Patients with Alzheimer's disease display a pro-inflammatory phenotype.

abstract：:Previous studies have indicated that genetic variations in the factors of insulin/insulin-like growth factor 1 (IGF-1) signaling pathway could influence human life-span by affecting IGF-1 levels. The promoter region of the IGF-1 gene is an obvious candidate and has not been studied clearly. To explore the potential ro...

journal_title：Experimental gerontology

authors： Xie L,Gong YY,Lian SG,Yang J,Yang Y,Gao SJ,Xu LY,Zhang YP

更新日期：2008-10-01 00:00:00

abstract：:The CG9940 gene, which encodes the NAD(+) synthase protein in Drosophila, is conserved in human, zebra fish, and mosquito. NAD(+) synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic a...

journal_title：Experimental gerontology

authors： Wen DT,Zheng L,Ni L,Wang H,Feng Y,Zhang M

更新日期：2016-10-01 00:00:00

abstract：:Age-related hearing loss (AHL) is a progressive neurodegenerative disease that is largely silent in its initial stages. There is no sensitive blood biomarker for diagnosis or early detection of AHL. MicroRNAs (miRNAs or miRs) are abundant and highly stable in blood, and have been recently described as powerful circula...

journal_title：Experimental gerontology

authors： Pang J,Xiong H,Yang H,Ou Y,Xu Y,Huang Q,Lai L,Chen S,Zhang Z,Cai Y,Zheng Y

更新日期：2016-04-01 00:00:00

abstract：:For more than 60 years the only dietary manipulation known to retard aging was caloric restriction, in which a variety of species respond to a reduction in energy intake by demonstrating extended median and maximum life span. More recently, two alternative dietary manipulations have been reported to also extend surviv...

journal_title：Experimental gerontology

authors： Zimmerman JA,Malloy V,Krajcik R,Orentreich N

更新日期：2003-01-01 00:00:00

abstract：:A growing body of research in elderly populations suggests that the early phase of an explosive muscle contraction (i.e., ≤200 ms) may be more functionally relevant than peak values. However, age-related variation in early phase explosive strength has never been investigated across the full-adult life span. This cross...

journal_title：Experimental gerontology

authors： Van Roie E,Van Driessche S,Inglis AJ,Thomis M,Delecluse C

更新日期：2018-09-01 00:00:00

abstract：:Orally-administered catechin has long been known to have several beneficial effects on the mammalian host, however, the effects of orally supplemented catechin on the host through gingival tissues have not yet been established. Here, we elucidated the effects of orally supplemented catechin in the rat heart blood mito...

journal_title：Experimental gerontology

authors： Cueno ME,Tamura M,Imai K,Ochiai K

更新日期：2013-11-01 00:00:00

abstract：:Aging has a profound effect on the immune system, and both innate and adaptive arms of the immune system show functional decline with age. In response to infection with intracellular microorganisms, old animals mobilize decreased numbers of antigen-specific CD8+ T cells with reduced production of effector molecules an...

journal_title：Experimental gerontology

authors： Jergović M,Smithey MJ,Nikolich-Žugich J

更新日期：2018-05-01 00:00:00

abstract：:Post-translational oxidative protein modifications which are more marked during aging and/or high-calorie (HC) diets affect protein function and metabolism. Protein function and metabolism are different according to the type of muscle proteins. Oxidative muscle protein modifications may thus be associated with age-rel...

journal_title：Experimental gerontology

authors： Murakami H,Guillet C,Tardif N,Salles J,Migné C,Boirie Y,Walrand S

更新日期：2012-02-01 00:00:00

abstract：:Reductive stress, which is due to a paradoxical excess of antioxidants such as reduced glutathione (GSH) and GSH-related enzymes associated with decreased oxidant levels, has emerged as a pathogenetic mechanism of myocardial damage in pathological conditions such as protein aggregation cardiomyopathy. Notably, in the ...

journal_title：Experimental gerontology

authors： Lapenna D,Ciofani G,Lelli Chiesa P,Porreca E

更新日期：2020-02-06 00:00:00

abstract：:Studies have suggested that older individuals are more fatigable than young adults when power loss, measured during single-joint contractions, is considered the fatigue index; however, age-related differences in fatigue considering power measurements during multi-joint movements (e.g., cycling) have not been fully elu...

journal_title：Experimental gerontology

authors： Krüger RL,Aboodarda SJ,Jaimes LM,Vaz MA,Samozino P,Millet GY

更新日期：2020-05-01 00:00:00

abstract：:Heat shock proteins (HSP's) closely interact with 20S proteasome and have been shown to maintain catalytic activity, responsible for the prevention of protein aggregation. A decrease in both proteasome activity and heat shock proteins (HSP's) has been observed with age. We investigated whether life-long calorie restri...

journal_title：Experimental gerontology

authors： Selsby JT,Judge AR,Yimlamai T,Leeuwenburgh C,Dodd SL

更新日期：2005-01-01 00:00:00

abstract：:The effect of 3-(4-pyridyl)-1,2,4-thiotriazolyl 5-mercaptoacetic acid kalium salt (Rumosol) and 3-(4-pyridyl)-1,2,4-thiotriazolyl 5-mercaptoacetic acid morpholinium salt (drug 2) on the concentration of Schiff base in myocardium of adult (10-12 months) and old (22-25 months) Wistar rats during immobilized stress were ...

journal_title：Experimental gerontology

authors： Davydov VV,Shvets VN

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the effects of 12 weeks of traditional resistance training (TRT) or resistance training using Cluster-set (CS) on functional performance and physical fitness of postmenopausal and elderly women. METHODS:Participants (61.1 ± 4.9 years, body mass 64.5 ± 1.8 kg, height 155.7...

journal_title：Experimental gerontology

authors： Dias RKN,Penna EM,Noronha ASN,de Azevedo ABC,Barbalho M,Gentil PV,Coswig VS

更新日期：2020-09-01 00:00:00

abstract：:We have recently reported that activated mouse spleen mononuclear cells (MNCs) efficiently lyse autologous erythrocytes in vitro (Saxena and Chandrasekhar, 2000). In the present study, we have investigated erythrocyte-depleting ability (EDA) of spleen MNCs from young and old mice. Time kinetics of survival of erythroc...

journal_title：Experimental gerontology

authors： Saxena RK,Adler WH

更新日期：2000-05-01 00:00:00

abstract：:In many eukaryotes oxidative phosphorylation via the mitochondrial electron transport chain provides the major means of ATP production. Complete removal of this capacity often results in premature death. Recent studies using the nematode Caenorhabditis elegans are surprising because they have revealed that disruption ...

journal_title：Experimental gerontology

authors： Rea SL

更新日期：2005-11-01 00:00:00

abstract：:Forkhead box O 3a (FoxO3a) has been known to link with aging process and senescence. In this study, we investigated the age-related changes of FoxO3a in the gerbil hippocampus using immunohistochemistry and western blot analysis. In the postnatal month 3 (PM 3) group, FoxO3a immunoreactivity was well detected in pyram...

journal_title：Experimental gerontology

authors： Park JH,Lee CH,Yoo KY,Choi JH,Hwang IK,Lee JY,Kang IJ,Won MH

更新日期：2011-10-01 00:00:00

abstract：:In the present study, using RNA gel-blot analysis, we characterized the developmental changes in the prevalence of mRNA coding for fibronectin (FN), glial fibrillary acidic protein (GFAP), neurotrophic protein S100 beta, and beta-actin mRNA in rat hippocampus and forebrain from 1 to 720 days of age. We found that the ...

journal_title：Experimental gerontology

authors： Wagner AP,Reck G,Platt D

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Epidemiological and objective studies report an association between sedentary time and lower risk of the metabolic syndrome (MetS) and its risk factors in young and middle-age adults. To date, there is a lack of objective data on the association between sedentary time and MetS among older adults. METHODS:Th...

journal_title：Experimental gerontology

authors： Mankowski RT,Aubertin-Leheudre M,Beavers DP,Botoseneanu A,Buford TW,Church T,Glynn NW,King AC,Liu C,Manini TM,Marsh AP,McDermott M,Nocera JR,Pahor M,Strotmeyer ES,Anton SD,LIFE Research Group.

更新日期：2015-10-01 00:00:00

abstract：:This study investigated the effects of two training programmes of 6 weeks combining strength and balance exercises in different proportions. One training programme [n=10; 71.4 (6.3) years] consisted mainly of strength exercises (ST) and the other programme [n=8; 71.4 (6.4) years] included a majority of balance exercis...

journal_title：Experimental gerontology

authors： Penzer F,Duchateau J,Baudry S

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Hyaline articular cartilage, which protects the bones of diarthrodial joints from forces associated with load bearing, frictions, and impacts has very limited capacities for self-repair. Over the years, the trend of treatments has shifted to regenerations and researchers have been on the quest for a lasting ...

journal_title：Experimental gerontology

authors： Ude CC,Shamsul BS,Ng MH,Chen HC,Ohnmar H,Amaramalar SN,Rizal AR,Johan A,Norhamdan MY,Azizi M,Aminuddin BS,Ruszymah BHI

更新日期：2018-04-01 00:00:00

abstract：:The long life spans and slow aging rates of birds relative to mammals are paradoxical in view of birds' high metabolic rates, body temperatures and blood glucose levels, all of which are predicted to be liabilities by current biochemical theories of aging. Available avian life-table data show that most birds undergo r...

journal_title：Experimental gerontology

authors： Holmes DJ,Flückiger R,Austad SN

更新日期：2001-04-01 00:00:00

abstract：:The Senescence-Accelerated Mouse (SAM) strains are unique and appropriate models for genetic studies on aging because the SAMP strains have an "accelerated senescence" phenotype for which the SAMR strains are controls, and each SAMP strain has a strain-specific age-associated disorder. Furthermore, because they have g...

journal_title：Experimental gerontology

authors： Higuchi K

更新日期：1997-01-01 00:00:00

abstract：:In the present paper, we investigated whether the phenotype, the antigen-presenting capacity, and the migration of antigen-presenting cells (APCs), are affected by the aging process. APCs were obtained incubating peritoneal monocyte-macrophage cells with granulocyte-macrophage colony-stimulating factor (GM-CSF) (immat...

journal_title：Experimental gerontology

authors： Donnini A,Argentati K,Mancini R,Smorlesi A,Bartozzi B,Bernardini G,Provinciali M

更新日期：2002-08-01 00:00:00

abstract：:Type 2 diabetes is associated with progressive beta-cell failure manifest as a decline in insulin secretion and increasing hyperglycemia. A growing body of evidence suggests that beta-cell failure in type 2 diabetes correlates with the formation of pancreatic islet amyloid deposits, indicating that islet amyloid may h...

journal_title：Experimental gerontology

authors： Marzban L,Park K,Verchere CB

更新日期：2003-04-01 00:00:00

abstract：:Increased lifespan can be associated with greater resistance to many different stressors, most notably thermal stress. Such hormetic effects have also been found in C. elegans where short-term exposure to heat lengthens the lifespan. Genetic investigations have been carried out using mutation perturbations in a single...

journal_title：Experimental gerontology

authors： Rodriguez M,Snoek LB,Riksen JA,Bevers RP,Kammenga JE

更新日期：2012-08-01 00:00:00

abstract：:Aging is an independent risk factor for the development of atherosclerosis, a vascular abnormality that plays a significant role in the development of many cardiovascular disorders. Animal experiments have demonstrated that aging predisposes the vasculature to advanced atherosclerotic disease and vessel injury and tha...

journal_title：Experimental gerontology

authors： Lundberg MS,Crow MT

更新日期：1999-07-01 00:00:00

abstract：:Aberrant mineralization of soft connective tissues (ectopic calcification) may occur as a frequent age-related complication. Still, it remains unclear the role of mesenchymal cell donor's age and of replicative senescence on ectopic calcification. Therefore, the ability of cells to deposit in-vitro hydroxyapatite crys...

journal_title：Experimental gerontology

authors： Boraldi F,Bartolomeo A,Di Bari C,Cocconi A,Quaglino D

更新日期：2015-12-01 00:00:00

abstract：:In this study we report the identification of FAH domain containing protein 1 (FAHD1), a recently described member of the fumarylacetoacetate hydrolase (FAH) superfamily of metabolic enzymes, as a novel player in the regulation of cellular senescence. FAHD1 was found in a proteomic screen searching for mitochondrial p...

journal_title：Experimental gerontology

authors： Petit M,Koziel R,Etemad S,Pircher H,Jansen-Dürr P

更新日期：2017-06-01 00:00:00

abstract：:With many caveats to the traditional vertebrate species pertaining to biogerontology investigations, it has been suggested that a most informative model is the one which: 1) examines closely related species, or various members of the same species with naturally occurring lifespan variation, 2) already has adequate med...

journal_title：Experimental gerontology

authors： Gilmore KM,Greer KA

更新日期：2015-11-01 00:00:00

abstract：:Mitochondrial superoxide production is an important source of reactive oxygen species in cells, and may cause or contribute to ageing and the diseases of ageing. Seven major sites of superoxide production in mammalian mitochondria are known and widely accepted. In descending order of maximum capacity they are the ubiq...

journal_title：Experimental gerontology

authors： Brand MD

更新日期：2010-08-01 00:00:00