Abstract：
:DNA methylation patterns change as individuals grow older, and DNA methylation appears susceptible to modification by the diet. Thus DNA methylation may be a mechanism through which diet can affect aging and longevity. We propose that effects on DNA methylation also contribute to the extension in lifespan observed in response to dietary restriction. Relationships between diet-induced changes in DNA methylation and parallel effects on aging and/or lifespan could, of course, be purely associative. Proof of these ideas requires experimental model systems in which it is possible to manipulate genome methylation status and to measure effects on aging and/or lifespan. Commonly-used short-lived and genetically-malleable metazoan species, such as Caenorhabditis elegans and Drosophila, are not suitable for such studies; the C. elegans genome is not methylated, and DNA methylation in Drosophila is dissimilar from mammalian DNA methylation, occurring at cytosines at sites other than in CpG sequences. The honeybee provides a potentially unique and tractable model for such studies. Female larval development into the long-lived queen phenotype or short-lived worker is determined purely by diet (royal jelly) through an effect on DNA methylation, and honeybee DNA methylation mirrors that of the mammalian genome. Mammalian cell lines and biochemical approaches offer complementary tools to address specific components of hypotheses relating to effects of diet on aging through DNA methylation in a more targeted manner. Our studies using mammalian cell lines are revealing effects of Sirt1 on DNA methylation, and indicate that Sirt1 and resveratrol affect the expression of different sets of genes.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Ford Ddoi
10.1016/j.exger.2012.07.010subject
Has Abstractpub_date
2013-07-01 00:00:00pages
614-9issue
7eissn
0531-5565issn
1873-6815pii
S0531-5565(12)00200-8journal_volume
48pub_type
杂志文章,评审abstract：BACKGROUND:Inflammation plays a pivotal role in amyloid plaque progression thereby contributing to Alzheimer's disease-related neurodegeneration. We hypothesized that patients with Alzheimer's disease have an innate pro-inflammatory phenotype, as compared to control subjects without dementia. METHODS:Patients with a d...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00176-5
更新日期：2001-01-01 00:00:00
abstract：:Coronary heart disease is less prevalent in pre-menopausal women than in men, but increases at the onset of menopause. This delay is due to estrogen protective effects. The rise of cholesterolemia is one of the main risk factors for coronary disease. Since 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) is the ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.10.014
更新日期：2010-02-01 00:00:00
abstract：:Working from the hypothesis that modest deviations from physiological oxygen tension will influence cell characteristics important for infections/immunity and tumor development, cells were studied at three oxygen tensions during in vitro aging. Primary mouse embryo fibroblasts were established and subsequently passage...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(93)90046-g
更新日期：1993-11-01 00:00:00
abstract：OBJECTIVES:To investigate whether the implementation of a multifactorial falls intervention in nursing homes is cost-beneficial and alleviates the professional workload. DESIGN:A comprehensive quantitative model was developed to calculate the impact of investments in multifactorial falls prevention in nursing homes in...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111173
更新日期：2021-01-01 00:00:00
abstract：:The Senescence-Accelerated Mouse (SAM) strains are unique and appropriate models for genetic studies on aging because the SAMP strains have an "accelerated senescence" phenotype for which the SAMR strains are controls, and each SAMP strain has a strain-specific age-associated disorder. Furthermore, because they have g...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(96)00060-5
更新日期：1997-01-01 00:00:00
abstract：:In the central nervous system, the degree of decline in memory retrieval along the aging process depends on the quantity and quality of the stimuli received during lifetime. The cholinergic system modulates long-term potentiation and, therefore, memory processing. This study evaluated the spatial memory, the synaptic ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.05.055
更新日期：2013-08-01 00:00:00
abstract：:Age-related declines in human skeletal muscle performance may be caused, in part, by decreased responsivity of muscle fibers to calcium (Ca2+). This study examined the contractile properties of single vastus lateralis muscle fibers with various myosin heavy chain (MHC) isoforms (I, I/IIA, IIA and IIAX) across a range ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.12.007
更新日期：2018-02-01 00:00:00
abstract：:The hypotheses were: HISS-dependent insulin resistance (HDIR) accounts for insulin resistance that occurs with aging; HDIR is the initiating metabolic defect that leads progressively to type 2 diabetes and the metabolic syndrome; a synergistic antioxidant cocktail in chow confers protection against HDIR, subsequent sy...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2008.04.013
更新日期：2008-08-01 00:00:00
abstract：:Despite general belief that the mechanical properties of bone material contribute to whole bone strength, it is still obscure what the age effects are on mechanical behavior of the bone material, particularly in the case of the femoral neck trabeculae. In this study, atomic force microscopy was used for imaging and me...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2011.11.011
更新日期：2012-02-01 00:00:00
abstract：:Aging is one of the most basic properties of living organisms. Abundant evidence supports the idea that cell senescence underlies organismal aging in higher mammals. Therefore, examining the molecular mechanisms that control cell and replicative senescence is of great interest for biology and medicine. Several discove...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2010.01.009
更新日期：2010-03-01 00:00:00
abstract：:Calorie restriction (CR) and a reduced growth hormone (GH) signal affect insulin sensitivity and lifespan in mammals in a similar manner. We investigated the effects of CR and moderate inhibition of GH on glucose-stimulated activation of insulin signaling and the expression of genes related to fat metabolism in white ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.07.002
更新日期：2009-10-01 00:00:00
abstract：:The Tokyo Metropolitan Institute of Gerontology (TMIG) celebrates its 30th anniversary in 2002. Since its establishment, TMIG has been carrying out inter-disciplinary research on aging as a core institute in Japan and functions as a knowledge bank and a source for capable researchers of gerontology. The proportion of ...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(02)00169-9
更新日期：2002-12-01 00:00:00
abstract：:Senescence, a deteriorative process that increases the probability of death of an organism with increasing chronological age, has been found in all metazoans where careful studies have been carried out. There has been much controversy, however, about the potential immortality of hydra, a solitary freshwater member of ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(97)00113-7
更新日期：1998-05-01 00:00:00
abstract：:Several studies have shown that centenarians have better cardiovascular risk profiles compared to younger old people. Some reports have revealed that cardiovascular diseases (i.e. hypertension, diabetes, angina and/or myocardial infarction) are less common in centenarians respect to 70 and 80 years old persons. In ord...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2007.06.009
更新日期：2008-02-01 00:00:00
abstract：:Physical activity has been associated with alterations in telomere length, a potential indicator of biological aging, but several inconsistencies exist. Our aim was to investigate the associations between physical activity in midlife and leukocyte telomere length (LTL) measured in old age in the Helsinki Businessmen S...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2012.02.003
更新日期：2013-01-01 00:00:00
abstract：:Culturing Caenorhabditis elegans in axenic medium leads to a twofold increase in lifespan and considering the similar phenotypical traits with dietary restricted animals, it is referred to as axenic dietary restriction (ADR). The free radical theory of aging has suggested a pivotal role for mitochondria in the aging p...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.02.009
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Self-report questionnaires are widely used to assess physical function in older adults. However, they often lack a clear frame of reference and hence interpreting and rating task difficulty levels can be problematic for the responder. Consequently, the usefulness of traditional self-report questionnaires for...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.04.022
更新日期：2016-08-01 00:00:00
abstract：:Forkhead box O 3a (FoxO3a) has been known to link with aging process and senescence. In this study, we investigated the age-related changes of FoxO3a in the gerbil hippocampus using immunohistochemistry and western blot analysis. In the postnatal month 3 (PM 3) group, FoxO3a immunoreactivity was well detected in pyram...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2011.06.001
更新日期：2011-10-01 00:00:00
abstract：:The binding of advanced glycation endproducts (AGEs) to their receptors is known to cause changes in cell function during normal ageing and is implicated in the pathogenesis of cardiovascular disease. In this study, expression of the AGE-receptor 3 (AGE-R3) and the receptor for AGEs (RAGE) was compared on the mRNA and...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2003.12.006
更新日期：2004-03-01 00:00:00
abstract：:The role of the glucocorticoid receptor (GR) in senescence was studied in rats of increasing age. Statistically significant changes in the number of GRs from rat liver were detected, whereas the affinity for the ligand triamcinolone acetonide (TA) did not change with increasing age, and was in the range of 1-2 nM. In ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(99)00067-4
更新日期：1999-12-01 00:00:00
abstract：:The goal of these experiments was to determine if the increased longevity characteristics of our genetically selected long lived line of Drosophila could be attributed to metabolic differences. The data shows an inverse relationship between life span and temperature for both the long lived (L) and normal (R) strains; ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(88)90020-4
更新日期：1988-01-01 00:00:00
abstract：:We develop a theoretical model from an energetic viewpoint for unraveling the entangled effects of metabolic and biosynthetic rates on oxidative cellular damage accumulation during animal's growth, and test the model by experiments in hornworms. The theoretical consideration suggests that most of the cellular damages ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.05.015
更新日期：2016-09-01 00:00:00
abstract：:SIRT1 is a highly conserved NAD(+)-dependent protein deacetylase known to have protective effects against a variety of age-related diseases. However, there is a lack of information concerning SIRT1 expression in the cochlea and auditory cortex of C57BL/6 mice, a mouse model of age-related hearing loss. Using RT-PCR an...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.12.006
更新日期：2014-03-01 00:00:00
abstract：:Spectrins are a part of cytoskeletal platform that lines the intracellular side of plasma membrane, which can be proteolyzed by calcium-sensitive enzymes including calpains and caspases. Caspase-3 mediated αII-spectrin proteolysis results in the release of a 120kDa spectrin breakdown product (SBDP120), known to occur ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.06.003
更新日期：2015-09-01 00:00:00
abstract：:There have been some observations that low body weight and a low level of some hormones (e.g. IGF-1) during the first half of life are predictors of longer life in mice. However, contradictions in the available data on the biomarkers of aging and predictors of longevity have shown that the research in these fields has...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2003.12.007
更新日期：2004-03-01 00:00:00
abstract：:Mitochondria generate much of the cellular energy through the process of oxidative phosphorylation (OXPHOS). OXPHOS function may be affected by a mutation in any of the mitochondrial (mt) DNA encoded genes and/or nuclear encoded genes that produce proteins imported into the mitochondrion that form (or assemble) the fi...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2005.07.014
更新日期：2005-10-01 00:00:00
abstract：:Reactive oxygen species (ROS) play important roles in cellular senescence and organismic aging. Furthermore, they have been implicated in some of the adverse effects of chronic stress due to elevated peripheral levels of catecholamines. Here, we applied three different techniques to individually compare the systemic a...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2007.08.003
更新日期：2007-11-01 00:00:00
abstract：:It has been suggested that alterations in Na(+),K(+)-ATPase mediate the development of several aging-related pathologies, such as hypertension and diabetes. Thus, we evaluated Na(+),K(+)-ATPase function and H(2)O(2) production in the renal cortex and medulla of Wistar Kyoto (WKY) rats at 13, 52 and 91 weeks of age. Cr...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2010.09.012
更新日期：2010-12-01 00:00:00
abstract：:The geriatric populations of many countries are growing rapidly and they present major problems to healthcare infrastructures from both medical and economic perspectives. The elderly are predisposed to a variety of diseases, which contribute to a marked increase in morbidity in this subpopulation. The incidence of liv...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2005.06.009
更新日期：2005-08-01 00:00:00
abstract：:An age-related increase of DNA damage/mutation has been previously reported in human lymphocytes. The high copy number and mutation rate make the mtDNA genome an ideal candidate for assessing damage and to act as a potential biomarker of ageing. In the present study, two assays were developed to evaluate the level of ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(01)00200-5
更新日期：2002-01-01 00:00:00
