Lipofuscin pigment accumulation in the central nervous system of the mouse during aging.

abstract：:In order to clarify immunogenetic markers contributing to successful aging, HLA and cytokine gene profiles were analyzed in healthy elderly Bulgarians. Family segregation analysis was performed to define combined effect of haplotypes and immunophenotype profiles. The results of this study did not reveal any statistica...

journal_title：Experimental gerontology

authors： Naumova E,Mihaylova A,Ivanova M,Michailova S,Penkova K,Baltadjieva D

更新日期：2004-04-01 00:00:00

abstract：:Alzheimer's disease is one of the most devastating neurodegenerative diseases. The exact cause of the disease is still not known although many scientists believe in the beta amyloid hypothesis which states that the accumulation of the amyloid peptide beta (Aβ) in brain is the initial cause which consequently leads to ...

journal_title：Experimental gerontology

authors： Le Page A,Dupuis G,Frost EH,Larbi A,Pawelec G,Witkowski JM,Fulop T

更新日期：2018-07-01 00:00:00

abstract：:Forkhead box O 3a (FoxO3a) has been known to link with aging process and senescence. In this study, we investigated the age-related changes of FoxO3a in the gerbil hippocampus using immunohistochemistry and western blot analysis. In the postnatal month 3 (PM 3) group, FoxO3a immunoreactivity was well detected in pyram...

journal_title：Experimental gerontology

authors： Park JH,Lee CH,Yoo KY,Choi JH,Hwang IK,Lee JY,Kang IJ,Won MH

更新日期：2011-10-01 00:00:00

abstract：:We have developed a simian virus 40 (SV40) T-antigen immortalized human cell line, 1MR90-D305.2H4 (IDH4), in which the expression of T-antigen is controlled by the mouse mammary tumor virus (MMTV) promoter and thus regulated by steroids such as dexamethasone. Studies on the regulation of proliferation by T-antigen led...

journal_title：Experimental gerontology

authors： Shay JW,West MD,Wright WE

更新日期：1992-09-01 00:00:00

abstract：:The leucine-rich repeat transmembrane 3 (LRRTM3) has been defined as a positional and functional candidate gene for Alzheimer's disease. Recently, four novel variants (rs16923760, rs1925608, rs1925609 and rs10997477) within LRRTM3 were reported to be associated with late-onset Alzheimer's disease (LOAD) in Caucasians....

journal_title：Experimental gerontology

authors： Wang J,Yu JT,Jiang T,Tan MS,Wang HF,Tan L,Hu N,Sun L,Zhang W,Tan L

更新日期：2014-04-01 00:00:00

abstract：:In the central nervous system, the degree of decline in memory retrieval along the aging process depends on the quantity and quality of the stimuli received during lifetime. The cholinergic system modulates long-term potentiation and, therefore, memory processing. This study evaluated the spatial memory, the synaptic ...

journal_title：Experimental gerontology

authors： Baraldi T,Schöwe NM,Balthazar J,Monteiro-Silva KC,Albuquerque MS,Buck HS,Viel TA

更新日期：2013-08-01 00:00:00

abstract：:Mitochondrial superoxide production is an important source of reactive oxygen species in cells, and may cause or contribute to ageing and the diseases of ageing. Seven major sites of superoxide production in mammalian mitochondria are known and widely accepted. In descending order of maximum capacity they are the ubiq...

journal_title：Experimental gerontology

authors： Brand MD

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Sarcopenic obesity is a combination of both sarcopenia and obesity, which potentiate each other and maximize the negative influences of each, such as physical disability, morbidity, or even mortality. OBJECTIVES:To describe the criteria used to identify people with sarcopenic obesity and the components of t...

journal_title：Experimental gerontology

authors： Yin YH,Liu JYW,Välimäki M

更新日期：2020-07-01 00:00:00

abstract：:The Tokyo Metropolitan Institute of Gerontology (TMIG) celebrates its 30th anniversary in 2002. Since its establishment, TMIG has been carrying out inter-disciplinary research on aging as a core institute in Japan and functions as a knowledge bank and a source for capable researchers of gerontology. The proportion of ...

journal_title：Experimental gerontology

authors： Suzuki K

更新日期：2002-12-01 00:00:00

abstract：:Studies have suggested that older individuals are more fatigable than young adults when power loss, measured during single-joint contractions, is considered the fatigue index; however, age-related differences in fatigue considering power measurements during multi-joint movements (e.g., cycling) have not been fully elu...

journal_title：Experimental gerontology

authors： Krüger RL,Aboodarda SJ,Jaimes LM,Vaz MA,Samozino P,Millet GY

更新日期：2020-05-01 00:00:00

abstract：:Aging plays an important role in increased vulnerability to atrial fibrillation (AF). Mediated by activity at the muscarinic type 2 receptor (M2R), the parasympathetic nerve contributes to the onset of AF. The purpose of this study was to investigate whether aging changes the distribution of M2R in the atrial myocardi...

journal_title：Experimental gerontology

authors： Yang YH,Zheng QS,Li J,Shang FJ,Liu T,Wang HT,Liu XT,Liu L

更新日期：2009-09-01 00:00:00

abstract：:A series of theoretical analyses of mortality were performed on recent data for Mediterranean fruit flies (Ceratitus capitata). Best fit computations were performed using the Marquardt-Levenburg technique on: 1) the classic Gompertz model, 2) the Johnson-Mehl-Avrami (JMA) model from chemical kinetics theory, which is ...

journal_title：Experimental gerontology

authors： Hirsh AG,Williams RJ,Mehl P

更新日期：1994-03-01 00:00:00

abstract：:The correlation between serum levels of pituitary and thyroid hormones and the activity of two antioxidant enzymes (AOE), catalase (CAT) and superoxide dismutase (SOD), in different immune and nonimmune organs of young and old rats was investigated. Serum levels of growth hormone (GH), prolactin (Prl), thyroid-stimula...

journal_title：Experimental gerontology

authors： Bolzán AD,Brown OA,Goya RG,Bianchi MS

更新日期：1995-03-01 00:00:00

abstract：:Concanavalin-A (Con-A) reactivity was studied to identify the tissue-specificity of cells established from various normal human tissues. Cells were treated with Con-A-labelled human red blood cells (C-RBC). C-RBC was not absorbed on the cells derived from the bone marrow, skin and liver. Lung-derived fibroblast cells ...

journal_title：Experimental gerontology

authors： Ban S,Iida S

更新日期：1983-01-01 00:00:00

abstract：:Average life expectancy at birth is a rough measure of the span of healthy, productive life--the functional life span. In the developed countries average life expectancies at birth now range from 76-79 years, six to nine years less than the limit of about 85 years imposed by aging. Aging is the accumulation of changes...

journal_title：Experimental gerontology

authors： Harman D

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVES:To examine the individual association between BMI and level of serum uric acid (SUA) among the very elderly Chinese population. METHODS:A survey was conducted on 870 long-lived subjects (aged ≥90years). Subjects were divided into four groups according to quartile of BMI (<16.6, 16.6-18.9, 18.9-21.1, ≥21.1kg...

journal_title：Experimental gerontology

authors： Yue JR,Huang CQ,Dong BR

更新日期：2012-08-01 00:00:00

abstract：:Aging is characterized by the progressive decline in mass and function of the skeletal muscle along with increased susceptibility to inflammation, oxidative stress, and atrophy. In this study, we investigate the effect of intermittent bout and single bout exercise training on inflammatory molecules in young (3 months)...

journal_title：Experimental gerontology

authors： Kim JS,Yi HK

更新日期：2015-12-01 00:00:00

abstract：:Changes associated with the age-related decline of physiological functions, and their relation with mortality rates, are thoroughly being investigated in the aging research field. We used the Mediterranean fruit fly Ceratitis capitata, largely studied by biodemographers, as a model for functional senescence studies. T...

journal_title：Experimental gerontology

authors： Pujol-Lereis LM,Rabossi A,Quesada-Allué LA

更新日期：2012-06-01 00:00:00

abstract：:We investigated the effects of angiotensin-converting enzyme (ACE) inhibition and aerobic physical training on the heart of old female rats (82-wk-old) submitted to premature ovarian failure (10-wk.-old). We used different approaches: morphology and function by echocardiography, reactivity of the coronary bed and left...

journal_title：Experimental gerontology

authors： Felix ACS,Dutra SGV,Gastaldi AC,Bonfim PC,Vieira S,de Souza HCD

更新日期：2018-08-01 00:00:00

abstract：:Age-related behavioral declines are common manifestations of aging in animals. Negative geotaxis, an innate escape response during which flies ascend the wall of a cylinder after being tapped to its bottom, is one of the behaviors that senesces in Drosophila. Many laboratories, including ours, have used a variety of n...

journal_title：Experimental gerontology

authors： Gargano JW,Martin I,Bhandari P,Grotewiel MS

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVES:The present study investigated whether the performance on executive function tasks of patients with type 2 diabetes mellitus (T2DM) is as impaired as that of Alzheimer's disease (AD) patients and to compare their performance with that of a group of cognitively healthy older adults. We also investigated wheth...

journal_title：Experimental gerontology

authors： Redondo MT,Beltrán-Brotóns JL,Reales JM,Ballesteros S

更新日期：2016-10-01 00:00:00

abstract：:The gangliosides in human diploid fibroblasts--TIG-1, TIG-7, and IMR-90--were analysed at different cell densities at early and late passages to clarify the relationship between age and cell density dependent changes of the gangliosides. In early passages, the ganglioside concentrations increased with increase in cell...

journal_title：Experimental gerontology

authors： Ohsawa T

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Self-report questionnaires are widely used to assess physical function in older adults. However, they often lack a clear frame of reference and hence interpreting and rating task difficulty levels can be problematic for the responder. Consequently, the usefulness of traditional self-report questionnaires for...

journal_title：Experimental gerontology

authors： Balachandran A,N Verduin C,Potiaumpai M,Ni M,Signorile JF

更新日期：2016-08-01 00:00:00

abstract：:Connexin 43 (Cx43) is the constitutive protein for the formation of cardiac gap junctions and therefore essential for cell-cell coupling and normal cardiac function. Apart from its localization at the sarcolemma, Cx43 is present in the inner mitochondrial membrane. Cx43 is involved in cardiomyocyte free oxygen radical...

journal_title：Experimental gerontology

authors： Boengler K,Heusch G,Schulz R

更新日期：2006-05-01 00:00:00

abstract：:The purpose of this study was to examine the relative contributions of changes in muscle quality and body composition to changes in lower-extremity physical function (LEPF) following a 6-month exercise and weight loss intervention in overweight and obese older women. Thirty-eight overweight and obese (BMI = 30.0 ± 4.4...

journal_title：Experimental gerontology

authors： Straight CR,Berg AC,Reed RA,Johnson MA,Evans EM

更新日期：2018-07-15 00:00:00

abstract：:The visual appearance of humans derives predominantly from their skin and hair color. The phylogenetically ancient biochemical [corrected] pathway underling this phenomenon is called melanogenesis and results in the production of melanin pigments in neural crest-derived melanocytes, followed by its transfer to epithel...

journal_title：Experimental gerontology

authors： Tobin DJ,Paus R

更新日期：2001-01-01 00:00:00

abstract：:Measuring physiological dysregulation during aging could be a key tool both to understand underlying aging mechanisms and to predict clinical outcomes in patients. However, most existing indices are either circular or hard to interpret biologically. Recently, we showed that statistical distance of 14 common blood biom...

journal_title：Experimental gerontology

authors： Cohen AA,Milot E,Li Q,Legault V,Fried LP,Ferrucci L

更新日期：2014-09-01 00:00:00

abstract：:To study the several elements and causes of ageing, diverse model organisms and methodologies are required. The most frequently used models are Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster and rodents. All have their advantages and disadvantages and allow studying particular aspects of the...

journal_title：Experimental gerontology

authors： Mouton S,Willems M,Braeckman BP,Egger B,Ladurner P,Schärer L,Borgonie G

更新日期：2009-04-01 00:00:00

abstract：:A summary of the Eleventh International Symposium on the Neurobiology and Neuroendocrinology of Aging that was held in July 29-August 3 in Bregenz, Austria, is presented. Sixteen of the speakers who presented at the conference submitted review papers covering the topic of their presentation as well as an overview of t...

journal_title：Experimental gerontology

authors： Brown-Borg HM,Borg KE

更新日期：2013-07-01 00:00:00

abstract：:Adult Premature Aging Mice (PAM) show premature immunosenescence, oxidative and inflammatory stress and consequently a shorter lifespan than Exceptional Non-Prematurely Aging Mice (E-NPAM) at the same age. Indeed, adult female PAM exhibit behavioral age-related declines and abnormalities in its brain neurochemistry. N...

journal_title：Experimental gerontology

authors： Garrido A,De La Serna M,De La Fuente M,Marco EM,López-Gallardo M

更新日期：2020-12-31 00:00:00