Abstract：
:Dietary restriction (DR) has multiple and essential effects in protecting against DNA damage in model organisms. Persistent DNA damage plays a central role in the process of aging. Senescence-associated secretory phenotype (SASP), as a product of cellular aging, can accelerate the process of cellular senescence as a feedback. In this study, we directly observed whether a DR of 30% for 6months in aged rats could retard SASP by delaying the progression of DNA damage and also found the specific mechanism. The results revealed that a 30% DR could significantly improve renal pathology and some metabolic characteristics. The biomarkers and products of DNA damage were decreased in the process of renal aging on a 30% DR. A series of SASP, notably cytokine, chemokine, and growth factor, were obviously reduced by DR during renal aging. The phosphorylation levels of NF-κB and IκBα in aged kidneys of DR group were markedly reduced. These findings suggest that a 30% DR for 6months can delay renal aging and reduce the accumulation of SASP by retarding the progression of DNA damage and decreasing the transcription activity of NF-κB, thus providing a target to delay renal aging.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Wang W,Cai G,Chen Xdoi
10.1016/j.exger.2017.09.005subject
Has Abstractpub_date
2018-07-01 00:00:00pages
4-10eissn
0531-5565issn
1873-6815pii
S0531-5565(17)30380-7journal_volume
107pub_type
杂志文章abstract：:The mechanisms responsible for age-associated hearing loss are still incompletely characterized. In this study, we used a murine model of age-dependent hearing loss and evaluated whether this condition is associated with vascular modifications of the structures of the inner ear. We used old C57BL/6J mice that are affe...
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pub_type： 临床试验,杂志文章
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更新日期：2010-01-01 00:00:00
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pub_type： 杂志文章,评审
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abstract：:Culturing Caenorhabditis elegans in axenic medium leads to a twofold increase in lifespan and considering the similar phenotypical traits with dietary restricted animals, it is referred to as axenic dietary restriction (ADR). The free radical theory of aging has suggested a pivotal role for mitochondria in the aging p...
journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：2014-08-01 00:00:00
