Abstract:
:The leucine-rich repeat transmembrane 3 (LRRTM3) has been defined as a positional and functional candidate gene for Alzheimer's disease. Recently, four novel variants (rs16923760, rs1925608, rs1925609 and rs10997477) within LRRTM3 were reported to be associated with late-onset Alzheimer's disease (LOAD) in Caucasians. To evaluate the association of the LRRTM3 polymorphisms with LOAD in Asians, we performed a case-control study of 2287 unrelated subjects (1129 cases and 1158 age- and gender-matched controls) in Han Chinese. The rs10997477 T allele was significantly associated with a decreased risk of LOAD in APOE ε4 allele noncarriers (OR=0.750, PC<0.001). Besides, the rs16923760 C allele significantly increased the risk of LOAD in APOE ε4 allele carriers (OR=1.837, PC<0.001). The genotype distribution of rs1925609 polymorphism also significantly differed in APOE ε4 allele noncarriers (PC=0.008). Moreover, the association was further demonstrated in multivariate logistic regression analysis (rs10997477: Recessive model: OR=0.156, PC=0.004; Additive model: OR=0.731, PC<0.001; rs16923760: Dominant model: OR=1.944, PC=0.024; Additive model: OR=1.885, PC<0.001; Recessive model: OR=3.565, PC=0.010; rs1925609: Recessive model: OR=0.421, PC=0.024). As for rs1925608, we failed to detect any association with LOAD. This study firstly provides the independent evidence that the LRRTM3 polymorphisms may play a role in the pathogenesis of LOAD in a Northern Han Chinese population. However, additional independent replication groups are required to further validate this association.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Wang J,Yu JT,Jiang T,Tan MS,Wang HF,Tan L,Hu N,Sun L,Zhang W,Tan Ldoi
10.1016/j.exger.2014.01.013subject
Has Abstractpub_date
2014-04-01 00:00:00pages
18-22eissn
0531-5565issn
1873-6815pii
S0531-5565(14)00025-4journal_volume
52pub_type
杂志文章abstract:BACKGROUND/OBJECTIVES:To explore the impact of diabetic peripheral neuropathy (DPN) on the recovery of older persons with diabetes mellitus (DM) after hip-fracture surgery. DESIGN, SETTING, PARTICIPANTS:Secondary data for this study came from a clinical trial on the effectiveness of a DM-specific care model for 176 ol...
journal_title:Experimental gerontology
pub_type: 临床试验,杂志文章
doi:10.1016/j.exger.2019.02.004
更新日期:2019-05-01 00:00:00
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更新日期:2011-09-01 00:00:00
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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doi:10.1016/j.exger.2015.06.003
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pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2003.10.011
更新日期:2004-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(82)90043-2
更新日期:1982-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2006.09.003
更新日期:2007-03-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2008.09.010
更新日期:2008-12-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(95)00014-3
更新日期:1995-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.exger.2003.10.031
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pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.11.013
更新日期:2015-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
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更新日期:2004-10-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(01)00229-7
更新日期:2002-05-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2005.07.006
更新日期:2005-12-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.05.055
更新日期:2013-08-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(88)90020-4
更新日期:1988-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2007.06.013
更新日期:2008-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-09-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,多中心研究
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更新日期:2015-10-01 00:00:00