Abstract：
:The dependent elderly are widely considered to be at higher risk of nutritional problems. Suboptimal micronutrient intake might put the elderly, especially those living in nursing homes, at high risk of morbidity. So far, no public authority, except for the Israel Ministry of Health, has issued particular recommendations for micronutrient supplementation for the elderly. We hypothesized that moderate 'multivitamin' supplementation could improve the vitamin status of the dependent elderly. The study took place in two nursing homes and included 144 dependent elderly (males/females, 35/109). Demographic and clinical data as well as routine blood tests were retrieved from the patient electronic medical records. After a two-year daily 'multivitamin' supplementation, containing 120μg of folic acid, there was a small and non-significant increase of 12% in serum folate; the same 'multivitamin' preparatory, containing 2.4μg of vitamin B12, significantly increased serum vitamin B12 by 8%. Three models of evaluation clearly showed the effect of a two- year vitamin supplementation: 1. The number of subjects with the lowest baseline concentration range, decreased, with moderate concentration, increased, with no difference at the higher concentrations; 2. Above each vitamin concentration, the number of subjects was higher than at baseline; 3. The two vitamins at the two lower concentration tertiles increased, and at the highest tertile, folate was not affected, whereas vitamin B12 decreased. Therefore, very moderate 'multivitamin' supplementation, as practiced in our study, has a high probability of improving vulnerable old population health status without causing any adverse effects to others.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Tal S,Stern F,Polyak Z,Ichelzon I,Dror Ydoi
10.1016/j.exger.2016.09.009subject
Has Abstractpub_date
2016-11-01 00:00:00pages
101-106eissn
0531-5565issn
1873-6815pii
S0531-5565(16)30335-7journal_volume
84pub_type
杂志文章abstract：:We have isolated a senescence-specific clone (pSEN) from a cDNA library constructed from late passage WI-38 human diploid fibroblast that accounts for approximately 1% of the recombinants. Nucleotide sequence analysis of the partial cDNA clone has led to the identification of pSEN as elongation factor I alpha. Norther...
journal_title：Experimental gerontology
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doi：10.1016/0531-5565(89)90056-9
更新日期：1989-01-01 00:00:00
abstract：:Aging is associated with a decline in immune functions. Among them, T-cell activation is altered at several points of the signaling cascade following TCR engagement. Recent findings suggest that lipid rafts act as a platform in the initiation of T-cell activation. We have previously demonstrated that cholesterol conte...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2003.10.031
更新日期：2004-04-01 00:00:00
abstract：:Aging is the major risk factor for numerous brain diseases. This is especially true for Alzheimer's disease (AD), a peculiar neurodegenerative disorder in that it results from the synergy of two simultaneous but distinct degenerating processes: A beta and tau pathologies. For AD, and for most neurodegenerative disorde...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2003.09.010
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abstract：:Ascorbic acid decreases from age-group I to II in Kidney, skeletal muscle, and increases in the Pancreas of female. There is no significant change in the Pancreas of male toad. There is an increase in the ascorbic acid content from age group II to III except in the Pancreas of females, where there is a decline of the ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(84)90011-1
更新日期：1984-01-01 00:00:00
abstract：:Age-associated thymic involution manifests its effects in a variety of ways that are related to a loss of T cell function. These include the appearance of a non-functional subset of T cells that increase in representation with age. Moreover there is a loss of T cell proliferative ability, a decline in the synthesis an...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/0531-5565(93)90058-l
更新日期：1993-07-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.04.003
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(02)00020-7
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pub_type： 杂志文章
doi：10.1016/0531-5565(92)90056-6
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doi：10.1016/j.exger.2020.111011
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(02)00202-4
更新日期：2003-03-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2005.12.004
更新日期：2006-03-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00101-7
更新日期：2000-08-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2005.04.007
更新日期：2005-07-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(85)90052-x
更新日期：1985-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(95)02027-6
更新日期：1996-05-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2014.12.003
更新日期：2015-08-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111175
更新日期：2021-02-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.exger.2015.03.011
更新日期：2015-06-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(02)00015-3
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journal_title：Experimental gerontology
pub_type： 杂志文章
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/0531-5565(92)90012-o
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.07.015
更新日期：2013-11-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.12.001
更新日期：2010-03-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.110663
更新日期：2019-10-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.08.007
更新日期：2004-10-01 00:00:00
abstract：BACKGROUND:Inflammation plays a pivotal role in amyloid plaque progression thereby contributing to Alzheimer's disease-related neurodegeneration. We hypothesized that patients with Alzheimer's disease have an innate pro-inflammatory phenotype, as compared to control subjects without dementia. METHODS:Patients with a d...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00176-5
更新日期：2001-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(86)90017-3
更新日期：1986-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111098
更新日期：2020-11-01 00:00:00
abstract：:Given the increased concerns about the degenerative decline in the physical performance of the elderly, there is a need for developing effective strategies to suppress the age-related loss of skeletal muscle mass and functional capacity through a lifestyle intervention. This randomized controlled trial examined whethe...
journal_title：Experimental gerontology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.exger.2016.11.003
更新日期：2017-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：2008-03-01 00:00:00
