Abstract:
:Several studies have shown that centenarians have better cardiovascular risk profiles compared to younger old people. Some reports have revealed that cardiovascular diseases (i.e. hypertension, diabetes, angina and/or myocardial infarction) are less common in centenarians respect to 70 and 80 years old persons. In order to explain this evidence, there is a growing number of hypothesis that consider a combination of genetic factors and lifestyle aspects to elucidate the exceptional longevity of centenarians, able to overcome the most frequent mortality cause, which is a cardiovascular event. It has been suggested that a role on this better cardiovascular risk profile may be played by the increasing use of pharmacologic treatments in the elderly population (specially for hypertension and dyslipidemia), but the contribution of drug treatments to promote extreme longevity is not confirmed. Furthermore, centenarians in general have needed fewer drugs at younger ages due to a healthy lifestyle. The importance of the genetic contribution is demonstrated by the inheritance of low-risk cardiovascular profiles in centenarian offspring and lower prevalence of cardiovascular diseases in this population as compared with their spouses or with age-matched subjects without centenarian parents. Another advantage in centenarians' offspring seems to be a delay in the onset for cardiovascular diseases, respect to age- and sex-matched controls. Cardiovascular risk factors mirror the factors that contribute to longevity. Hence, it is not surprising that these risk factors are less prevalent in centenarians when compared to younger old individuals.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Galioto A,Dominguez LJ,Pineo A,Ferlisi A,Putignano E,Belvedere M,Costanza G,Barbagallo Mdoi
10.1016/j.exger.2007.06.009subject
Has Abstractpub_date
2008-02-01 00:00:00pages
106-13issue
2eissn
0531-5565issn
1873-6815pii
S0531-5565(07)00141-6journal_volume
43pub_type
杂志文章,评审abstract::Aging is associated with an increased incidence of heart failure, but the existence of an age-related cardiomyopathy remains controversial. Differences in strain, age and technique of measuring cardiac function differ between experiments, confounding the interpretation of these studies. Additionally, the structural an...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2011.02.010
更新日期:2011-07-01 00:00:00
abstract::Coronary heart disease is less prevalent in pre-menopausal women than in men, but increases at the onset of menopause. This delay is due to estrogen protective effects. The rise of cholesterolemia is one of the main risk factors for coronary disease. Since 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) is the ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2009.10.014
更新日期:2010-02-01 00:00:00
abstract::The long life spans and slow aging rates of birds relative to mammals are paradoxical in view of birds' high metabolic rates, body temperatures and blood glucose levels, all of which are predicted to be liabilities by current biochemical theories of aging. Available avian life-table data show that most birds undergo r...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(00)00247-3
更新日期:2001-04-01 00:00:00
abstract::The binding of advanced glycation endproducts (AGEs) to their receptors is known to cause changes in cell function during normal ageing and is implicated in the pathogenesis of cardiovascular disease. In this study, expression of the AGE-receptor 3 (AGE-R3) and the receptor for AGEs (RAGE) was compared on the mRNA and...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2003.12.006
更新日期:2004-03-01 00:00:00
abstract::The ascorbic acid content of Drosophila melanogaster was found to be high in the absence of a dietary source. The amount of ascorbic acid per fly declined with aging in both the Oregon R and Swedish C strains. The median life span at 25 degrees C was 45 days for Swedish C and 59 days for Oregon R. The amount of ascorb...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(91)90037-m
更新日期:1991-01-01 00:00:00
abstract::Since,D-galactose (D-gal) overload model has been used as a premature aging model, we hypothesized that it may also lead to accelerated aging in the inner ear. Furthermore, though the mitochondrial DNA (mtDNA) 4834 bp deletion mutation has been considered as the marker of aging, there is no information available in th...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2006.04.008
更新日期:2006-06-01 00:00:00
abstract::Accumulation of oxidative stress-induced damage in brain tissue plays an important role in the pathogenesis of normal aging and neurodegenerative diseases. Neuronal oxidative damage typically increases with age in humans, and also in the invertebrate and vertebrate model species most commonly used in aging research. B...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2006.08.004
更新日期:2006-11-01 00:00:00
abstract::Alzheimer's disease (AD) is characterized by the accumulation and aggregation of misfolded proteins. The presence of misfolded proteins in the endoplasmic reticulum (ER) triggers a cellular stress response called the unfolded protein response (UPR). Previously, we have shown that the UPR is activated in AD neurons. In...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2006.01.013
更新日期:2006-04-01 00:00:00
abstract::SIRT1 is a highly conserved NAD(+)-dependent protein deacetylase known to have protective effects against a variety of age-related diseases. However, there is a lack of information concerning SIRT1 expression in the cochlea and auditory cortex of C57BL/6 mice, a mouse model of age-related hearing loss. Using RT-PCR an...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.12.006
更新日期:2014-03-01 00:00:00
abstract::Degeneration of tongue muscles with aging may contribute to swallowing deficits observed in elderly people. However, the capacity for tongue muscle stem cells (SCs) to regenerate and repair the aged tongue and improve tongue strength following tongue exercise (a current clinical treatment) has never been examined. We ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.111104
更新日期:2020-12-01 00:00:00
abstract::Declines in mobility with advancing age are often associated with a reduction in the use of lower leg muscles. We examined the influence of two interventions that involved neuromuscular electrical stimulation (NMES) applied to the triceps surae muscles on the mobility and muscle function of older adults. Thirty health...
journal_title:Experimental gerontology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.exger.2018.04.018
更新日期:2018-07-15 00:00:00
abstract::Dietary restriction extends lifespan in a variety of organisms, but the key nutritional components driving this process and how they interact remain uncertain. In Drosophila, while a substantial body of research suggests that protein is the major dietary component affecting longevity, recent studies claim that carbohy...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.02.003
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Several studies reported an association between concentrations of serum uric acid and cognitive function, but the evidence is contradictory. It is known that uric acid is associated with cardiovascular diseases, especially among women. Stratifying by sex and history of cardiovascular disease may clarify whet...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2016.04.017
更新日期:2016-08-01 00:00:00
abstract::Average life expectancy at birth is a rough measure of the span of healthy, productive life--the functional life span. In the developed countries average life expectancies at birth now range from 76-79 years, six to nine years less than the limit of about 85 years imposed by aging. Aging is the accumulation of changes...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(97)00059-4
更新日期:1998-01-01 00:00:00
abstract::Engineering of fetal tissue has a high potential for the treatment of acute and chronic wounds of the skin in humans as these cells have high expansion capacity under simple culture conditions and one organ donation can produce Master Cell Banks which can fabricate over 900 million biological bandages (9 x 12cm). In a...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2008.11.004
更新日期:2009-03-01 00:00:00
abstract::Spatial memory deficits occur earlier in female than male rodents as the animals age, and the cessation of estrous cycle has been suggested to play a role in this phenomenon. We examined the effects of long-term ovariectomy (OVX) and estrogen replacement therapy (ERT) with subcutaneous 17beta-estradiol minipellets on ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2004.05.005
更新日期:2004-09-01 00:00:00
abstract::Diseases of the elderly, including neurodegenerative and cardiovascular disorders and cancer, may develop through the accumulation of "hits" composed of genetic and epigenetic risk factors. The "iceberg" buildup of these hits over time may exceed the tolerance threshold of a particular tissue, thus precipitating disea...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(96)00156-8
更新日期:1997-07-01 00:00:00
abstract::A correct clinical diagnosis in the early stage of Alzheimer Disease (AD) is mandatory given the current available treatment with acetylcholine esterase inhibitors. Moreover, a early to preclinical diagnosis would allow to identify patients eligible for future disease-modifying therapies. In the last ten years, we hav...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2009.08.004
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:An intermission in the training routine, in which older adults refrain from regular structured exercise, may have deleterious effects on muscle performance and bioelectric phase angle (PhA), which is a predictive marker for cellular integrity. PURPOSE:To determine the effects of a 2-week detraining period o...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.111175
更新日期:2021-02-01 00:00:00
abstract::To study the several elements and causes of ageing, diverse model organisms and methodologies are required. The most frequently used models are Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster and rodents. All have their advantages and disadvantages and allow studying particular aspects of the...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2008.11.007
更新日期:2009-04-01 00:00:00
abstract::Aging is associated with a decline in muscle force that exceeds loss of muscle mass, suggesting that factors other than sarcopenia affect age-related muscle weakness. Here, we investigate in situ muscle force and sarcoplasmic reticulum (SR) properties in gastrocnemius muscles of adult (6-8 months) and aged (24 months)...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.11.018
更新日期:2014-02-01 00:00:00
abstract::The aging process is known to be regulated by specific genes in various organisms, including yeast, the nematode C. elegans, fruitflies and mice. To explore the novel genes involved in aging process, we applied cDNA microarray technology to a replicative senescence model of human dermal fibroblasts (HDF). Eighty-four ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2004.07.002
更新日期:2004-09-01 00:00:00
abstract::Despite well-documented evidence for lifespan extension by methionine restriction (MR), underlying mechanisms remain unknown. As methionine can alter S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), the substrate and product of DNA methyltransferase-1 (DNMT1), we hypothesized that MR diet alters DNA methyl...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2016.12.003
更新日期:2017-02-01 00:00:00
abstract::Accumulation of altered proteins is the most common molecular symptom of ageing. Altered proteins are also associated with many age-related pathologies. Altered proteins are continuously produced but are normally selectively degraded by cellular proteases; their accumulation during ageing may be explained by either or...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2006.03.004
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:This study aimed to evaluate the effect of vitamin D3 megadose supplementation and influence of BsmI polymorphism in the VDR gene on the inflammatory profile and oxidative stress in elderly women with vitamin D deficiency. METHODS:A double blind, randomized, placebo-controlled trial was conducted with 40 eld...
journal_title:Experimental gerontology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.exger.2015.03.011
更新日期:2015-06-01 00:00:00
abstract::The aim of the present study was to compare the effects of water-based aerobic training and water-based resistance training on muscular strength and cardiorespiratory fitness in older women. Sixty-nine individuals were randomized into the following three groups: the water-based aerobic training (WA, n = 23) group, the...
journal_title:Experimental gerontology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.exger.2018.04.022
更新日期:2018-07-15 00:00:00
abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disorder with characteristic neuropathological features that are accompanied by inflammatory processes and release of pro-inflammatory cytokines. There is evidence that microglial cells are a key mediator of damage in AD. The microglial compartment may arise ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2009.10.005
更新日期:2010-01-01 00:00:00
abstract::We investigated the telomere lengths of individual cell types in lingual mucosa using an improved tissue quantitative fluorescence in situ hybridization (Q-FISH) method. Our tissue Q-FISH method compensates for partially cut nuclei in a tissue section by using the telomere:centromere ratio (TCR). We normalized our TCR...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2008.06.001
更新日期:2008-09-01 00:00:00
abstract::Reactive oxygen species (ROS) play important roles in cellular senescence and organismic aging. Furthermore, they have been implicated in some of the adverse effects of chronic stress due to elevated peripheral levels of catecholamines. Here, we applied three different techniques to individually compare the systemic a...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2007.08.003
更新日期:2007-11-01 00:00:00
abstract::To test if the adrenocortical axis of the rat loses sensitivity to negative feedback control during aging, we examined corticosterone secretion under basal, stressed and post-stress conditions in young and in aged Fisher male rats. We find no age-related change in the speed or magnitude of the stress response or in th...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(83)90051-7
更新日期:1983-01-01 00:00:00