Abstract：
:Neuroinflammation may play a role in the pathogenesis of Parkinson's disease (PD). The present study questioned whether this neuroinflammatory response differs between the olfactory bulb, as an early affected region and the nigrostriatal system. Indeed, increased microgliosis was shown in post-mortem olfactory bulb of PD patients. Also in olfactory bulb of MPTP-treated mice, microgliosis and increased expression of IL-1alpha, IL-1beta and IL-1ra mRNA was observed early after treatment. These observations implicate that neuroinflammation is not restricted to the nigrostriatal system. MPTP-induced microgliosis in striatum and olfactory bulb was reduced in IL-1alpha/beta knockout mice, indicating that IL-1 affects microglia activation. Importantly, MPTP induced differential regulation of IL-1 receptors. mRNA levels of IL-1RI and, to a lesser extent, IL-1RII were increased in striatum. Interestingly, in the olfactory bulb only IL-1RII mRNA was enhanced. We suggest that differential regulation of IL-1 signaling can serve as an important mechanism to modulate neuroinflammatory activity after MPTP treatment and possibly during PD.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Vroon A,Drukarch B,Bol JG,Cras P,Brevé JJ,Allan SM,Relton JK,Hoogland PV,Van Dam AMdoi
10.1016/j.exger.2007.04.010subject
Has Abstractpub_date
2007-08-01 00:00:00pages
762-71issue
8eissn
0531-5565issn
1873-6815pii
S0531-5565(07)00084-8journal_volume
42pub_type
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journal_title：Experimental gerontology
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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doi：10.1016/j.exger.2012.05.005
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
pub_type： 杂志文章
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journal_title：Experimental gerontology
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