Adherence to the Mediterranean diet, dietary factors, and S-Klotho plasma levels in sedentary middle-aged adults.

abstract：:Brain aging, Alzheimer disease and stroke share common elements of deficits in calcium regulation, declines in mitochondrial function, increases in generation of reactive oxygen species (ROS), accumulated damage from ROS and immune system dysfunction. The problem is to distinguish less significant side reactions, such...

journal_title：Experimental gerontology

authors： Brewer GJ

更新日期：2000-12-01 00:00:00

abstract：:Age-related changes of immune functions have been extensively investigated in both humans and animal models; nevertheless, the literature on potential alterations of dendritic cells, potent antigen presenting cells responsible for initiating immune responses, with aging is very scarce. We studied the immuno-phenotype ...

journal_title：Experimental gerontology

authors： Pietschmann P,Hahn P,Kudlacek S,Thomas R,Peterlik M

更新日期：2000-03-01 00:00:00

abstract：:Ageing is a complex process that in muscle in usually associated with a decrease in mass, strength, and velocity of contraction. One of the most striking effects of ageing on muscle is known as sarcopenia, a process that is the result of many cellular changes, such as a reduction in the number of motor units coupled w...

journal_title：Experimental gerontology

authors： Fulle S,Protasi F,Di Tano G,Pietrangelo T,Beltramin A,Boncompagni S,Vecchiet L,Fanò G

更新日期：2004-01-01 00:00:00

abstract：:The interrelationship between muscle strength, motor unit (MU) number, and age is poorly understood, and in this study we sought to determine whether age-related differences in muscle strength are moderated by estimates of functioning MU number and size. Eighteen older adults (OA; 67 ± 1.20 years) and 24 young adults ...

journal_title：Experimental gerontology

authors： Kaya RD,Nakazawa M,Hoffman RL,Clark BC

更新日期：2013-09-01 00:00:00

abstract：:Aging is associated with altered immune responses, particularly with a diminished CD8 T cell response. Although both intrinsic and extrinsic factors are hypothesized to impact this decreased T cell response, the direct evidence of an intrinsic deficiency in virus-specific CD8 T cells is limited. In this study, a TCR t...

journal_title：Experimental gerontology

authors： Jiang J,Fisher EM,Murasko DM

更新日期：2013-06-01 00:00:00

abstract：:The correlation between serum levels of pituitary and thyroid hormones and the activity of two antioxidant enzymes (AOE), catalase (CAT) and superoxide dismutase (SOD), in different immune and nonimmune organs of young and old rats was investigated. Serum levels of growth hormone (GH), prolactin (Prl), thyroid-stimula...

journal_title：Experimental gerontology

authors： Bolzán AD,Brown OA,Goya RG,Bianchi MS

更新日期：1995-03-01 00:00:00

abstract：:Since the reproducible production of microscope objectives was enabled by the lens calculations of Ernst Abbe in 1872, various attempts have been made to further increase the resolution of light microscopes. Apart from the improvements on the optical side, especially the introduction of fluorescence methods, the use o...

journal_title：Experimental gerontology

authors： Malkusch W,Bauch H,Schäfer L

更新日期：2001-07-01 00:00:00

abstract：:The Senescence-Accelerated Mouse (SAM) strains are unique and appropriate models for genetic studies on aging because the SAMP strains have an "accelerated senescence" phenotype for which the SAMR strains are controls, and each SAMP strain has a strain-specific age-associated disorder. Furthermore, because they have g...

journal_title：Experimental gerontology

authors： Higuchi K

更新日期：1997-01-01 00:00:00

abstract：:Lipids constitute a significant group of biological metabolites and the building blocks of all cell membranes. The abundance and stoichiometries of different lipid species are known to vary across the lifespan and metabolic state, yet the functional effects of these changes have been challenging to understand. Here we...

journal_title：Experimental gerontology

authors： Skowronska-Krawczyk D,Budin I

更新日期：2020-03-01 00:00:00

abstract：:Raw bioelectrical impedance analysis (BIA) data [resistance (R); reactance (Xc)] through bioelectrical impedance vector analysis (BIVA) and phase angle (PhA) have been used to evaluate cellular function and hydration status. The purpose of this investigation was to examine the effects of resistance training (RT) on cl...

journal_title：Experimental gerontology

authors： Fukuda DH,Stout JR,Moon JR,Smith-Ryan AE,Kendall KL,Hoffman JR

更新日期：2016-02-01 00:00:00

abstract：:The effect of 3-(4-pyridyl)-1,2,4-thiotriazolyl 5-mercaptoacetic acid kalium salt (Rumosol) and 3-(4-pyridyl)-1,2,4-thiotriazolyl 5-mercaptoacetic acid morpholinium salt (drug 2) on the concentration of Schiff base in myocardium of adult (10-12 months) and old (22-25 months) Wistar rats during immobilized stress were ...

journal_title：Experimental gerontology

authors： Davydov VV,Shvets VN

更新日期：2002-04-01 00:00:00

abstract：:The maximal lifespan (MLS) of mammals is inversely correlated with the peroxidation index, a measure of the proportion and level of unsaturation of polyunsaturated fatty acids (PUFA) in membranes. This relationship is likely related to the fact that PUFA are highly susceptible to damage by peroxidation. Previous compa...

journal_title：Experimental gerontology

authors： Cortie CH,Hulbert AJ,Hancock SE,Mitchell TW,McAndrew D,Else PL

更新日期：2015-10-01 00:00:00

abstract：:Degeneration of tongue muscles with aging may contribute to swallowing deficits observed in elderly people. However, the capacity for tongue muscle stem cells (SCs) to regenerate and repair the aged tongue and improve tongue strength following tongue exercise (a current clinical treatment) has never been examined. We ...

journal_title：Experimental gerontology

authors： Kletzien H,Kelm-Nelson CA,Wang S,Suzuki M,Connor NP

更新日期：2020-12-01 00:00:00

abstract：:Telomerase plays an important role in cellular proliferation capacity and survival under conditions of stress. A large part of this protective function is due to telomere capping and maintenance. Thus it contributes to cellular immortality in stem cells and cancer. Recently, evidence has accumulated that telomerase ca...

journal_title：Experimental gerontology

authors： Saretzki G

更新日期：2009-08-01 00:00:00

abstract：:Cardiovascular disease (CVD) is an important public health problem affecting especially the elderly. Over the past 20years, an increasing number of studies have examined its underlying pathophysiological mechanisms and new therapies are continually being discovered. However, despite considerable progress in CVD manage...

journal_title：Experimental gerontology

authors： Recchioni R,Marcheselli F,Antonicelli R,Mensà E,Lazzarini R,Procopio AD,Olivieri F

更新日期：2017-12-15 00:00:00

abstract：:Protein nitration occurs as a result of oxidative stress induced by reactive oxygen (ROS) and reactive nitrogen species (RNS). Therefore, protein nitration serves as a hallmark for protein oxidation in vivo. We have previously reported on age dependent protein nitration in cardiac tissue of Fisher 344 BN-F1 rats analy...

journal_title：Experimental gerontology

authors： Hong SJ,Gokulrangan G,Schöneich C

更新日期：2007-07-01 00:00:00

abstract：:Although galanin has been shown to increase GLUT4 expression in the cardiac muscle of rats, there is no literature available about the effect of GalR1 on GLUT4 expression in the cardiac muscle of type 2 diabetic rats. The aim of this study was to determine whether intracerebroventricular injection of GalR1 agonist M61...

journal_title：Experimental gerontology

authors： Fang P,Shi M,Zhu Y,Zhang Z,Bo P

更新日期：2015-05-01 00:00:00

abstract：:The dependent elderly are widely considered to be at higher risk of nutritional problems. Suboptimal micronutrient intake might put the elderly, especially those living in nursing homes, at high risk of morbidity. So far, no public authority, except for the Israel Ministry of Health, has issued particular recommendati...

journal_title：Experimental gerontology

authors： Tal S,Stern F,Polyak Z,Ichelzon I,Dror Y

更新日期：2016-11-01 00:00:00

abstract：:Given the increased concerns about the degenerative decline in the physical performance of the elderly, there is a need for developing effective strategies to suppress the age-related loss of skeletal muscle mass and functional capacity through a lifestyle intervention. This randomized controlled trial examined whethe...

journal_title：Experimental gerontology

authors： Lim NJ,Shin JH,Kim HJ,Lim Y,Kim JY,Lee WJ,Han SJ,Kwon O

更新日期：2017-01-01 00:00:00

abstract：:It is well established that during early life the thymus gland and the neuroendocrine system influence each other's maturation. Furthermore, there is a growing body of evidence indicating that the immune and neuroendocrine systems also function as a bidirectional network during adult life. In order to assess possible ...

journal_title：Experimental gerontology

authors： Goya RG,Naylor PH,Goldstein AL,Meites J

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:Senescent patients exhibit an elevated perioperative risk for cardiac dysfunction, hemodynamic depression and subsequent cardiac death compared to young patients. Despite the fact that a growing proportion of cardiac surgery patients are octogenarians, cardioplegic regimes remain comparable across patients of...

journal_title：Experimental gerontology

authors： Böning A,Rohrbach S,Kohlhepp L,Heep M,Hagmüller S,Niemann B,Mühlfeld C

更新日期：2015-07-01 00:00:00

abstract：:Aging is associated with changes in lymphocyte subsets and unexplained HLA-DR upregulation on T-lymphocytes. We further investigated this activation, by measuring early (CD69), middle (CD25), and late (HLA-DR) T-lymphocyte activation markers on CD3+ lymphocytes, across subjects (20-100 years) together with serum tumor...

journal_title：Experimental gerontology

authors： Rea IM,McNerlan SE,Alexander HD

更新日期：1999-01-01 00:00:00

abstract：:The CG9940 gene, which encodes the NAD(+) synthase protein in Drosophila, is conserved in human, zebra fish, and mosquito. NAD(+) synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic a...

journal_title：Experimental gerontology

authors： Wen DT,Zheng L,Ni L,Wang H,Feng Y,Zhang M

更新日期：2016-10-01 00:00:00

abstract：:Senescence, a deteriorative process that increases the probability of death of an organism with increasing chronological age, has been found in all metazoans where careful studies have been carried out. There has been much controversy, however, about the potential immortality of hydra, a solitary freshwater member of ...

journal_title：Experimental gerontology

authors： Martínez DE

更新日期：1998-05-01 00:00:00

abstract：:Reductions in physical performance, cognitive impairment (CI) and decline (CD), are common in older age, but few prospective cohort studies have considered the relationship between these domains. In this study we investigated whether reduced physical performance and low handgrip/lower limbs strength, could predict a h...

journal_title：Experimental gerontology

authors： Veronese N,Stubbs B,Trevisan C,Bolzetta F,De Rui M,Solmi M,Sartori L,Musacchio E,Zambon S,Perissinotto E,Crepaldi G,Manzato E,Sergi G

更新日期：2016-08-01 00:00:00

abstract：:Neuroinflammation may play a role in the pathogenesis of Parkinson's disease (PD). The present study questioned whether this neuroinflammatory response differs between the olfactory bulb, as an early affected region and the nigrostriatal system. Indeed, increased microgliosis was shown in post-mortem olfactory bulb of...

journal_title：Experimental gerontology

authors： Vroon A,Drukarch B,Bol JG,Cras P,Brevé JJ,Allan SM,Relton JK,Hoogland PV,Van Dam AM

更新日期：2007-08-01 00:00:00

abstract：:Diseases of the elderly, including neurodegenerative and cardiovascular disorders and cancer, may develop through the accumulation of "hits" composed of genetic and epigenetic risk factors. The "iceberg" buildup of these hits over time may exceed the tolerance threshold of a particular tissue, thus precipitating disea...

journal_title：Experimental gerontology

authors： Wang E

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Homocysteine (Hcy) high levels are associated with fractures, bone resorption and an early onset of osteoporosis in elderly persons; a relationship between Hcy and bone formation has also been suggested but is still controversial. Frailty, an independent predictor of fractures and decreased bone mineral dens...

journal_title：Experimental gerontology

authors： Álvarez-Sánchez N,Álvarez-Ríos AI,Guerrero JM,García-García FJ,Rodríguez-Mañas L,Cruz-Chamorro I,Lardone PJ,Carrillo-Vico A

更新日期：2018-07-15 00:00:00

abstract：:We suggest that the processes that protect the turtle brain against anoxia and subsequent reoxygenation might also contribute to turtle longevity since many of them are linked to age related neurodegeneration. In the turtle the mechanisms for conserving ion channel function are particularly robust. The anoxic turtle b...

journal_title：Experimental gerontology

authors： Lutz PL,Prentice HM,Milton SL

更新日期：2003-07-01 00:00:00

abstract：:Estrogen replacement therapy (ERT) seems to enhance longevity in women. Both gender and aging have been shown to influence the regulation of circadian rhythms, yet little is known about the effect of ERT on circadian regulation. The aim of this study was to determine the effects of ERT (oral conjugated estrogen: Prema...

journal_title：Experimental gerontology

authors： Gudmundsson A,Goodman B,Lent S,Barczi S,Grace A,Boyle L,Ershler WB,Carnes M

更新日期：1999-09-01 00:00:00