Abstract：
:This study was designed to investigate whether the relationship of fiber size and force is maintained with aging and inactivity. We hypothesized that fiber size and fiber force-generating capacity would decrease in parallel, thus resulting in no change in specific force with either age or inactivity. Thirty male Fischer 344/Brown Norway F1 hybrid rats, 6-23-month old (young adult), 24-33-month old (middle-aged) and 34-40 month old (old) were hindlimb unweighted for 14 days. Single permeabilized type I fibers from the soleus and gastrocnemius muscles were evaluated for size and contractile function. The diameter of the fibers from the soleus muscle declined with age and unweighting. In contrast, the fibers from the gastrocnemius showed no age-related atrophy. In both the soleus and gastrocnemius, there was a significant decrease in the force generation with age and unweighting. When comparing size and peak absolute force in the type I fibers from control young and middle-aged animals a positive relationship was observed whereas no significant relationship between size and peak absolute force was observed in the old animals. Following unweighting, fibers from young and middle aged rats showed a significant relationship between force and size. Fibers from old animals did not exhibit a relationship between size and force following unweighting. These results suggest aged skeletal muscle has an attenuated ability to adapt to inactivity by altering its size in response to inactivity.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Husom AD,Ferrington DA,Thompson LVdoi
10.1016/j.exger.2004.12.002keywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
227-35issue
3eissn
0531-5565issn
1873-6815pii
S0531-5565(04)00349-3journal_volume
40pub_type
杂志文章abstract：:Diabetic peripheral neuropathy (DPN) is associated with peripheral arterial disease and endothelial dysfunction. We investigated the effect of exercise training on the measures of superficial femoral artery (SFA) and neuropathic symptoms in patients with DPN. In a randomized-controlled trial, 31 volunteers with establ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.110799
更新日期：2020-03-01 00:00:00
abstract：:The Tokyo Metropolitan Institute of Gerontology (TMIG) celebrates its 30th anniversary in 2002. Since its establishment, TMIG has been carrying out inter-disciplinary research on aging as a core institute in Japan and functions as a knowledge bank and a source for capable researchers of gerontology. The proportion of ...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(02)00169-9
更新日期：2002-12-01 00:00:00
abstract：:Ascorbic acid decreases from age-group I to II in Kidney, skeletal muscle, and increases in the Pancreas of female. There is no significant change in the Pancreas of male toad. There is an increase in the ascorbic acid content from age group II to III except in the Pancreas of females, where there is a decline of the ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(84)90011-1
更新日期：1984-01-01 00:00:00
abstract：:The aim of this study was to compare voluntary and involuntary force generating capacity of the triceps surae muscles in healthy young and older adult participants during isometric and isokinetic contractions. Ultrasound was used to measure medial gastrocnemius (MG) fascicle length during maximal voluntary isometric c...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.07.007
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Longitudinal studies on sleep duration and grip strength decline are limited. This study aimed to evaluate the associations of baseline sleep duration with follow-up grip strength and grip strength changeover time among a large sample of middle-aged and older Chinese. METHODS:Data from China Health and Reti...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2018.01.009
更新日期：2018-03-01 00:00:00
abstract：:To understand the mechanism of aging at the cellular level, cellular senescence has been extensively studied as an experimental model of aging in vitro. Although several hypotheses have been proposed for the mechanism of cellular senescence, none of them could give a comprehensive framework to the mechanism. In this s...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(98)00008-4
更新日期：1998-08-01 00:00:00
abstract：:A revolution has occurred in the attitude of biologists toward their intellectual property rights. What today is patentable and highly profitable was, 20 years ago, unpatentable and given away for nothing. The history of this revolution began in the early 1960s when we made the first effort to have self-duplicating ce...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(97)00115-0
更新日期：1998-01-01 00:00:00
abstract：:The purpose of this study was to examine the relative contributions of changes in muscle quality and body composition to changes in lower-extremity physical function (LEPF) following a 6-month exercise and weight loss intervention in overweight and obese older women. Thirty-eight overweight and obese (BMI = 30.0 ± 4.4...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2018.04.011
更新日期：2018-07-15 00:00:00
abstract：:While influenza immunization significantly reduces the risk of pneumonia and associated deaths, vaccination of elderly only affords 30-50% protection against influenza disease. The purpose of this study was to: (1) evaluate the consistency of immune responses across multiple years in young and elderly; (2) determine t...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(01)00210-8
更新日期：2002-01-01 00:00:00
abstract：:Cytogenetic analysis of the X chromosome in phytohaemagglutinin stimulated peripheral blood lymphocytes was evaluated in 12 sporadic Alzheimer disease (AD) patients and in 11 healthy subjects. For chromosome analysis two methods were used: (1) standard analysis of G-banded metaphase chromosomes and; (2) fluorescent in...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.01.012
更新日期：2004-05-01 00:00:00
abstract：:Aging plays an important role in increased vulnerability to atrial fibrillation (AF). Mediated by activity at the muscarinic type 2 receptor (M2R), the parasympathetic nerve contributes to the onset of AF. The purpose of this study was to investigate whether aging changes the distribution of M2R in the atrial myocardi...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.06.002
更新日期：2009-09-01 00:00:00
abstract：:Centenarians are people who escaped from major common diseases, including cancer, and reached the extreme limits of human life-span. The analysis of demographic data indicates that cancer incidence and mortality show a levelling off around the age of 85-90 years, and suggests that oldest old people and centenarians ar...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(02)00137-7
更新日期：2002-10-01 00:00:00
abstract：:The age-associated decline in the regenerative abilities of mesenchymal stem cells (MSCs) may be due to age-related changes in reduction in number, intrinsic properties of MSCs and extrinsic factors of the extracellular environment (the stem cell niche). The effect of age on the efficacy of MSC transplantation on rege...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.01.020
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:Several studies reported an association between concentrations of serum uric acid and cognitive function, but the evidence is contradictory. It is known that uric acid is associated with cardiovascular diseases, especially among women. Stratifying by sex and history of cardiovascular disease may clarify whet...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.04.017
更新日期：2016-08-01 00:00:00
abstract：:We investigated the effect of resistance training on irisin expression with improvement in muscle strength and function in aged mice and human. In the mice study, 19 months old male C57BL/6 mice were randomly assigned into two groups; control group and resistance exercise group. Ladder climbing exercise with tail weig...
journal_title：Experimental gerontology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.exger.2015.07.006
更新日期：2015-10-01 00:00:00
abstract：:Proteomic analysis is defined as the characterization of the entire set of proteins encoded by a genome. Two-dimensional (2D) electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) are key technologies used in proteomic analysis to gain information about protein...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.04.003
更新日期：2004-08-01 00:00:00
abstract：BACKGROUND:Self-report questionnaires are widely used to assess physical function in older adults. However, they often lack a clear frame of reference and hence interpreting and rating task difficulty levels can be problematic for the responder. Consequently, the usefulness of traditional self-report questionnaires for...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.04.022
更新日期：2016-08-01 00:00:00
abstract：:Aging is associated with an increased incidence of heart failure, but the existence of an age-related cardiomyopathy remains controversial. Differences in strain, age and technique of measuring cardiac function differ between experiments, confounding the interpretation of these studies. Additionally, the structural an...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2011.02.010
更新日期：2011-07-01 00:00:00
abstract：:Life history theory proposes that menopause is either an epiphenomenon or an adaptation. The most recent adaptive hypothesis proposes that menopause in humans has evolved because of conflict between reproducing generations (RCH). Overlapping reproduction between generations may impose fitness costs to older and younge...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.02.001
更新日期：2013-04-01 00:00:00
abstract：:Long-lived recombinant inbred lines, some of which have mean and maximum life spans up to 70% longer than wild type, were used in these analyses. Longer life results from a slower exponential rate of increase in mortality. General motor activity decreases with chronological age in all genotypes; this decay in general ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(88)90031-9
更新日期：1988-01-01 00:00:00
abstract：:SIRT1 is a highly conserved NAD(+)-dependent protein deacetylase known to have protective effects against a variety of age-related diseases. However, there is a lack of information concerning SIRT1 expression in the cochlea and auditory cortex of C57BL/6 mice, a mouse model of age-related hearing loss. Using RT-PCR an...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.12.006
更新日期：2014-03-01 00:00:00
abstract：:The CG9940 gene, which encodes the NAD(+) synthase protein in Drosophila, is conserved in human, zebra fish, and mosquito. NAD(+) synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic a...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.07.006
更新日期：2016-10-01 00:00:00
abstract：:Adult Premature Aging Mice (PAM) show premature immunosenescence, oxidative and inflammatory stress and consequently a shorter lifespan than Exceptional Non-Prematurely Aging Mice (E-NPAM) at the same age. Indeed, adult female PAM exhibit behavioral age-related declines and abnormalities in its brain neurochemistry. N...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111224
更新日期：2020-12-31 00:00:00
abstract：:The Senescence-Accelerated Mouse (SAM) strains are unique and appropriate models for genetic studies on aging because the SAMP strains have an "accelerated senescence" phenotype for which the SAMR strains are controls, and each SAMP strain has a strain-specific age-associated disorder. Furthermore, because they have g...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(96)00060-5
更新日期：1997-01-01 00:00:00
abstract：:Intracellular Ca(2+) signaling is important to perfusion pressure related arterial reactivity and to vascular disorders including hypertension, angina and ischemic stroke. We have recently shown that advancing-age leads to calcium signaling adaptations in mesenteric arterial myocytes from C57 BL/6 mice [Corsso, C.D., ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2008.10.007
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND/AIM:Age-related metabolic diseases are often associated with low-grade inflammation. The aim of the present study was to investigate the role of the transcriptional co-activator PGC-1α in the potential beneficial effects of exercise training and/or resveratrol in the prevention of age-associated low-grade in...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.07.015
更新日期：2013-11-01 00:00:00
abstract：:To understand the mechanisms that control life span and age-related phenotypes, we used two-dimensional (2D) gel electrophoresis to study the intracellular proteins whose amounts change during the process of cellular aging. We found that the amount of an alpha-2-macroglobulin (A2M) fragment derived from culture medium...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00256-4
更新日期：2001-03-01 00:00:00
abstract：:Rapamycin consistently increases longevity in mice although the mechanism of action of this drug is unknown. In the present investigation we studied the effect of rapamycin on mitochondrial oxidative stress at the same dose that is known to increase longevity in mice (14mgofrapamycin/kg of diet). Middle aged mice (16m...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.08.002
更新日期：2016-10-01 00:00:00
abstract：:Rodent gerontology experiments should be carefully designed and correctly analyzed so as to provide the maximum amount of information for the minimum amount of work. There are five criteria for a "good" experimental design. These are applicable both to in vivo and in vitro experiments: (1) The experiment should be unb...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(96)00032-0
更新日期：1997-01-01 00:00:00
abstract：:The immune response declines with age. This decline correlates with thymic involution and involves primarily a loss in T-cell function, whereas humoral immunity is more variably affected. In the current experiments we have measured immunoglobulin synthesis in vitro after mitogen stimulation, and specific antibody resp...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(86)90017-3
更新日期：1986-01-01 00:00:00
