A light and electron microscope study of aging parotid and submandibular salivary glands of Swiss-Webster mice.


:Light and electron microscope comparisons were made of parotid and submandibular glands from male Swiss-Webster white mice 3, 13, and 18 months old. The glands from the 13- and 18-month-old mice were less organized and the parenchyma was not as dense. Fibrous connective tissue, intracellular lipofuscin granules, and residual body formation increased with age. In the cells of the parotid glands of 18-month-old mice, the nucleus-to-cytoplasm ratio was greater than in the specimens from the younger two ages. The granular convoluted tubules in submandibular glands of 18-month-old mice were the smallest of all age groups. The age changes appear comparable to those of rat and human salivary glands, yet this is an inexpensive animal model that achieves old age in less time than other animal models.


Exp Gerontol


Experimental gerontology


Meisel DL,Skobe Z,Prostak KS,Shklar G




Has Abstract


1988-01-01 00:00:00












  • Exercise training causes a partial improvement through increasing testosterone and eNOS for erectile function in middle-aged rats.

    abstract:PURPOSE:Aging changes the balance of sex hormones and causes endothelial dysfunction in the penis, both of which are important determinants of erectile dysfunction (ED). The purpose of this study was to evaluate whether exercise training could protect against erectile dysfunction by increasing serum testosterone and pe...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Seo DY,Lee SR,Kwak HB,Park H,Seo KW,Noh YH,Song KM,Ryu JK,Ko KS,Rhee BD,Han J

    更新日期:2018-07-15 00:00:00

  • The importance of inflammatory mechanisms for the development of Alzheimer's disease.

    abstract::A variety of inflammatory proteins has been identified in brains of patients with Alzheimer's disease. The current data suggest that the inflammatory processes are intimately involved in several crucial events in the pathological cascade. Immunohistochemical studies reveal that those parts of the brain wherein the amy...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Eikelenboom P,Veerhuis R

    更新日期:1999-06-01 00:00:00

  • Changes in circulating levels of neuroendocrine and thymic hormones during aging in rats: a correlation study.

    abstract::It is well established that during early life the thymus gland and the neuroendocrine system influence each other's maturation. Furthermore, there is a growing body of evidence indicating that the immune and neuroendocrine systems also function as a bidirectional network during adult life. In order to assess possible ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Goya RG,Naylor PH,Goldstein AL,Meites J

    更新日期:1990-01-01 00:00:00

  • Depletion of oxaloacetate decarboxylase FAHD1 inhibits mitochondrial electron transport and induces cellular senescence in human endothelial cells.

    abstract::In this study we report the identification of FAH domain containing protein 1 (FAHD1), a recently described member of the fumarylacetoacetate hydrolase (FAH) superfamily of metabolic enzymes, as a novel player in the regulation of cellular senescence. FAHD1 was found in a proteomic screen searching for mitochondrial p...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Petit M,Koziel R,Etemad S,Pircher H,Jansen-Dürr P

    更新日期:2017-06-01 00:00:00

  • Lifelong wheel running exercise and mild caloric restriction attenuate nuclear EndoG in the aging plantaris muscle.

    abstract::Apoptosis plays an important role in atrophy and sarcopenia in skeletal muscle. Recent evidence suggests that insufficient heat shock proteins (HSPs) may contribute to apoptosis and muscle wasting. In addition, long-term caloric restriction (CR) and lifelong wheel running exercise (WR) with CR provide significant prot...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Kim JH,Lee Y,Kwak HB,Lawler JM

    更新日期:2015-09-01 00:00:00

  • Cumulative 3-nitrotyrosine in specific muscle proteins is associated with muscle loss during aging.

    abstract::Post-translational oxidative protein modifications which are more marked during aging and/or high-calorie (HC) diets affect protein function and metabolism. Protein function and metabolism are different according to the type of muscle proteins. Oxidative muscle protein modifications may thus be associated with age-rel...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Murakami H,Guillet C,Tardif N,Salles J,Migné C,Boirie Y,Walrand S

    更新日期:2012-02-01 00:00:00

  • Vitamin D receptor gene polymorphisms in Alzheimer's disease patients.

    abstract:THE AIM:The aim of this study was to determine whether polymorphisms of the VDR gene may increase the risk of Alzheimer disease (AD) development in Lower Silesian patients in comparison with other populations. MATERIAL AND METHODS:108 AD patients (aged 73.7±8.6) vs 77 healthy volunteers (aged 64.5±7.8) in the Lower Si...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Łaczmański Ł,Jakubik M,Bednarek-Tupikowska G,Rymaszewska J,Słoka N,Lwow F

    更新日期:2015-09-01 00:00:00

  • Differential effects of transforming growth factor-beta 1 on the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in young and old human fibroblasts.

    abstract::The balance between the activities of matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases (TIMPs) is an important control point in tissue remodeling. Previous studies have demonstrated elevated expression of the MMPs collagenase and stromelysin-1 by aged human diploid fibroblasts compared ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Edwards DR,Leco KJ,Beaudry PP,Atadja PW,Veillette C,Riabowol KT

    更新日期:1996-01-01 00:00:00

  • Ovariectomy and 17beta-estradiol modulate the levels of Alzheimer's amyloid beta peptides in brain.

    abstract::Alzheimer's disease (AD) is a neurodegenerative disorder characterized by accumulation of aggregated forms of the 40- and 42-amino acid Abeta peptides (Abeta40 and Abeta42). Estrogen replacement therapy (ERT) in postmenopausal women is associated with decreased risk for AD and/or delay in disease onset. The mechanism ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Petanceska SS,Nagy V,Frail D,Gandy S

    更新日期:2000-12-01 00:00:00

  • CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.

    abstract:OBJECTIVE:Hippocampal sclerosis of aging (HS-Aging) is a common cause of dementia in older adults. We tested the variability in cerebrospinal fluid (CSF) proteins associated with previously identified HS-Aging risk single nucleotide polymorphisms (SNPs). METHODS:Alzheimer's Disease Neuroimaging Initiative cohort (ADNI...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Fardo DW,Katsumata Y,Kauwe JSK,Deming Y,Harari O,Cruchaga C,Alzheimer's Disease Neuroimaging Initiative.,Nelson PT

    更新日期:2017-04-01 00:00:00

  • Weakness, SR function and stress in gastrocnemius muscles of aged male rats.

    abstract::Aging is associated with a decline in muscle force that exceeds loss of muscle mass, suggesting that factors other than sarcopenia affect age-related muscle weakness. Here, we investigate in situ muscle force and sarcoplasmic reticulum (SR) properties in gastrocnemius muscles of adult (6-8 months) and aged (24 months)...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Russ DW,Wills AM,Boyd IM,Krause J

    更新日期:2014-02-01 00:00:00

  • Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training.

    abstract::Intrinsic exercise capacity is predictive of both lifespan and healthspan but whether adaptive exercise capacity influences the benefits achieved from aerobic training implemented later in life is not known. AIM:To determine if exercise late in life provides any functional improvements or underlying beneficial bioche...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Brown LA,Macpherson PC,Koch LG,Qi NR,Britton SL,Brooks SV

    更新日期:2019-10-01 00:00:00

  • SIRT1 expression in the cochlea and auditory cortex of a mouse model of age-related hearing loss.

    abstract::SIRT1 is a highly conserved NAD(+)-dependent protein deacetylase known to have protective effects against a variety of age-related diseases. However, there is a lack of information concerning SIRT1 expression in the cochlea and auditory cortex of C57BL/6 mice, a mouse model of age-related hearing loss. Using RT-PCR an...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Xiong H,Dai M,Ou Y,Pang J,Yang H,Huang Q,Chen S,Zhang Z,Xu Y,Cai Y,Liang M,Zhang X,Lai L,Zheng Y

    更新日期:2014-03-01 00:00:00

  • The impact of 2 weeks of detraining on phase angle, BIVA patterns, and muscle strength in trained older adults.

    abstract:BACKGROUND:An intermission in the training routine, in which older adults refrain from regular structured exercise, may have deleterious effects on muscle performance and bioelectric phase angle (PhA), which is a predictive marker for cellular integrity. PURPOSE:To determine the effects of a 2-week detraining period o...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Freitas SP,Júdice PB,Hetherington-Rauth M,Magalhães JP,Correia IR,Lopes JM,Strong C,Matos D,Sardinha LB

    更新日期:2021-02-01 00:00:00

  • Tissue-specificity of reactivity to concanavalin-A of human cells in culture.

    abstract::Concanavalin-A (Con-A) reactivity was studied to identify the tissue-specificity of cells established from various normal human tissues. Cells were treated with Con-A-labelled human red blood cells (C-RBC). C-RBC was not absorbed on the cells derived from the bone marrow, skin and liver. Lung-derived fibroblast cells ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Ban S,Iida S

    更新日期:1983-01-01 00:00:00

  • Grape seed proanthocyanidin lowers brain oxidative stress in adult and middle-aged rats.

    abstract::There is growing concern over the increasing instances of decline in cognitive abilities with aging in humans. The present study evaluated the benefits of the natural antioxidant, grape seed proanthocyanidin extract (GSPE) in treating the effects of age-related oxidative stress (OS) and accumulation of lipofuscin (LF)...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Asha Devi S,Sagar Chandrasekar BK,Manjula KR,Ishii N

    更新日期:2011-11-01 00:00:00

  • Age-related changes in melatonin levels in humans and its potential consequences for sleep disorders.

    abstract::Prior to three months of age there is little melatonin (MLT) secretion in humans. MLT production then commences, becomes circadian, and reaches its highest nocturnal blood levels between the ages of one to three years. During the remainder of childhood, nocturnal peak levels drop progressively by 80%. In adults, these...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Waldhauser F,Kovács J,Reiter E

    更新日期:1998-11-01 00:00:00

  • A busy day has minimal effect on factors associated with falls in older people: An ecological randomised crossover trial.

    abstract::Fatigue is a common complaint in older people. Laboratory-induced muscle fatigue has been found to affect physical functions in older populations but these protocols are rigorous and are unlikely to accurately reflect daily activities. This study used an ecological approach to determine the effects of a busy day on se...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,随机对照试验


    authors: Sturnieks DL,Yak SL,Ratanapongleka M,Lord SR,Menant JC

    更新日期:2018-06-01 00:00:00

  • Attenuated aortic blood pressure responses to metaboreflex activation in older adults with dynapenia.

    abstract:BACKGROUND:Low muscle strength (dynapenia) is a primary characteristic of sarcopenia, the age-related loss of muscle mass and strength or low walking speed. New evidence suggests that muscle strength positively affects blood pressure (BP) responses to exercise. As older adults with lowest handgrip strength also have lo...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Wong A,Jaime SJ,Grubbs B,Panton LB,Fischer SM,Figueroa A

    更新日期:2020-09-01 00:00:00

  • The contribution of reactive oxygen species to sarcopenia and muscle ageing.

    abstract::Ageing is a complex process that in muscle in usually associated with a decrease in mass, strength, and velocity of contraction. One of the most striking effects of ageing on muscle is known as sarcopenia, a process that is the result of many cellular changes, such as a reduction in the number of motor units coupled w...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Fulle S,Protasi F,Di Tano G,Pietrangelo T,Beltramin A,Boncompagni S,Vecchiet L,Fanò G

    更新日期:2004-01-01 00:00:00

  • Met-enkephalin modulates lipid peroxidation and total sialic acid level in CBA mice in age- and sex-dependent manners.

    abstract::Age- and sex-associated differences in lipid peroxidation (LPO), and total sialic acid content (TSA) in response to abuse of drugs have been reported both in humans and experimental animals. However, no data on the influence of gender and age on these parameters have been reported for methionine-enkephalin (MENK). In ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Sverko V,Sobocanec S,Balog T,Marotti T

    更新日期:2002-12-01 00:00:00

  • Betaine attenuates lysophosphatidylcholine-mediated adhesion molecules in aged rat aorta: modulation of the nuclear factor-κB pathway.

    abstract::We previously reported that lysophosphatidylcholine (LPC) is a mediator of endothelial dysfunction in the expression of adhesion molecules (AMs) during aging. This study aimed at investigating the effects of betaine on LPC-related expression of AMs and the molecular modulation of nuclear factor-κB (NF-κB) activation i...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Lee EK,Jang EJ,Jung KJ,Kim DH,Yu BP,Chung HY

    更新日期:2013-05-01 00:00:00

  • A biochemical study of optic nerve myelin isolated by a micromethod from different aged rats.

    abstract::A micromethod was used to study myelin from individual rat optic nerves as a function of age. Protein and galactolipid content as well as 2',3'-cyclic nucleotide phosphohydrolase (CNPase) activity at ages 2, 4, 22, and 28 months were determined. Protein content increased significantly at 22 months and decreased at adv...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Jacks AS,Richardson AR,Jones MA

    更新日期:1989-01-01 00:00:00

  • Association of serum uric acid with body mass index among long-lived Chinese.

    abstract:OBJECTIVES:To examine the individual association between BMI and level of serum uric acid (SUA) among the very elderly Chinese population. METHODS:A survey was conducted on 870 long-lived subjects (aged ≥90years). Subjects were divided into four groups according to quartile of BMI (<16.6, 16.6-18.9, 18.9-21.1, ≥21.1kg...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Yue JR,Huang CQ,Dong BR

    更新日期:2012-08-01 00:00:00

  • Effect of 2-mercaptoethylamine on proliferation and lifespan of WI-38 cells.

    abstract::The antioxidant 2-mercaptoethylamine (MEA) was added to the culture medium of WI-38 cells throughout their lifespan. MEA concentrations of 0.5 microM, 5 microM and 50 microM were used. The presence of 5 microM or 50 microM MEA decreased the fraction of rapidly dividing cells and slightly reduced cell density at conflu...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Golczewski JA

    更新日期:1984-01-01 00:00:00

  • Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system: microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb.

    abstract::Neuroinflammation may play a role in the pathogenesis of Parkinson's disease (PD). The present study questioned whether this neuroinflammatory response differs between the olfactory bulb, as an early affected region and the nigrostriatal system. Indeed, increased microgliosis was shown in post-mortem olfactory bulb of...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Vroon A,Drukarch B,Bol JG,Cras P,Brevé JJ,Allan SM,Relton JK,Hoogland PV,Van Dam AM

    更新日期:2007-08-01 00:00:00

  • Renal function in familial longevity: the Leiden Longevity Study.

    abstract::Studying renal function in subjects with a familial propensity for longevity may provide insight in (un)known mechanisms that determine the age-related decline in renal function of normal subjects. In the Leiden Longevity Study, middle-aged offspring of non-agenarian siblings and their partners as environmentally matc...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: de Goeij MC,Halbesma N,Dekker FW,Wijsman CA,van Heemst D,Maier AB,Mooijaart SP,Slagboom PE,Westendorp RG,de Craen AJ

    更新日期:2014-03-01 00:00:00

  • In vitro model of chronological aging of adipocytes: Interrelationships with hypoxia and oxidation.

    abstract::Aging is a physiological process characterized by an age-progressive decline in intrinsic physiological functions, with an increased risk of developing chronic metabolic conditions, such as insulin resistance and diabetes. Furthermore, from a physiopathological point of view, several authors describe an association be...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Zoico E,Rizzatti V,Policastro G,Tebon M,Darra E,Rossi AP,Mazzali G,Fantin F,Zamboni M

    更新日期:2019-07-01 00:00:00

  • Is turtle longevity linked to enhanced mechanisms for surviving brain anoxia and reoxygenation?

    abstract::We suggest that the processes that protect the turtle brain against anoxia and subsequent reoxygenation might also contribute to turtle longevity since many of them are linked to age related neurodegeneration. In the turtle the mechanisms for conserving ion channel function are particularly robust. The anoxic turtle b...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Lutz PL,Prentice HM,Milton SL

    更新日期:2003-07-01 00:00:00

  • Role of advanced glycation end products (AGEs) and receptor for AGEs (RAGE) in vascular damage in diabetes.

    abstract::A non-enzymatic reaction between ketones or aldehydes and the amino groups of proteins, lipids and nucleic acids contributes to the aging of macromolecules and to the development and progression of various age-related disorders such as vascular complications of diabetes, Alzheimer's disease, cancer growth and metastas...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Yamagishi S

    更新日期:2011-04-01 00:00:00