Telomerase, mitochondria and oxidative stress.

abstract：:The elderly exhibit reduced responses to vaccinations, leaving them more susceptible to preventable infectious diseases such as influenza and pneumonia. It has been unclear as to the specific changes in the aging immune system that contribute to this decline, thus we have developed a mouse model to examine this phenom...

journal_title：Experimental gerontology

authors： Haynes L

更新日期：2007-05-01 00:00:00

abstract：:The antioxidant 2-mercaptoethylamine (MEA) was added to the culture medium of WI-38 cells throughout their lifespan. MEA concentrations of 0.5 microM, 5 microM and 50 microM were used. The presence of 5 microM or 50 microM MEA decreased the fraction of rapidly dividing cells and slightly reduced cell density at conflu...

journal_title：Experimental gerontology

authors： Golczewski JA

更新日期：1984-01-01 00:00:00

abstract：:It has been suggested that alterations in Na(+),K(+)-ATPase mediate the development of several aging-related pathologies, such as hypertension and diabetes. Thus, we evaluated Na(+),K(+)-ATPase function and H(2)O(2) production in the renal cortex and medulla of Wistar Kyoto (WKY) rats at 13, 52 and 91 weeks of age. Cr...

journal_title：Experimental gerontology

authors： Silva E,Pinto V,Simão S,Serrão MP,Afonso J,Amaral J,Pinho MJ,Gomes P,Soares-da-Silva P

更新日期：2010-12-01 00:00:00

abstract：:Caloric restriction (CR) without malnutrition in mice and rats reduces the incidence of spontaneous tumors and delays their appearance while increasing maximum life span. These results depend largely on CR per se, and not on low intakes of fat or other nutrients. Although most studies have tested CR imposed early in l...

journal_title：Experimental gerontology

authors： Weindruch R

更新日期：1992-09-01 00:00:00

abstract：BACKGROUNDS:Elucidating the causal effects of common intermediate risk factors on the onset of age-related diseases is indispensable for developing prevention and intervention procedures. METHODS:We conducted two-stage time-to-event Mendelian randomization meta-analyses combining five large-scale longitudinal cohorts ...

journal_title：Experimental gerontology

authors： He L,Culminskaya I,Loika Y,Arbeev KG,Bagley O,Duan M,Yashin AI,Kulminski AM

更新日期：2018-07-01 00:00:00

abstract：:There is growing concern over the increasing use of opioids to treat chronic pain in the elderly primarily because of the potential increased sensitivity to the adverse side effects. Here, we use a preclinical model (male Brown Norway X F344 rats aged 12, 18, 24, and 30 months) to describe the outcome of chronic fenta...

journal_title：Experimental gerontology

authors： Mitzelfelt JD,Dupree JP,Seo DO,Carter CS,Morgan D

更新日期：2011-01-01 00:00:00

abstract：:In the central nervous system, the degree of decline in memory retrieval along the aging process depends on the quantity and quality of the stimuli received during lifetime. The cholinergic system modulates long-term potentiation and, therefore, memory processing. This study evaluated the spatial memory, the synaptic ...

journal_title：Experimental gerontology

authors： Baraldi T,Schöwe NM,Balthazar J,Monteiro-Silva KC,Albuquerque MS,Buck HS,Viel TA

更新日期：2013-08-01 00:00:00

abstract：:Histological surveys of the hearts of guppies Poecilia reticulatus throughout their lifespan showed no aging changes until the fish were three years old. In younger fishes the hearts were healthy, even in three individuals with "wasting" disease, where there was considerable loss of muscle throughout the body. There w...

journal_title：Experimental gerontology

authors： Woodhead AD

更新日期：1984-01-01 00:00:00

abstract：:Melatonin, the main product synthesized by the pineal gland, modulates several brain functions through different mechanisms, some of them involving the activation or participation of calcium binding intracellular proteins, such as the alpha calcium dependent protein kinase C and calmodulin. Another calcium-binding pro...

journal_title：Experimental gerontology

authors： Ramírez-Rodríguez G,Gómez-Sánchez A,Ortíz-López L

更新日期：2014-12-01 00:00:00

abstract：:The age-associated decline in the regenerative abilities of mesenchymal stem cells (MSCs) may be due to age-related changes in reduction in number, intrinsic properties of MSCs and extrinsic factors of the extracellular environment (the stem cell niche). The effect of age on the efficacy of MSC transplantation on rege...

journal_title：Experimental gerontology

authors： Iohara K,Murakami M,Nakata K,Nakashima M

更新日期：2014-04-01 00:00:00

abstract：:Young and old C57BL/6 male mice were given a diet containing a high dose of vitamin E (VE treatment) and its effect on the immune system was examined before and after the exposure to restraint stress. The VE treatment per se gave rise to a slight increase of splenic T cells in percentage and a significant enhancement ...

journal_title：Experimental gerontology

authors： Wakikawa A,Utsuyama M,Wakabayashi A,Kitagawa M,Hirokawa K

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:The elderly lose skeletal muscle mass with age, which may be detrimental for function and quality of life. Both inactivity and heavy resistance exercise are known to have marked but opposite effects upon muscle mass. However, the potential effects of daily physical activity upon muscle protein synthesis (MPS) a...

journal_title：Experimental gerontology

authors： Bülow J,Agergaard J,Kjaer M,Holm L,Reitelseder S

更新日期：2016-06-15 00:00:00

abstract：:In this study, spontaneous multiple unit activity (MUA, action potentials derived simultaneously from a number of neurons in a given brain region) was recorded through electrodes chronically implanted in the parietal cerebral cortex of the rats of 1, 3, 6, 9, 12, and 26 months of age (cross-sectional study). Electroph...

journal_title：Experimental gerontology

authors： Roy D,Singh R

更新日期：1988-01-01 00:00:00

abstract：:The effect of 3-(4-pyridyl)-1,2,4-thiotriazolyl 5-mercaptoacetic acid kalium salt (Rumosol) and 3-(4-pyridyl)-1,2,4-thiotriazolyl 5-mercaptoacetic acid morpholinium salt (drug 2) on the concentration of Schiff base in myocardium of adult (10-12 months) and old (22-25 months) Wistar rats during immobilized stress were ...

journal_title：Experimental gerontology

authors： Davydov VV,Shvets VN

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Critically ill intensive care patients are subjected to controlled mechanical ventilation (CMV) which has an important association in triggering the impaired muscle function and the consequent delayed weaning from the respirator. AIM:The main aim of this study was to measure the effects of age and CMV over ...

journal_title：Experimental gerontology

authors： Cacciani N,Ogilvie H,Larsson L

更新日期：2014-11-01 00:00:00

abstract：:The age-dependent modifications of both basal and lymphokine-induced natural killer (NK) activity were analyzed in Balb/c inbred mice by measuring either the percentage of specific lytic activity in a 51 Cr release assay or the percentage of cells capable of binding the YAC-1 target cells. The basal lytic activity of ...

journal_title：Experimental gerontology

authors： Provinciali M,Muzzioli M,Fabris N

更新日期：1989-01-01 00:00:00

abstract：:Age-related changes in cancer mortality risk are important for understanding the processes of disease and aging interaction. The extent to which these age changes differ by sex further contributes to this understanding but has not been well studied to date. We conducted a systematic examination of dynamics and heterog...

journal_title：Experimental gerontology

authors： Yang Y,Li T,Nielsen ME

更新日期：2012-09-01 00:00:00

abstract：:Long-lived recombinant inbred lines, some of which have mean and maximum life spans up to 70% longer than wild type, were used in these analyses. Longer life results from a slower exponential rate of increase in mortality. General motor activity decreases with chronological age in all genotypes; this decay in general ...

journal_title：Experimental gerontology

authors： Johnson TE,Conley WL,Keller ML

更新日期：1988-01-01 00:00:00

abstract：:With many caveats to the traditional vertebrate species pertaining to biogerontology investigations, it has been suggested that a most informative model is the one which: 1) examines closely related species, or various members of the same species with naturally occurring lifespan variation, 2) already has adequate med...

journal_title：Experimental gerontology

authors： Gilmore KM,Greer KA

更新日期：2015-11-01 00:00:00

abstract：:Muscle wasting diseases are gradually increasing with the increase in global life expectancy. This study was designed to evaluate the efficacy of HIM-CHX, a herbal combination of Boswellia serrata, Cissus quadrangularis, and Withania somnifera, on Sarcopenia. The effects of HIM-CHX on parameters such as muscle mass, g...

journal_title：Experimental gerontology

authors： Azeemuddin MM,Rao CM,Rafiq M,Babu UV,Rangesh P

更新日期：2019-10-01 00:00:00

abstract：:The maximal lifespan (MLS) of mammals is inversely correlated with the peroxidation index, a measure of the proportion and level of unsaturation of polyunsaturated fatty acids (PUFA) in membranes. This relationship is likely related to the fact that PUFA are highly susceptible to damage by peroxidation. Previous compa...

journal_title：Experimental gerontology

authors： Cortie CH,Hulbert AJ,Hancock SE,Mitchell TW,McAndrew D,Else PL

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVES:To investigate whether the implementation of a multifactorial falls intervention in nursing homes is cost-beneficial and alleviates the professional workload. DESIGN:A comprehensive quantitative model was developed to calculate the impact of investments in multifactorial falls prevention in nursing homes in...

journal_title：Experimental gerontology

authors： Panneman MJM,Sterke CS,Eilering MJ,Blatter BM,Polinder S,Van Beeck EF

更新日期：2021-01-01 00:00:00

abstract：:Studying the changes of serum N-glycome during mouse aging is beneficial to explore the molecular basis behind the alterations reported in human. However, such studies remainscarce and lack some information such as sialylation due to the method limitation. Here, we introduced Bionic Glycome method to quantify the seru...

journal_title：Experimental gerontology

authors： Han J,Pan Y,Qin W,Gu Y,Xu X,Zhao R,Sha J,Zhang R,Gu J,Ren S

更新日期：2020-11-01 00:00:00

abstract：:Histopathological and autofluorescence investigations were carried out to study lipofuscin pigment accumulation in various age groups of mice. Qualitative studies revealed an increase of lipofuscin pigment accumulation in old animals. Quantitative studies showed a significant increase in the percentage of pigmented ne...

journal_title：Experimental gerontology

authors： Goyal VK

更新日期：1982-01-01 00:00:00

abstract：:As recently reported, it is possible to detect and quantify the amount of the deleted human mitochondrial DNA (mtDNA) in whole blood, platelets and peripheral blood mononuclear cells using real-time PCR. The aim of this study was to identify the cell types in human blood carrying the 4977 bp deleted mtDNA and their ac...

journal_title：Experimental gerontology

authors： Mohamed SA,Wesch D,Blumenthal A,Bruse P,Windler K,Ernst M,Kabelitz D,Oehmichen M,Meissner C

更新日期：2004-02-01 00:00:00

abstract：:Accumulation of myeloid-derived suppressor cells (MDSCs) in aged hosts contribute to the age-related increase of susceptibility to murine breast adenocarcinoma and co-stimulatory molecules expressed in MDSCs are essential for MDSCs-mediated immune suppression. However, the co-stimulatory molecules that exert a direct ...

journal_title：Experimental gerontology

authors： Chen S,Liu H,Su N,Zhang G,Wang L

更新日期：2015-01-01 00:00:00

abstract：:The slow and continuous loss of muscle mass that progresses with aging is defined as "sarcopenia". Sarcopenia represents an important public health problem, being closely linked to a condition of frailty and, therefore, of disability. According to the European Working Group on Sarcopenia in Older People, the diagnosis...

journal_title：Experimental gerontology

authors： Curcio F,Ferro G,Basile C,Liguori I,Parrella P,Pirozzi F,Della-Morte D,Gargiulo G,Testa G,Tocchetti CG,Bonaduce D,Abete P

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the effects of 12 weeks of traditional resistance training (TRT) or resistance training using Cluster-set (CS) on functional performance and physical fitness of postmenopausal and elderly women. METHODS:Participants (61.1 ± 4.9 years, body mass 64.5 ± 1.8 kg, height 155.7...

journal_title：Experimental gerontology

authors： Dias RKN,Penna EM,Noronha ASN,de Azevedo ABC,Barbalho M,Gentil PV,Coswig VS

更新日期：2020-09-01 00:00:00

abstract：:A longitudinal study was performed to confirm the inverse relationship between in vivo age and in vitro proliferative capacity previously observed in a cross-sectional study, and to investigate the relationship between the growth of dermal fibroblasts in vitro and a physiological function (i.e., wound repair) that is ...

journal_title：Experimental gerontology

authors： Bruce SA,Deamond SF

更新日期：1991-01-01 00:00:00

abstract：:Understanding telomere biology is of utmost importance for aging and cancer research. An essential tool is the determination of telomere length, which traditionally is done by telomere restriction fragment analysis, a laborious and time consuming method. Therefore, large efforts have been made to establish alternative...

journal_title：Experimental gerontology

authors： Wieser M,Stadler G,Böhm E,Borth N,Katinger H,Grillari J,Voglauer R

更新日期：2006-02-01 00:00:00