Abstract:
:Age-associated thymic involution manifests its effects in a variety of ways that are related to a loss of T cell function. These include the appearance of a non-functional subset of T cells that increase in representation with age. Moreover there is a loss of T cell proliferative ability, a decline in the synthesis and release of interleukin-2 (IL-2), a decline in the ability of the T cell to express the IL-2 receptor, and a loss of control activity. This loss of control is demonstrated by the age-related appearance of autoantibodies and an increase in the elaboration of inflammatory cytokines such as TNF, IFN, IL-6, and TGF. A major part of the basis for the loss of T cell function is an inability of the T cell to respond to activation signals that are transmitted through the membrane binding of specific stimulatory signals. Transduction events, differentiation signals, and a loss of control mechanisms are all parts of a complicated picture of age-related immune deficiencies.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Song L,Kim YH,Chopra RK,Proust JJ,Nagel JE,Nordin AA,Adler WHdoi
10.1016/0531-5565(93)90058-lsubject
Has Abstractpub_date
1993-07-01 00:00:00pages
313-21issue
4-5eissn
0531-5565issn
1873-6815journal_volume
28pub_type
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