Abstract:
:Studying the changes of serum N-glycome during mouse aging is beneficial to explore the molecular basis behind the alterations reported in human. However, such studies remainscarce and lack some information such as sialylation due to the method limitation. Here, we introduced Bionic Glycome method to quantify the serum N-glycome changes during C57BL/6 mouse aging (from the pubertal period to the old age stage). This technique enabled reliable and comprehensive quantitation of the expression level changes of more than 20 N-glycans in mouse serum at 12 time points in both genders for the first time, involving the analysis of sialic acid and its different linkages. The results demonstrated that the expression level of total glycans increased from middle age to old age. Interestingly, sex-specific N-glycome profiles and alterations were observed. Female mice showed higher level of serum fucosylation and lower level of serum afucosylation than male mice (fucosylation: p < 1.0E-6; afucosylation: p < 1.0E-6). Obviously, higher increase of serum fucosylation level was found in female mice than in male mice from middle age to old age. In addition, the opposite alterations of the afucosylated glycans with α2,3-linked sialic acid and those only with α2,6-linked sialic acid were observed at old age in male mice. These findings suggested that N-glycome could be a valuable target for investigating aging and possible contributors to aging.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Han J,Pan Y,Qin W,Gu Y,Xu X,Zhao R,Sha J,Zhang R,Gu J,Ren Sdoi
10.1016/j.exger.2020.111098subject
Has Abstractpub_date
2020-11-01 00:00:00pages
111098eissn
0531-5565issn
1873-6815pii
S0531-5565(20)30446-0journal_volume
141pub_type
杂志文章abstract::We suggest that the processes that protect the turtle brain against anoxia and subsequent reoxygenation might also contribute to turtle longevity since many of them are linked to age related neurodegeneration. In the turtle the mechanisms for conserving ion channel function are particularly robust. The anoxic turtle b...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(03)00111-6
更新日期:2003-07-01 00:00:00
abstract::Connexin 43 (Cx43) is the constitutive protein for the formation of cardiac gap junctions and therefore essential for cell-cell coupling and normal cardiac function. Apart from its localization at the sarcolemma, Cx43 is present in the inner mitochondrial membrane. Cx43 is involved in cardiomyocyte free oxygen radical...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2006.01.011
更新日期:2006-05-01 00:00:00
abstract::Natural killer (NK) cells play an important role in controlling several viral diseases. Our previous studies demonstrated an age-dependent susceptibility to mousepox due to defective NK cell responses and trafficking. However, the mechanisms that underlie the age-related impairment in NK cell migration have yet to be ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.06.021
更新日期:2017-10-01 00:00:00
abstract::Effects of glucagon and epinephrine stimulation on urea synthesis from lactate, pyruvate, NH4Cl, and ornithine in isolated rat hepatocytes from young and old rats were compared. It was found that the production of urea from those substrates was almost the same in both age groups. The concentrations of hormones that ca...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(85)90052-x
更新日期:1985-01-01 00:00:00
abstract::Acute illness requiring hospitalization is a sentinel event leading to functional decline and frequently, long-term disability in older adults. Although functional decline has become a key outcome during and after hospitalization, there is currently no gold standard for measuring functional impairment. The purpose of ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2019.110631
更新日期:2019-09-01 00:00:00
abstract::Aging is associated with a reduction in the maximum density of n-methyl-d-aspartate (NMDA)-sensitive glutamate binding sites in the hippocampus of Fischer 344 rats. This study was designed to investigate the effect of acetyl-l-carnitine (ALCAR) on NMDA receptors in the old rat (24 months) after chronic or single-dose ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(93)90042-c
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Homocysteine (Hcy) high levels are associated with fractures, bone resorption and an early onset of osteoporosis in elderly persons; a relationship between Hcy and bone formation has also been suggested but is still controversial. Frailty, an independent predictor of fractures and decreased bone mineral dens...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2018.04.019
更新日期:2018-07-15 00:00:00
abstract::The aim of this study was to compare the functional and structural changes in similarly identified neurons of the small parietal ganglion in 56 molluscs (Lymnaea stagnalis) of two age groups: adult (10-12 months) and old (20-22 months). No age changes were found in the values of membrane potential, resistance of the n...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(95)00008-5
更新日期:1995-09-01 00:00:00
abstract::Primary cultures of hepatocytes are widely used to investigate liver function, but this technology has not been exploited fully in the study of ageing and caloric restriction (CR). Hepatocytes were isolated from adult and aged, fully fed, and calorie restricted male Sprague-Dawley rats and their viability and biochemi...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(00)00101-7
更新日期:2000-08-01 00:00:00
abstract::Plasma and pituitary concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin (Prl) were determined by radioimmunoassay in young (2-4 months-old) and aged CD-1 (14-18 months-old) and C57BL/6 (16-22 months-old) mice one month after ovariectomy. In young, ovariectomized mice, plasma ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(82)80005-3
更新日期:1982-01-01 00:00:00
abstract::Senescence accelerated mice (SAM) are susceptible to developing vascular dysfunction and remodeling. Food intake and type of diet have also been identified as determining factors in vascular remodeling. However, the interplay between senescence and diet in vascular remodeling is largely unknown. We aimed to analyze st...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.03.004
更新日期:2014-07-01 00:00:00
abstract::Raw bioelectrical impedance analysis (BIA) data [resistance (R); reactance (Xc)] through bioelectrical impedance vector analysis (BIVA) and phase angle (PhA) have been used to evaluate cellular function and hydration status. The purpose of this investigation was to examine the effects of resistance training (RT) on cl...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2015.12.002
更新日期:2016-02-01 00:00:00
abstract::Progressive neuronal deterioration accompanied by sensory functions decline is typically observed during aging. On the other hand, structural or functional alterations of specific sensory neurons extend lifespan in the nematode Caenorhabditis elegans. Hormesis is a phenomenon by which the body benefits from moderate s...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.03.026
更新日期:2014-08-01 00:00:00
abstract::Mitochondria play a critical role in the life of the cell as they control their metabolic rate, energy production and cell death. Mitochondria have long been appreciated as causative to aging. The age-associated respiratory chain deficiency is typically unevenly distributed and affects only a subset of cells in variou...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2008.05.006
更新日期:2009-01-01 00:00:00
abstract::The purposes of this study were to examine the age-related differences in absolute and normalized torque-time parameters in five distinct groups across the adult lifespan, and the relationship between rapid strength and limb acceleration capacities across the lifespan. One-hundred and thirty-six healthy men were categ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2019.110819
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:We explored the male-female health-survival paradox in the context of health expectancy (HE) at age 65 and thereafter, using three different morbidity measures and different severity cut-offs with and without adjustments for the share of nursing home residents. METHODS:HE at ages 65, 70, 75, 80, and 85 was ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.111196
更新日期:2021-03-01 00:00:00
abstract::Pioglitazone (Piog) activates peroxisome proliferator activated receptor-γ (PPARγ) and is widely used in clinic for the treatment of diabetes mellitus. PPARγ in various tissues has the essential regulatory role of multiple metabolic function, suggest that PPARγ signaling may contribute to aging processes. However, lit...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.12.002
更新日期:2018-02-01 00:00:00
abstract::An age-related increase of DNA damage/mutation has been previously reported in human lymphocytes. The high copy number and mutation rate make the mtDNA genome an ideal candidate for assessing damage and to act as a potential biomarker of ageing. In the present study, two assays were developed to evaluate the level of ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(01)00200-5
更新日期:2002-01-01 00:00:00
abstract::The adult blowfly, Phormia regina, reveals a substantial homeostatic capability when examined for its ability to regulate externally administered additions to its blood sugar. As well, results of experiments done at intervals throughout the entire adult life of the fly show that there is no decrease over time in the e...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(86)90058-6
更新日期:1986-01-01 00:00:00
abstract::To explore the relationship between age-related hearing loss (presbycusis) and synaptic degeneration in the hippocampal CA3 region of C57BL/6J mice, we investigated both cognitive performance and synaptic changes within the hippocampus of C57BL/6J mice from three age groups of 6-8, 24-26, and 42-44 weeks; CBA/CaJ mice...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2011.04.007
更新日期:2011-09-01 00:00:00
abstract:PURPOSE:Aging changes the balance of sex hormones and causes endothelial dysfunction in the penis, both of which are important determinants of erectile dysfunction (ED). The purpose of this study was to evaluate whether exercise training could protect against erectile dysfunction by increasing serum testosterone and pe...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2018.04.003
更新日期:2018-07-15 00:00:00
abstract::We have developed a simian virus 40 (SV40) T-antigen immortalized human cell line, 1MR90-D305.2H4 (IDH4), in which the expression of T-antigen is controlled by the mouse mammary tumor virus (MMTV) promoter and thus regulated by steroids such as dexamethasone. Studies on the regulation of proliferation by T-antigen led...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(92)90003-i
更新日期:1992-09-01 00:00:00
abstract::The purpose of this study was to examine the combined cardiorespiratory and cerebrovascular responses to head-up tilt (HUT) in young and older trained and untrained humans following moderate-duration exercise. Middle cerebral artery blood flow velocity (MCAv; transcranial Doppler ultrasound), blood pressure (BP; Finom...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2010.06.004
更新日期:2011-01-01 00:00:00
abstract::Cellular aging plays a role in longevity and senescence, and has been implicated in medical and psychiatric conditions, including heart disease, cancer, major depression and posttraumatic stress disorder. Telomere shortening and mitochondrial dysfunction are thought to be central to the cellular aging process. The pre...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2015.04.002
更新日期:2015-06-01 00:00:00
abstract::Apoptosis plays an important role in atrophy and sarcopenia in skeletal muscle. Recent evidence suggests that insufficient heat shock proteins (HSPs) may contribute to apoptosis and muscle wasting. In addition, long-term caloric restriction (CR) and lifelong wheel running exercise (WR) with CR provide significant prot...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2015.06.007
更新日期:2015-09-01 00:00:00
abstract::Accumulating evidence from diverse experiments, including heterochronic parabiosis-the surgical joining of two animals of different ages-has highlighted the importance of systemic factors in the progressive functional decline of various organs and tissues during aging. The major metabolic pathway of tryptophan, an ess...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2019.110793
更新日期:2020-02-01 00:00:00
abstract::Mitochondria isolated from the livers of old rats (26-30 months) were found to incorporate 41% less leucine into mitochondrial proteins as compared to those from young rats (2-3 months). The initial rates of incorporation of label were 145 cpm/mg/min for the "old" animals, and 320 cpm/mg/min for the young animal. No d...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(82)80004-1
更新日期:1982-01-01 00:00:00
abstract::Increased lifespan can be associated with greater resistance to many different stressors, most notably thermal stress. Such hormetic effects have also been found in C. elegans where short-term exposure to heat lengthens the lifespan. Genetic investigations have been carried out using mutation perturbations in a single...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2012.05.005
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Resistance exercise training (RET) has proven effective at reducing the risk of chronic disease in older populations, and it appears to regulate redox homeostasis. AIMS:To determine the effects of RET on redox homeostasis in older people. STUDY DESIGN:A systematic review and meta-analysis of randomized cli...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2020.111012
更新日期:2020-09-01 00:00:00
abstract::The age-dependent modifications of both basal and lymphokine-induced natural killer (NK) activity were analyzed in Balb/c inbred mice by measuring either the percentage of specific lytic activity in a 51 Cr release assay or the percentage of cells capable of binding the YAC-1 target cells. The basal lytic activity of ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(89)90014-4
更新日期:1989-01-01 00:00:00