当前位置： SCI文献检索 > EXPERIMENTAL GERONTOLOGY期刊下所有文献 > Association of cognitive function and serum uric acid: Are cardiovascular diseases a mediator among women?

Association of cognitive function and serum uric acid: Are cardiovascular diseases a mediator among women?

Abstract：

BACKGROUND:Several studies reported an association between concentrations of serum uric acid and cognitive function, but the evidence is contradictory. It is known that uric acid is associated with cardiovascular diseases, especially among women. Stratifying by sex and history of cardiovascular disease may clarify whether uric acid is an independent risk factor for cognitive dysfunction. METHODS:A population-based study was conducted in the German State of Saarland. A subgroup of participants aged ≥70years underwent a comprehensive assessment of cognitive function. Linear regression models and restricted cubic spline functions were used to assess association of uric acid with cognitive performance in 1144 study participants. RESULTS:High levels of uric acid were associated with worse cognitive performance among women (-0.57; 95% CI: -1.10 to -0.04) but not among men (-0.12; 95% CI: -0.64 to 0.39). The association was much stronger among the subgroup of women with cardiovascular diseases (-1.91; 95% CI: -3.15 to -0.67) and also revealed a dose-response relationship in this subgroup. CONCLUSIONS:Serum uric acid showed an inverse association with cognitive function among women and the association was amplified by the presence of cardiovascular disease. These results highlight the importance of stratifying by sex and cardiovascular disease in future studies on uric acid and cognition.

journal_name

Exp Gerontol

journal_title

Experimental gerontology

authors

Perna L,Mons U,Schöttker B,Brenner H

doi

10.1016/j.exger.2016.04.017

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

37-41

eissn

0531-5565

issn

1873-6815

pii

S0531-5565(16)30113-9

journal_volume

81

pub_type

杂志文章

相关文献

EXPERIMENTAL GERONTOLOGY文献大全
  • Adherence to the Mediterranean diet, dietary factors, and S-Klotho plasma levels in sedentary middle-aged adults.

    abstract：INTRODUCTION:The ageing process can be influenced by different dietary patterns and dietary factors. AIM:To analyse the association of dietary factors, which include the Mediterranean diet adherence, the compliance with the "Sociedad Española de Nutrición Comunitaria" food portion recommendations, and the intake of di...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2019.01.019

    authors： Jurado-Fasoli L,Amaro-Gahete FJ,De-la-O A,Martinez-Tellez B,Ruiz JR,Gutiérrez Á,Castillo MJ

    更新日期：2019-05-01 00:00:00

  • Two-dimensional gel electrophoretic studies on the cellular aging: accumulation of alpha-2-macroglobulin in human fibroblasts with aging.

    abstract：:To understand the mechanisms that control life span and age-related phenotypes, we used two-dimensional (2D) gel electrophoresis to study the intracellular proteins whose amounts change during the process of cellular aging. We found that the amount of an alpha-2-macroglobulin (A2M) fragment derived from culture medium...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/s0531-5565(00)00256-4

    authors： Kondo T,Sakaguchi M,Namba M

    更新日期：2001-03-01 00:00:00

  • No additional effect of different types of physical activity on 10-hour muscle protein synthesis in elderly men on a controlled energy- and protein-sufficient diet.

    abstract：PURPOSE:The elderly lose skeletal muscle mass with age, which may be detrimental for function and quality of life. Both inactivity and heavy resistance exercise are known to have marked but opposite effects upon muscle mass. However, the potential effects of daily physical activity upon muscle protein synthesis (MPS) a...

    journal_title：Experimental gerontology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.exger.2016.03.008

    authors： Bülow J,Agergaard J,Kjaer M,Holm L,Reitelseder S

    更新日期：2016-06-15 00:00:00

  • Stress, DNA damage and ageing -- an integrative approach.

    abstract：:Ageing is highly complex, involving multiple mechanisms at different levels. Nevertheless, recent evidence suggests that several of the most important mechanisms are linked via endogenous stress-induced DNA damage caused by reactive oxygen species (ROS). Understanding how such damage contributes to age-related changes...

    journal_title：Experimental gerontology

    pub_type： 杂志文章,评审

    doi：10.1016/s0531-5565(01)00111-5

    authors： von Zglinicki T,Bürkle A,Kirkwood TB

    更新日期：2001-07-01 00:00:00

  • Studies on the molecular-genetic basis of replicative senescence in Werner syndrome and normal fibroblasts.

    abstract：:Based on evidence that human diploid fibroblasts (HDF) from the Werner syndrome (WS) of premature aging might overexpress an inhibitor of DNA synthesis (IDS), we prepared a eukaryotic cDNA expression library from WS mRNA and tested it for IDS activity in a transient assay. Two of six WS cDNA pools tested gave IDS acti...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/0531-5565(89)90052-1

    authors： Goldstein S,Murano S,Benes H,Moerman EJ,Jones RA,Thweatt R,Shmookler Reis RJ,Howard BH

    更新日期：1989-01-01 00:00:00

  • Effect of centrophenoxine on the antioxidative enzymes in various regions of the aging rat brain.

    abstract：:This study investigated the effect (in vivo) of centrophenoxine (Helfergin) on the activity of antioxidant enzymes (glutathione peroxidase GSH-PER, glutathione reductase GSSG-RED, superoxide dismutase SOD and catalase) in subcellular fractions from the regions of the brain (cerebrum, cerebellum and brain stem) of rats...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/0531-5565(83)90031-1

    authors： Roy D,Pathak DN,Singh R

    更新日期：1983-01-01 00:00:00

  • Strain-dependent response to stimulation in middle-aged rat macrophages: A quest after a useful indicator of healthy aging.

    abstract：:Rats of Albino Oxford (AO) strain in our animal facility exhibit a longer average healthy life span than rats of Dark Agouit (DA) strain. Since chronic activation of macrophages contributes to chronic low level inflammation common in older age, elucidation of the changes in middle-aged rats could be useful in preventi...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2016.10.005

    authors： Stanojević S,Ćuruvija I,Blagojević V,Petrović R,Vujić V,Dimitrijević M

    更新日期：2016-12-01 00:00:00

  • Central markers of body fat distribution are important predictors of plasma lipids in elderly men and women.

    abstract：:We determined the contribution of body fat distribution, peak VO2, fat mass, and dietary intake to variation in plasma lipids in elderly individuals. Volunteers were a healthy cohort of older Caucasian women (n = 75, mean age +/- SD, 72 +/- 5 years) and older men (n = 101, 72 +/- 5 years). We determined fat mass from ...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/s0531-5565(97)00052-1

    authors： Obisesan TO,Toth MJ,Ades PA,Poehlman ET

    更新日期：1997-11-01 00:00:00

  • A novel neurocognitive approach for placebo analgesia in neurocognitive disorders.

    abstract：:Neural correlates of placebo analgesia (PA) in patients with neurocognitive disorders have not yet been elucidated. The present study aimed to evaluate how and to what extent executive (dys)functions of the medial prefrontal cortex (MPFC) may be related to PA. To this end, twenty-three subjects complaining of differen...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2019.01.011

    authors： Palermo S,Rainero I,Stanziano M,Vase L,D'Agata F,Rubino E,Fonio P,Sardanelli F,Amanzio M

    更新日期：2019-04-01 00:00:00

  • Evidence for oxidative and not reductive stress in the aged rabbit heart.

    abstract：:Reductive stress, which is due to a paradoxical excess of antioxidants such as reduced glutathione (GSH) and GSH-related enzymes associated with decreased oxidant levels, has emerged as a pathogenetic mechanism of myocardial damage in pathological conditions such as protein aggregation cardiomyopathy. Notably, in the ...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2020.110871

    authors： Lapenna D,Ciofani G,Lelli Chiesa P,Porreca E

    更新日期：2020-02-06 00:00:00

  • CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.

    abstract：OBJECTIVE:Hippocampal sclerosis of aging (HS-Aging) is a common cause of dementia in older adults. We tested the variability in cerebrospinal fluid (CSF) proteins associated with previously identified HS-Aging risk single nucleotide polymorphisms (SNPs). METHODS:Alzheimer's Disease Neuroimaging Initiative cohort (ADNI...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2017.01.025

    authors： Fardo DW,Katsumata Y,Kauwe JSK,Deming Y,Harari O,Cruchaga C,Alzheimer's Disease Neuroimaging Initiative.,Nelson PT

    更新日期：2017-04-01 00:00:00

  • Pharmacological investigation of 'HIM-CHX': A herbal combination in the experimental muscle wasting condition.

    abstract：:Muscle wasting diseases are gradually increasing with the increase in global life expectancy. This study was designed to evaluate the efficacy of HIM-CHX, a herbal combination of Boswellia serrata, Cissus quadrangularis, and Withania somnifera, on Sarcopenia. The effects of HIM-CHX on parameters such as muscle mass, g...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2019.110663

    authors： Azeemuddin MM,Rao CM,Rafiq M,Babu UV,Rangesh P

    更新日期：2019-10-01 00:00:00

  • The mitochondrial O-linked N-acetylglucosamine transferase (mOGT) in the diabetic patient could be the initial trigger to develop Alzheimer disease.

    abstract：:Diabetes mellitus (DM) is considered a risk factor for the development of Alzheimer disease (AD); however, how DM favors evolution of AD is still insufficiently understood. Hyperglycemia in DM is associated to an increase in mitochondrial reactive oxygen species (ROS) generation, as well as damage of hippocampal cells...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2014.08.008

    authors： Lozano L,Lara-Lemus R,Zenteno E,Alvarado-Vásquez N

    更新日期：2014-10-01 00:00:00

  • Cluster-sets resistance training induce similar functional and strength improvements than the traditional method in postmenopausal and elderly women.

    abstract：OBJECTIVE:The aim of this study was to compare the effects of 12 weeks of traditional resistance training (TRT) or resistance training using Cluster-set (CS) on functional performance and physical fitness of postmenopausal and elderly women. METHODS:Participants (61.1 ± 4.9 years, body mass 64.5 ± 1.8 kg, height 155.7...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2020.111011

    authors： Dias RKN,Penna EM,Noronha ASN,de Azevedo ABC,Barbalho M,Gentil PV,Coswig VS

    更新日期：2020-09-01 00:00:00

  • Force-velocity profiling in older adults: An adequate tool for the management of functional trajectories with aging.

    abstract：INTRODUCTION:The actual mechanisms leading to a reduced muscle power and functional ability in older adults are poorly understood. We investigated the association between different force-velocity (F-V) profiles and impaired muscle power, physical and cognitive function, frailty, and health-related quality of life (HRQo...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2018.03.015

    authors： Alcazar J,Rodriguez-Lopez C,Ara I,Alfaro-Acha A,Rodríguez-Gómez I,Navarro-Cruz R,Losa-Reyna J,García-García FJ,Alegre LM

    更新日期：2018-07-15 00:00:00

  • Quantitation of sex-specific serum N-glycome changes in expression level during mouse aging based on Bionic Glycome method.

    abstract：:Studying the changes of serum N-glycome during mouse aging is beneficial to explore the molecular basis behind the alterations reported in human. However, such studies remainscarce and lack some information such as sialylation due to the method limitation. Here, we introduced Bionic Glycome method to quantify the seru...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2020.111098

    authors： Han J,Pan Y,Qin W,Gu Y,Xu X,Zhao R,Sha J,Zhang R,Gu J,Ren S

    更新日期：2020-11-01 00:00:00

  • The evolution of ovarian oocyte decline with aging and possible relationships to Down syndrome and Alzheimer disease.

    abstract：:Evolutionary aspects of menopause are considered from several perspectives. First, the programmed exhaustion of ovarian oocytes appears to be a general trait of mammals that is not as widely found in other vertebrates. Second, studies on mice suggest that the maternal age effect that accelerates the incidence of Down ...

    journal_title：Experimental gerontology

    pub_type： 杂志文章,评审

    doi：10.1016/0531-5565(94)90009-4

    authors： Finch CE

    更新日期：1994-05-01 00:00:00

  • Age-related deterioration in trabecular bone mechanical properties at material level: nanoindentation study of the femoral neck in women by using AFM.

    abstract：:Despite general belief that the mechanical properties of bone material contribute to whole bone strength, it is still obscure what the age effects are on mechanical behavior of the bone material, particularly in the case of the femoral neck trabeculae. In this study, atomic force microscopy was used for imaging and me...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2011.11.011

    authors： Milovanovic P,Potocnik J,Djonic D,Nikolic S,Zivkovic V,Djuric M,Rakocevic Z

    更新日期：2012-02-01 00:00:00

  • Dietary restriction delays the secretion of senescence associated secretory phenotype by reducing DNA damage response in the process of renal aging.

    abstract：:Dietary restriction (DR) has multiple and essential effects in protecting against DNA damage in model organisms. Persistent DNA damage plays a central role in the process of aging. Senescence-associated secretory phenotype (SASP), as a product of cellular aging, can accelerate the process of cellular senescence as a f...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2017.09.005

    authors： Wang W,Cai G,Chen X

    更新日期：2018-07-01 00:00:00

  • Vitamin D receptor gene polymorphisms in Alzheimer's disease patients.

    abstract：THE AIM:The aim of this study was to determine whether polymorphisms of the VDR gene may increase the risk of Alzheimer disease (AD) development in Lower Silesian patients in comparison with other populations. MATERIAL AND METHODS:108 AD patients (aged 73.7±8.6) vs 77 healthy volunteers (aged 64.5±7.8) in the Lower Si...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2015.06.012

    authors： Łaczmański Ł,Jakubik M,Bednarek-Tupikowska G,Rymaszewska J,Słoka N,Lwow F

    更新日期：2015-09-01 00:00:00

  • Norepinephrine treatment and aging lead to systemic and intracellular oxidative stress in rats.

    abstract：:Reactive oxygen species (ROS) play important roles in cellular senescence and organismic aging. Furthermore, they have been implicated in some of the adverse effects of chronic stress due to elevated peripheral levels of catecholamines. Here, we applied three different techniques to individually compare the systemic a...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2007.08.003

    authors： Schraml E,Quan P,Stelzer I,Fuchs R,Skalicky M,Viidik A,Schauenstein K

    更新日期：2007-11-01 00:00:00

  • Role of the peripheral innate immune system in the development of Alzheimer's disease.

    abstract：:Alzheimer's disease is one of the most devastating neurodegenerative diseases. The exact cause of the disease is still not known although many scientists believe in the beta amyloid hypothesis which states that the accumulation of the amyloid peptide beta (Aβ) in brain is the initial cause which consequently leads to ...

    journal_title：Experimental gerontology

    pub_type： 杂志文章,评审

    doi：10.1016/j.exger.2017.12.019

    authors： Le Page A,Dupuis G,Frost EH,Larbi A,Pawelec G,Witkowski JM,Fulop T

    更新日期：2018-07-01 00:00:00

  • Association of increased autophagic inclusions labeled for beta-galactosidase with fibroblastic aging.

    abstract：:Replicative senescence appears after a finite number of cell divisions. After proliferation has ceased, senescent cells remain viable for long periods and metabolic modifications are observed such as lipofuscin accumulation. In order to understand this phenomenon, we examined the emergence of subcellular modifications...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/s0531-5565(03)00132-3

    authors： Gerland LM,Peyrol S,Lallemand C,Branche R,Magaud JP,Ffrench M

    更新日期：2003-08-01 00:00:00

  • Cardiorespiratory and cerebrovascular responses to head-up tilt II: influence of age, training status and acute exercise.

    abstract：:The purpose of this study was to examine the combined cardiorespiratory and cerebrovascular responses to head-up tilt (HUT) in young and older trained and untrained humans following moderate-duration exercise. Middle cerebral artery blood flow velocity (MCAv; transcranial Doppler ultrasound), blood pressure (BP; Finom...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2010.06.004

    authors： Murrell CJ,Cotter JD,George K,Shave R,Wilson L,Thomas K,Williams MJ,Ainslie PN

    更新日期：2011-01-01 00:00:00

  • Proteomic analysis of age dependent nitration of rat cardiac proteins by solution isoelectric focusing coupled to nanoHPLC tandem mass spectrometry.

    abstract：:Protein nitration occurs as a result of oxidative stress induced by reactive oxygen (ROS) and reactive nitrogen species (RNS). Therefore, protein nitration serves as a hallmark for protein oxidation in vivo. We have previously reported on age dependent protein nitration in cardiac tissue of Fisher 344 BN-F1 rats analy...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2007.03.005

    authors： Hong SJ,Gokulrangan G,Schöneich C

    更新日期：2007-07-01 00:00:00

  • Cognitive behavior and sensory function were significantly influenced by restoration of active ovarian function in postreproductive mice.

    abstract：:In mammals, the relationship between reproductive function and health has been particularly difficult to define. Previously, in old, postreproductive-aged mice, replacement of senescent ovaries with new ovaries from young, actively cycling mice increased life span. We hypothesized that the same factors that increased ...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2017.03.002

    authors： Parkinson KC,Peterson RL,Mason JB

    更新日期：2017-06-01 00:00:00

  • A cluster analysis study of acetyl-L-carnitine effect on NMDA receptors in aging.

    abstract：:Aging is associated with a reduction in the maximum density of n-methyl-d-aspartate (NMDA)-sensitive glutamate binding sites in the hippocampus of Fischer 344 rats. This study was designed to investigate the effect of acetyl-l-carnitine (ALCAR) on NMDA receptors in the old rat (24 months) after chronic or single-dose ...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/0531-5565(93)90042-c

    authors： Castorina M,Ambrosini AM,Giuliani A,Pacifici L,Ramacci MT,Angelucci L

    更新日期：1993-11-01 00:00:00

  • Costs and benefits of multifactorial falls prevention in nursing homes in the Netherlands.

    abstract：OBJECTIVES:To investigate whether the implementation of a multifactorial falls intervention in nursing homes is cost-beneficial and alleviates the professional workload. DESIGN:A comprehensive quantitative model was developed to calculate the impact of investments in multifactorial falls prevention in nursing homes in...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2020.111173

    authors： Panneman MJM,Sterke CS,Eilering MJ,Blatter BM,Polinder S,Van Beeck EF

    更新日期：2021-01-01 00:00:00

  • Sex as a confounding factor in the effects of ageing on rat lymph node t cell compartment.

    abstract：:The study examined the influence of sex on the alterations occurring with ageing in rat lymph node (LN) T cell compartment. In female and male rats the decrease in LN T cell counts was followed by a shift in CD4+/CD8+ T cell ratio towards CD8+ T cells, which was more prominent in males than in females. With ageing, in...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2020.111140

    authors： Nacka-Aleksić M,Stojić-Vukanić Z,Pilipović I,Blagojević V,Kotur-Stevuljević J,Leposavić G

    更新日期：2020-12-01 00:00:00

  • Effects of estrogen replacement therapy on the circadian rhythms of serum cortisol and body temperature in postmenopausal women.

    abstract：:Estrogen replacement therapy (ERT) seems to enhance longevity in women. Both gender and aging have been shown to influence the regulation of circadian rhythms, yet little is known about the effect of ERT on circadian regulation. The aim of this study was to determine the effects of ERT (oral conjugated estrogen: Prema...

    journal_title：Experimental gerontology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0531-5565(99)00044-3

    authors： Gudmundsson A,Goodman B,Lent S,Barczi S,Grace A,Boyle L,Ershler WB,Carnes M

    更新日期：1999-09-01 00:00:00