Abstract:
:Forkhead box O 3a (FoxO3a) has been known to link with aging process and senescence. In this study, we investigated the age-related changes of FoxO3a in the gerbil hippocampus using immunohistochemistry and western blot analysis. In the postnatal month 3 (PM 3) group, FoxO3a immunoreactivity was well detected in pyramidal cells of the hippocampus proper, and granule cells of the dentate gyrus. FoxO3a immunoreactivity in the pyramidal cells of the hippocampus proper was not changed until PM 24. However, in the dentate granule cells, FoxO3a immunoreactivity was much decreased in the dorsal blade, not the ventral blade, of the granule cell layer in the PM 6 and 12 groups compared to the PM 3 group. At PM 24, FoxO3a immunoreactivity in the granule cells was hardly detected. Western blot analysis showed that FoxO3a level was significantly decreased in the PM 24 group. These results indicate that FoxO3a immunoreactivity and levels are markedly decreased in the dentate gyrus of the aged gerbil hippocampus.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Park JH,Lee CH,Yoo KY,Choi JH,Hwang IK,Lee JY,Kang IJ,Won MHdoi
10.1016/j.exger.2011.06.001subject
Has Abstractpub_date
2011-10-01 00:00:00pages
836-40issue
10eissn
0531-5565issn
1873-6815pii
S0531-5565(11)00144-6journal_volume
46pub_type
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