Fetal and placental growth in young, primiparous and old, multiparous rats.

Abstract:

:Fetal and placental weights and peripheral blood progestagen concentrations were examined on days 13, 16 and 22 of gestation in young (3-5 month) nulliparous and old (9-12 month) multiparous, albino Wistar rats. There was no difference in fetal weights at any stage examined whereas placental weights were significantly heavier in the old rats at days 16 (71%) and 22 (38%). Blood progesterone concentrations were similar in the two groups at days 16 and 22 although concentrations of the less biologically active progestagen, 20 alpha-dihydroprogesterone, were higher (61%) at day 16 in the old rats. The relative hypertrophy of the placentas in the old rats could not be explained by reduced litter size or progesterone concentrations: it may represent a compensatory effect in response to a less favorable uterine environment.

journal_name

Exp Gerontol

journal_title

Experimental gerontology

authors

Rahima A,Bruce NW

doi

10.1016/0531-5565(87)90004-0

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

257-61

issue

4

eissn

0531-5565

issn

1873-6815

pii

0531-5565(87)90004-0

journal_volume

22

pub_type

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