FoxO3a immunoreactivity is markedly decreased in the dentate gyrus, not the hippocampus proper, of the aged gerbil.

abstract：:We have recently reported that activated mouse spleen mononuclear cells (MNCs) efficiently lyse autologous erythrocytes in vitro (Saxena and Chandrasekhar, 2000). In the present study, we have investigated erythrocyte-depleting ability (EDA) of spleen MNCs from young and old mice. Time kinetics of survival of erythroc...

journal_title：Experimental gerontology

authors： Saxena RK,Adler WH

更新日期：2000-05-01 00:00:00

abstract：AIM:Sirtuins are proteins that connect energy metabolism, oxidative stress and aging. Expression of heat shock proteins (Hsps) is regulated by heat shock factors (HSFs) in response to various environmental and physiological stresses, such as oxidative stress. Oxidative stress accumulates during aging which makes cells ...

journal_title：Experimental gerontology

authors： Karvinen S,Silvennoinen M,Vainio P,Sistonen L,Koch LG,Britton SL,Kainulainen H

更新日期：2016-06-15 00:00:00

abstract：:Reductions in physical performance, cognitive impairment (CI) and decline (CD), are common in older age, but few prospective cohort studies have considered the relationship between these domains. In this study we investigated whether reduced physical performance and low handgrip/lower limbs strength, could predict a h...

journal_title：Experimental gerontology

authors： Veronese N,Stubbs B,Trevisan C,Bolzetta F,De Rui M,Solmi M,Sartori L,Musacchio E,Zambon S,Perissinotto E,Crepaldi G,Manzato E,Sergi G

更新日期：2016-08-01 00:00:00

abstract：:Telomeres are specialised structures located at the end of eukaryotic chromosomes, that get short during progressive cell divisions. Therefore, telomere may be an indicator of the mitotic history of a cell and it is also a determining factor for the residual cell life span. One mechanism, compensating for the telomere...

journal_title：Experimental gerontology

authors： Mariani E,Meneghetti A,Formentini I,Neri S,Cattini L,Ravaglia G,Forti P,Facchini A

更新日期：2003-06-01 00:00:00

abstract：:We have developed a simian virus 40 (SV40) T-antigen immortalized human cell line, 1MR90-D305.2H4 (IDH4), in which the expression of T-antigen is controlled by the mouse mammary tumor virus (MMTV) promoter and thus regulated by steroids such as dexamethasone. Studies on the regulation of proliferation by T-antigen led...

journal_title：Experimental gerontology

authors： Shay JW,West MD,Wright WE

更新日期：1992-09-01 00:00:00

abstract：:Fetal and placental weights and peripheral blood progestagen concentrations were examined on days 13, 16 and 22 of gestation in young (3-5 month) nulliparous and old (9-12 month) multiparous, albino Wistar rats. There was no difference in fetal weights at any stage examined whereas placental weights were significantly...

journal_title：Experimental gerontology

authors： Rahima A,Bruce NW

更新日期：1987-01-01 00:00:00

abstract：:A mathematical model of cellular metabolism is used to relate the rates of cell division and waste production to the concentrations of oxygen and glucose in the medium in which a normal diploid cell culture is grown. The metabolic model in tandem with an earlier waste-content model based on the waste-product theory of...

journal_title：Experimental gerontology

authors： Hirsch HR,Witten M

更新日期：1991-01-01 00:00:00

abstract：:Dietary restriction (DR) has multiple and essential effects in protecting against DNA damage in model organisms. Persistent DNA damage plays a central role in the process of aging. Senescence-associated secretory phenotype (SASP), as a product of cellular aging, can accelerate the process of cellular senescence as a f...

journal_title：Experimental gerontology

authors： Wang W,Cai G,Chen X

更新日期：2018-07-01 00:00:00

abstract：:Light and electron microscope comparisons were made of parotid and submandibular glands from male Swiss-Webster white mice 3, 13, and 18 months old. The glands from the 13- and 18-month-old mice were less organized and the parenchyma was not as dense. Fibrous connective tissue, intracellular lipofuscin granules, and r...

journal_title：Experimental gerontology

authors： Meisel DL,Skobe Z,Prostak KS,Shklar G

更新日期：1988-01-01 00:00:00

abstract：:MCP-1 and RANTES are molecules that regulate monocyte and T-lymphocyte recruitment towards sites of inflammation. We sought to evaluate the role of these chemokines in Alzheimer's disease (AD), and the effect of acetylcholinesterase inhibitor (AchEI) therapy on their release from peripheral blood mononuclear cells (PB...

journal_title：Experimental gerontology

authors： Iarlori C,Gambi D,Gambi F,Lucci I,Feliciani C,Salvatore M,Reale M

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:To explore the impact of diabetic peripheral neuropathy (DPN) on the recovery of older persons with diabetes mellitus (DM) after hip-fracture surgery. DESIGN, SETTING, PARTICIPANTS:Secondary data for this study came from a clinical trial on the effectiveness of a DM-specific care model for 176 ol...

journal_title：Experimental gerontology

authors： Tseng MY,Huang YF,Liang J,Wang JS,Yang CT,Wu CC,Cheng HS,Chen CY,Lin YE,Wang WS,Shyu YL

更新日期：2019-05-01 00:00:00

abstract：:DNA binding of the ku protein was investigated in peripheral blood mononuclear cells (PBMC) from 24 subjects of different ages (20-89 years old) displaying age-related changes in DNA repair, mitotic responsiveness, and cytokine production. Ku is an heterodimeric protein composed of two subunits of 70 and 80 kDa, which...

journal_title：Experimental gerontology

authors： Frasca D,Barattini P,Tirindelli D,Guidi L,Bartoloni C,Errani A,Costanzo M,Tricerri A,Pierelli L,Doria G

更新日期：1999-08-01 00:00:00

abstract：:A growing body of research in elderly populations suggests that the early phase of an explosive muscle contraction (i.e., ≤200 ms) may be more functionally relevant than peak values. However, age-related variation in early phase explosive strength has never been investigated across the full-adult life span. This cross...

journal_title：Experimental gerontology

authors： Van Roie E,Van Driessche S,Inglis AJ,Thomis M,Delecluse C

更新日期：2018-09-01 00:00:00

abstract：:Aged traumatic brain injury (TBI) patients suffer higher rates of mortality and disability than younger patients. Cognitive problems common to TBI patients are associated with damage to the hippocampus, a central locus of learning and memory. To investigate the molecular mechanisms of age-related vulnerability to brai...

journal_title：Experimental gerontology

authors： Shah SA,Prough DS,Garcia JM,DeWitt DS,Hellmich HL

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Homocysteine (Hcy) high levels are associated with fractures, bone resorption and an early onset of osteoporosis in elderly persons; a relationship between Hcy and bone formation has also been suggested but is still controversial. Frailty, an independent predictor of fractures and decreased bone mineral dens...

journal_title：Experimental gerontology

authors： Álvarez-Sánchez N,Álvarez-Ríos AI,Guerrero JM,García-García FJ,Rodríguez-Mañas L,Cruz-Chamorro I,Lardone PJ,Carrillo-Vico A

更新日期：2018-07-15 00:00:00

abstract：OBJECTIVE:To assess the effect of genetic and non-genetic factors on indicators derived from waist circumference (WC) and body mass index (BMI) as well as inter-indicator differences in risk assessment age-related diseases including diabetes mellitus, coronary heart disease and liver cancer. METHODS:Height, weight and...

journal_title：Experimental gerontology

authors： Xin G,Shong L,Hui L

更新日期：2014-12-01 00:00:00

abstract：:Human diploid lung fibroblasts (IMR-90) were used to investigate the reported increase in beta-adrenergic-stimulated cyclic adenosine 3',5'-monophosphate (cAMP) levels in fibroblasts aged in culture. Under basal conditions cellular cAMP was 34.2 +/- 5.6 and 38.4 +/- 9.1 pmol/mg protein in early (PDL 22-24) and late (P...

journal_title：Experimental gerontology

authors： Ethier MF,Medeiros M,Romano FD,Dobson JG Jr

更新日期：1992-01-01 00:00:00

abstract：:Post-viral pneumococcal pneumonia is a leading morbidity and mortality in older patients (≥65years of age). The goal of our current study is to understand the impact of chronological aging on innate immune responses to a secondary, post viral infection with Streptococcus pneumoniae, a causative agent of bacterial pneu...

journal_title：Experimental gerontology

authors： Cho SJ,Plataki M,Mitzel D,Lowry G,Rooney K,Stout-Delgado H

更新日期：2018-05-01 00:00:00

abstract：:This study examined the beneficial effects of black rice anthocyanin extract (BRAE), which provides as an excellent source of dietary antioxidants, on the lifespan of fruit flies and the underlying molecular mechanisms. Results showed that supplementation of BRAE extended the lifespan of fruit flies by 20% and retarde...

journal_title：Experimental gerontology

authors： Li X,Zhang Z,Zhang X,Cheng J,Liu D,Yan Y,Wang H

更新日期：2019-05-01 00:00:00

abstract：:We studied the contractile, histological and biochemical characteristics of regenerating slow (soleus) muscles of aged rats and the effect of IGF-1 treatment on these parameters. Regenerating soleus muscles were studied 21 days after myotoxic injury. In senescent rats (24 month old), the in situ isometric maximal teta...

journal_title：Experimental gerontology

authors： Vignaud A,Noirez P,Besse S,Rieu M,Barritault D,Ferry A

更新日期：2003-05-01 00:00:00

abstract：:Brain aging, Alzheimer disease and stroke share common elements of deficits in calcium regulation, declines in mitochondrial function, increases in generation of reactive oxygen species (ROS), accumulated damage from ROS and immune system dysfunction. The problem is to distinguish less significant side reactions, such...

journal_title：Experimental gerontology

authors： Brewer GJ

更新日期：2000-12-01 00:00:00

abstract：:In order to clarify immunogenetic markers contributing to successful aging, HLA and cytokine gene profiles were analyzed in healthy elderly Bulgarians. Family segregation analysis was performed to define combined effect of haplotypes and immunophenotype profiles. The results of this study did not reveal any statistica...

journal_title：Experimental gerontology

authors： Naumova E,Mihaylova A,Ivanova M,Michailova S,Penkova K,Baltadjieva D

更新日期：2004-04-01 00:00:00

abstract：:The effect of age on brain muscarinic receptor density is unclear. Some in vivo neuroimaging studies have reported a large age-related reduction in muscarinic receptor density; however, others have reported increases or no change. The variability in these results most likely arises because of the heterogeneity of the ...

journal_title：Experimental gerontology

authors： Norbury R,Travis MJ,Erlandsson K,Waddington W,Owens J,Pimlott S,Ell PJ,Murphy DG

更新日期：2005-03-01 00:00:00

abstract：:Prior to three months of age there is little melatonin (MLT) secretion in humans. MLT production then commences, becomes circadian, and reaches its highest nocturnal blood levels between the ages of one to three years. During the remainder of childhood, nocturnal peak levels drop progressively by 80%. In adults, these...

journal_title：Experimental gerontology

authors： Waldhauser F,Kovács J,Reiter E

更新日期：1998-11-01 00:00:00

abstract：:The effect of aging was tested on experimental ventricular arrhythmias in isolated heart preparations from normal Wistar rats (NWR), Wistar Kyoto rats (WKY), and spontaneously hypertensive rats (SHR). Delayed afterdepolarizations and triggered activity induced by high-calcium perfusion (16 mM) in isolated papillary mu...

journal_title：Experimental gerontology

authors： Carbonin PU,Di Gennaro M,Pahor M,Bernabei R,Sgadari A,Gambassi G Jr

更新日期：1990-01-01 00:00:00

abstract：:Ageing is a complex process that in muscle in usually associated with a decrease in mass, strength, and velocity of contraction. One of the most striking effects of ageing on muscle is known as sarcopenia, a process that is the result of many cellular changes, such as a reduction in the number of motor units coupled w...

journal_title：Experimental gerontology

authors： Fulle S,Protasi F,Di Tano G,Pietrangelo T,Beltramin A,Boncompagni S,Vecchiet L,Fanò G

更新日期：2004-01-01 00:00:00

abstract：:This article addresses the description of several endocrine-related functions of the brain. It has emerged that steroids and growth factors may influence brain functions, and that brain cells may metabolize sex steroids. The crosstalk between different types of brain cells (neurons, astrocytes, the LHRH (luteinizing h...

journal_title：Experimental gerontology

authors： Martini L,Melcangi RC

更新日期：1997-07-01 00:00:00

abstract：:Advances in our understanding of tau-mediated neurodegeneration in Alzheimer's disease (AD) are moving this disease pathway to center stage for the development of biomarkers and disease modifying drug discovery efforts. Immunoassays were developed detecting total (t-tau) and tau phosphorylated at specific epitopes (p-...

journal_title：Experimental gerontology

authors： Hampel H,Blennow K,Shaw LM,Hoessler YC,Zetterberg H,Trojanowski JQ

更新日期：2010-01-01 00:00:00

abstract：:Threat-related changes in postural control and their associations with changes in emotional and cognitive states are influenced by postural threat experience, however, limited work has explored individuals' capacity to adapt threat-related responses over longer periods of threat exposure. This study examined the effec...

journal_title：Experimental gerontology

authors： Johnson KJ,Zaback M,Tokuno CD,Carpenter MG,Adkin AL

更新日期：2019-07-15 00:00:00

abstract：:Evolutionary aspects of menopause are considered from several perspectives. First, the programmed exhaustion of ovarian oocytes appears to be a general trait of mammals that is not as widely found in other vertebrates. Second, studies on mice suggest that the maternal age effect that accelerates the incidence of Down ...

journal_title：Experimental gerontology

authors： Finch CE

更新日期：1994-05-01 00:00:00