Pharmacological investigation of 'HIM-CHX': A herbal combination in the experimental muscle wasting condition.

abstract：:Fragility fractures due to osteoporosis and its most dreaded complication - hip fractures - are the cause of disability, high mortality and place a considerable burden on global health economics. Although much work has been done to accurately predict mortality and find risk factors for poor health outcome, little atte...

journal_title：Experimental gerontology

authors： Dovjak P,Heinze G,Rainer A,Sipos W,Pietschmann P

更新日期：2017-10-01 00:00:00

abstract：:In the present paper, we investigated whether the phenotype, the antigen-presenting capacity, and the migration of antigen-presenting cells (APCs), are affected by the aging process. APCs were obtained incubating peritoneal monocyte-macrophage cells with granulocyte-macrophage colony-stimulating factor (GM-CSF) (immat...

journal_title：Experimental gerontology

authors： Donnini A,Argentati K,Mancini R,Smorlesi A,Bartozzi B,Bernardini G,Provinciali M

更新日期：2002-08-01 00:00:00

abstract：:Serum lipid peroxide (LPO) in 72 healthy male subjects was studied using a newly developed assay method based on the reaction of LPO with methylene blue derivative (MCDP; 10-N-Methylcarbamoyl-3,7-dimethylamino-10 H-phenothiazine). This method is specific for lipid hydroperoxide and the relation is equimolar. The value...

journal_title：Experimental gerontology

authors： Tateishi T,Yoshimine N,Kuzuya F

更新日期：1987-01-01 00:00:00

abstract：:An age-related increase of DNA damage/mutation has been previously reported in human lymphocytes. The high copy number and mutation rate make the mtDNA genome an ideal candidate for assessing damage and to act as a potential biomarker of ageing. In the present study, two assays were developed to evaluate the level of ...

journal_title：Experimental gerontology

authors： Ross OA,Hyland P,Curran MD,McIlhatton BP,Wikby A,Johansson B,Tompa A,Pawelec G,Barnett CR,Middleton D,Barnett YA

更新日期：2002-01-01 00:00:00

abstract：:It has been often demonstrated that during senescence some neurons undergo atrophic changes while others add new processes and terminals. Because microtubules form a substantial component of the dendritic and axonal cytoskeleton, we have studied the amount of tubulin and acetylated alpha-tubulin in three young (6 mont...

journal_title：Experimental gerontology

authors： Fifkova E,Morales M

更新日期：1992-01-01 00:00:00

abstract：:The purpose of this study is to investigate possible influences of different stressors (saline injections, light deprivation and constant light regimen) and geroprotectors (Epitalon and melatonin) on survivals of female HER-2/neu transgenic mice. We propose a semi-parametric model of heterogeneous mortality (frailty m...

journal_title：Experimental gerontology

authors： Semenchenko GV,Anisimov VN,Yashin AI

更新日期：2004-10-01 00:00:00

abstract：:The purpose of this study was to examine the effect of a mentally fatiguing task on postural responses to unexpected backward perturbations in sixteen young and sixteen older women. Postural responses were characterized by center of pressure (COP) displacement, corrective COP peak velocity, and electromyography (EMG) ...

journal_title：Experimental gerontology

authors： Morris AJ,Christie AD

更新日期：2020-04-01 00:00:00

abstract：:Homeostenosis (i.e. decline in stress resistance and resilience with age) is a fundamental notion of the biogerontology and physiology of aging. Stressful situations typically challenge metabolic homeostasis and the capacity to recover from a stress-induced metabolic disorder might be particularly compromised in senes...

journal_title：Experimental gerontology

authors： Colinet H,Renault D

更新日期：2018-02-01 00:00:00

abstract：:Pioglitazone (Piog) activates peroxisome proliferator activated receptor-γ (PPARγ) and is widely used in clinic for the treatment of diabetes mellitus. PPARγ in various tissues has the essential regulatory role of multiple metabolic function, suggest that PPARγ signaling may contribute to aging processes. However, lit...

journal_title：Experimental gerontology

authors： Shen D,Li H,Zhou R,Liu MJ,Yu H,Wu DF

更新日期：2018-02-01 00:00:00

abstract：:To test if the adrenocortical axis of the rat loses sensitivity to negative feedback control during aging, we examined corticosterone secretion under basal, stressed and post-stress conditions in young and in aged Fisher male rats. We find no age-related change in the speed or magnitude of the stress response or in th...

journal_title：Experimental gerontology

authors： Sapolsky RM,Krey LC,McEwen BS

更新日期：1983-01-01 00:00:00

abstract：:The correlation between serum levels of pituitary and thyroid hormones and the activity of two antioxidant enzymes (AOE), catalase (CAT) and superoxide dismutase (SOD), in different immune and nonimmune organs of young and old rats was investigated. Serum levels of growth hormone (GH), prolactin (Prl), thyroid-stimula...

journal_title：Experimental gerontology

authors： Bolzán AD,Brown OA,Goya RG,Bianchi MS

更新日期：1995-03-01 00:00:00

abstract：:Threat-related changes in postural control and their associations with changes in emotional and cognitive states are influenced by postural threat experience, however, limited work has explored individuals' capacity to adapt threat-related responses over longer periods of threat exposure. This study examined the effec...

journal_title：Experimental gerontology

authors： Johnson KJ,Zaback M,Tokuno CD,Carpenter MG,Adkin AL

更新日期：2019-07-15 00:00:00

abstract：BACKGROUND:Critically ill intensive care patients are subjected to controlled mechanical ventilation (CMV) which has an important association in triggering the impaired muscle function and the consequent delayed weaning from the respirator. AIM:The main aim of this study was to measure the effects of age and CMV over ...

journal_title：Experimental gerontology

authors： Cacciani N,Ogilvie H,Larsson L

更新日期：2014-11-01 00:00:00

abstract：:Accumulation of altered proteins is the most common molecular symptom of ageing. Altered proteins are also associated with many age-related pathologies. Altered proteins are continuously produced but are normally selectively degraded by cellular proteases; their accumulation during ageing may be explained by either or...

journal_title：Experimental gerontology

authors： Hipkiss AR

更新日期：2006-05-01 00:00:00

abstract：:Every organism must adapt and respond appropriately to the source of nutrients available in its environment. Different mechanisms and pathways are involved in detecting the intracellular and extracellular levels of macronutrients including amino acids. Detection of amino acids in food sources is provided by taste cell...

journal_title：Experimental gerontology

authors： Lushchak O,Strilbytska OM,Yurkevych I,Vaiserman AM,Storey KB

更新日期：2019-01-01 00:00:00

abstract：:The gangliosides in human diploid fibroblasts--TIG-1, TIG-7, and IMR-90--were analysed at different cell densities at early and late passages to clarify the relationship between age and cell density dependent changes of the gangliosides. In early passages, the ganglioside concentrations increased with increase in cell...

journal_title：Experimental gerontology

authors： Ohsawa T

更新日期：1989-01-01 00:00:00

abstract：:Replicative senescence appears after a finite number of cell divisions. After proliferation has ceased, senescent cells remain viable for long periods and metabolic modifications are observed such as lipofuscin accumulation. In order to understand this phenomenon, we examined the emergence of subcellular modifications...

journal_title：Experimental gerontology

authors： Gerland LM,Peyrol S,Lallemand C,Branche R,Magaud JP,Ffrench M

更新日期：2003-08-01 00:00:00

abstract：:The leucine-rich repeat transmembrane 3 (LRRTM3) has been defined as a positional and functional candidate gene for Alzheimer's disease. Recently, four novel variants (rs16923760, rs1925608, rs1925609 and rs10997477) within LRRTM3 were reported to be associated with late-onset Alzheimer's disease (LOAD) in Caucasians....

journal_title：Experimental gerontology

authors： Wang J,Yu JT,Jiang T,Tan MS,Wang HF,Tan L,Hu N,Sun L,Zhang W,Tan L

更新日期：2014-04-01 00:00:00

abstract：INTRODUCTION:The ageing process can be influenced by different dietary patterns and dietary factors. AIM:To analyse the association of dietary factors, which include the Mediterranean diet adherence, the compliance with the "Sociedad Española de Nutrición Comunitaria" food portion recommendations, and the intake of di...

journal_title：Experimental gerontology

authors： Jurado-Fasoli L,Amaro-Gahete FJ,De-la-O A,Martinez-Tellez B,Ruiz JR,Gutiérrez Á,Castillo MJ

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:Right ventricular dysfunction (RVD), submassive pulmonary embolism (PE), elevated systolic pulmonary artery pressure (sPAP), elevated cardiac troponin I (cTnI) and old age are well-known risk factors for poor outcome in acute normotensive PE. The aim of this analysis was to calculate age cut-off values to ...

journal_title：Experimental gerontology

authors： Keller K,Beule J,Coldewey M,Geyer M,Balzer JO,Dippold W

更新日期：2015-09-01 00:00:00

abstract：:The alterations of the lipid composition and fluidity of liver plasma membranes as well as the activity of membrane-bound phospholipase A2 (EC 3.1.1.4) in male and female rats of different ages are investigated. An age-induced increase of the protein/phospholipid and cholesterol/phospholipid ratios is observed, as wel...

journal_title：Experimental gerontology

authors： Petkova DH,Momchilova AB,Koumanov KS

更新日期：1986-01-01 00:00:00

abstract：:A micromethod was used to study myelin from individual rat optic nerves as a function of age. Protein and galactolipid content as well as 2',3'-cyclic nucleotide phosphohydrolase (CNPase) activity at ages 2, 4, 22, and 28 months were determined. Protein content increased significantly at 22 months and decreased at adv...

journal_title：Experimental gerontology

authors： Jacks AS,Richardson AR,Jones MA

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Sarcopenic obesity is a combination of both sarcopenia and obesity, which potentiate each other and maximize the negative influences of each, such as physical disability, morbidity, or even mortality. OBJECTIVES:To describe the criteria used to identify people with sarcopenic obesity and the components of t...

journal_title：Experimental gerontology

authors： Yin YH,Liu JYW,Välimäki M

更新日期：2020-07-01 00:00:00

abstract：:The role of the glucocorticoid receptor (GR) in senescence was studied in rats of increasing age. Statistically significant changes in the number of GRs from rat liver were detected, whereas the affinity for the ligand triamcinolone acetonide (TA) did not change with increasing age, and was in the range of 1-2 nM. In ...

journal_title：Experimental gerontology

authors： Djordjevic-Markovic R,Radic O,Jelic V,Radojcic M,Rapic-Otrin V,Ruzdijic S,Krstic-Demonacos M,Kanazir S,Kanazir D

更新日期：1999-12-01 00:00:00

abstract：:The effect of DL-alpha-lipoic acid on lipid peroxidation and antioxidant enzymes were evaluated in various brain regions of young and aged rats. Lipoate contents of discrete brain regions were also measured. In aged rats, the activities of superoxide dismutase, glutathione peroxidase, glutathione reductase and glucose...

journal_title：Experimental gerontology

authors： Arivazhagan P,Shila S,Kumaran S,Panneerselvam C

更新日期：2002-06-01 00:00:00

abstract：:Histological surveys of the hearts of guppies Poecilia reticulatus throughout their lifespan showed no aging changes until the fish were three years old. In younger fishes the hearts were healthy, even in three individuals with "wasting" disease, where there was considerable loss of muscle throughout the body. There w...

journal_title：Experimental gerontology

authors： Woodhead AD

更新日期：1984-01-01 00:00:00

abstract：INTRODUCTION:Age-related decreases in cerebral blood flow (CBF) may lead to cognitive decline, while physical activity (PA) can maintain CBF and cognition in aging. The intensity of PA needed to affect CBF in aging, and the independent effects of sedentary time on CBF are currently unknown. Moreover, research conducted...

journal_title：Experimental gerontology

authors： Zlatar ZZ,Hays CC,Mestre Z,Campbell LM,Meloy MJ,Bangen KJ,Liu TT,Kerr J,Wierenga CE

更新日期：2019-10-01 00:00:00

abstract：:The visual appearance of humans derives predominantly from their skin and hair color. The phylogenetically ancient biochemical [corrected] pathway underling this phenomenon is called melanogenesis and results in the production of melanin pigments in neural crest-derived melanocytes, followed by its transfer to epithel...

journal_title：Experimental gerontology

authors： Tobin DJ,Paus R

更新日期：2001-01-01 00:00:00

abstract：:Calorie restriction (CR) may affect glucose tolerance via modulation of the insulin action in skeletal muscle. The present study investigated the effect of CR initiated at middle age in rats bearing glucose intolerance, in comparison with CR at a younger age. Male F344 rats at 2.5 and 18months (mo) of age were fed ad ...

journal_title：Experimental gerontology

authors： Park S,Komatsu T,Hayashi H,Yamaza H,Chiba T,Higami Y,Kuramoto K,Shimokawa I

更新日期：2006-09-01 00:00:00

abstract：:A non-enzymatic reaction between ketones or aldehydes and the amino groups of proteins, lipids and nucleic acids contributes to the aging of macromolecules and to the development and progression of various age-related disorders such as vascular complications of diabetes, Alzheimer's disease, cancer growth and metastas...

journal_title：Experimental gerontology

authors： Yamagishi S

更新日期：2011-04-01 00:00:00