0
更新日期：2003-09-01 00:00:00
abstract：:In many eukaryotes oxidative phosphorylation via the mitochondrial electron transport chain provides the major means of ATP production. Complete removal of this capacity often results in premature death. Recent studies using the nematode Caenorhabditis elegans are surprising because they have revealed that disruption ...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2005.06.015
更新日期：2005-11-01 00:00:00
abstract：:Coenzyme Q10 supplementation increases life-span of rats fed on a diet enriched with polyunsaturated fatty acids (Quiles, J.L., Ochoa, J.J., Huertas, J.R., Mataix, J., 2004b. Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increased lifespan in rats fed on a PUFA-rich diet. Exp. Geron...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2005.07.003
更新日期：2005-08-01 00:00:00
abstract：:Several papers reported in recent years on a change in the age population distribution of the circulating erythrocytes in old mice, rats, rabbits, and humans. The results indicate the presence of a chronologically younger cell population in old animals and humans. The cells are typically lower in density and larger. I...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(92)90055-5
更新日期：1992-01-01 00:00:00
abstract：:Increased lifespan can be associated with greater resistance to many different stressors, most notably thermal stress. Such hormetic effects have also been found in C. elegans where short-term exposure to heat lengthens the lifespan. Genetic investigations have been carried out using mutation perturbations in a single...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2012.05.005
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVE:This study aimed to evaluate the effect of vitamin D3 megadose supplementation and influence of BsmI polymorphism in the VDR gene on the inflammatory profile and oxidative stress in elderly women with vitamin D deficiency. METHODS:A double blind, randomized, placebo-controlled trial was conducted with 40 eld...
journal_title：Experimental gerontology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.exger.2015.03.011
更新日期：2015-06-01 00:00:00
abstract：:According to the free radical theory of aging, free radicals are involved in the production of changes in cellular metabolism that lead to a time-dependent functional decline in all living beings. Consequently, antioxidant and/or free radicals scavengers may retard the aging process. We explored the effect of melatoni...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(01)00229-7
更新日期：2002-05-01 00:00:00
abstract：:Impaired tolerance to ischemia-reperfusion in older hearts may stem in part from alterations in purine catabolism, impacting on maintenance of energy state and protective signaling via extracellular adenosine. We characterized effects of aging on normoxic and post-ischemic purine metabolism in hearts from young (2-4 m...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2003.08.003
更新日期：2003-10-01 00:00:00
abstract：:Ageing is defined as the loss of ability to maintain cellular homeostasis of an organism associated with the free radical-elicited oxidative damage to cellular macromolecules. The aim of this study was to evaluate the efficacy of epigallocatechin-3-gallate (EGCG), the key component of green tea catechins on attenuatin...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2007.10.017
更新日期：2008-03-01 00:00:00
