Abstract：
:Concanavalin-A (Con-A) reactivity was studied to identify the tissue-specificity of cells established from various normal human tissues. Cells were treated with Con-A-labelled human red blood cells (C-RBC). C-RBC was not absorbed on the cells derived from the bone marrow, skin and liver. Lung-derived fibroblast cells showed weak C-RBC adsorption. Kidney-derived cells showed epithelial morphology and easily adsorbed C-RBC. These suggest that a large number of Con-A receptors exists on the membrane surface of kidney cells.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Ban S,Iida Sdoi
10.1016/0531-5565(83)90040-2subject
Has Abstractpub_date
1983-01-01 00:00:00pages
293-301issue
4eissn
0531-5565issn
1873-6815pii
0531-5565(83)90040-2journal_volume
18pub_type
杂志文章abstract：:Several studies have shown that centenarians have better cardiovascular risk profiles compared to younger old people. Some reports have revealed that cardiovascular diseases (i.e. hypertension, diabetes, angina and/or myocardial infarction) are less common in centenarians respect to 70 and 80 years old persons. In ord...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2007.06.009
更新日期：2008-02-01 00:00:00
abstract：:Long-term caloric restriction (CR) has been shown to extend maximum life span in laboratory rodents. We investigated the activities of gluconeogenic and transaminase enzymes in the livers of old and young mice fed either control or calorie-restricted diets. Livers were sampled 48 h after the last scheduled feeding tim...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(02)00202-4
更新日期：2003-03-01 00:00:00
abstract：:The mechanisms responsible for age-associated hearing loss are still incompletely characterized. In this study, we used a murine model of age-dependent hearing loss and evaluated whether this condition is associated with vascular modifications of the structures of the inner ear. We used old C57BL/6J mice that are affe...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.06.003
更新日期：2004-08-01 00:00:00
abstract：:Apolipoprotein E knockout (apoE-KO) mice have been utilized for decades as a model of atherosclerosis. However, in addition to atherosclerosis, apoE-KO mice develop extensive cutaneous xanthomatosis, accelerated skin aging and frailty when fed a high fat diet. Granzyme B (GrB) is a pro-apoptotic serine protease that h...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2011.02.004
更新日期：2011-06-01 00:00:00
abstract：:The aim of this study was to compare the functional and structural changes in similarly identified neurons of the small parietal ganglion in 56 molluscs (Lymnaea stagnalis) of two age groups: adult (10-12 months) and old (20-22 months). No age changes were found in the values of membrane potential, resistance of the n...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(95)00008-5
更新日期：1995-09-01 00:00:00
abstract：:Aging is associated with a change in membrane composition that includes a decrease in membrane polyunsaturated fatty acids, including arachidonic acid, and an increase in membrane cholesterol. Alterations in membrane structure are likely to impact on transmitter release, which relies on the fusion of synaptic plasma a...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(97)00130-7
更新日期：1998-06-01 00:00:00
abstract：:Age- and sex-associated differences in lipid peroxidation (LPO), and total sialic acid content (TSA) in response to abuse of drugs have been reported both in humans and experimental animals. However, no data on the influence of gender and age on these parameters have been reported for methionine-enkephalin (MENK). In ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(02)00118-3
更新日期：2002-12-01 00:00:00
abstract：:The purpose of this study is to investigate possible influences of different stressors (saline injections, light deprivation and constant light regimen) and geroprotectors (Epitalon and melatonin) on survivals of female HER-2/neu transgenic mice. We propose a semi-parametric model of heterogeneous mortality (frailty m...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.08.007
更新日期：2004-10-01 00:00:00
abstract：INTRODUCTION:Aging leads to poorer neuromuscular control that may impact mobility. However, the specific decades when these changes occur, and whether these time-based changes are sex-specific, are unclear. METHODS:Adults aged 20-82 years (N = 93, 51 females) walked six gait trials at their preferred speed over a 10-m...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2018.05.005
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The cortisol awakening response (CAR) is a useful endocrine marker for the hypothalamic-pituitary-adrenal axis activity. Recent studies suggest that the cortisol level influences the expression of the hPER1 clock gene which is involved in the generation of biological rhythms. This study aimed t...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2012.04.009
更新日期：2012-07-01 00:00:00
abstract：:Aging is associated with diminished regenerative capacity and increased risk of chronic diseases. There is now compelling evidence suggests that aging process is reversible. Besides metabolic modification and systematic factors, both senescence elimination and cellular reprogramming showed beneficial effects on tissue...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2020.111005
更新日期：2020-09-01 00:00:00
abstract：:We have recently reported that activated mouse spleen mononuclear cells (MNCs) efficiently lyse autologous erythrocytes in vitro (Saxena and Chandrasekhar, 2000). In the present study, we have investigated erythrocyte-depleting ability (EDA) of spleen MNCs from young and old mice. Time kinetics of survival of erythroc...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00091-7
更新日期：2000-05-01 00:00:00
abstract：:The binding of advanced glycation endproducts (AGEs) to their receptors is known to cause changes in cell function during normal ageing and is implicated in the pathogenesis of cardiovascular disease. In this study, expression of the AGE-receptor 3 (AGE-R3) and the receptor for AGEs (RAGE) was compared on the mRNA and...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2003.12.006
更新日期：2004-03-01 00:00:00
abstract：BACKGROUND:Several studies reported an association between concentrations of serum uric acid and cognitive function, but the evidence is contradictory. It is known that uric acid is associated with cardiovascular diseases, especially among women. Stratifying by sex and history of cardiovascular disease may clarify whet...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.04.017
更新日期：2016-08-01 00:00:00
abstract：:Senescence accelerated mice (SAM) are susceptible to developing vascular dysfunction and remodeling. Food intake and type of diet have also been identified as determining factors in vascular remodeling. However, the interplay between senescence and diet in vascular remodeling is largely unknown. We aimed to analyze st...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.03.004
更新日期：2014-07-01 00:00:00
abstract：:Fragility fractures due to osteoporosis and its most dreaded complication - hip fractures - are the cause of disability, high mortality and place a considerable burden on global health economics. Although much work has been done to accurately predict mortality and find risk factors for poor health outcome, little atte...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.06.002
更新日期：2017-10-01 00:00:00
abstract：:The effect of deleting both catalase genes and of increased oxygen as well as paraquat (a pro-oxidant) on the replicative life span of yeast mother cells has been investigated to test the so-called oxygen theory of aging. This is well established in higher organisms, but has not been extensively tested in the unicellu...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(99)00087-x
更新日期：2000-02-01 00:00:00
abstract：:Women who seek medical care around the time of menopause frequently report changes in one or more aspects of psychological functioning. The etiology of these symptoms is likely multifactorial and, undoubtedly, individual and sociocultural factors are important determinants. The known psychotropic properties of the sex...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/0531-5565(94)90021-3
更新日期：1994-05-01 00:00:00
abstract：:A colony of male Lakeview Golden (LVG) Syrian hamsters has been maintained for the last nine years as a source of various tissues for cellular aging studies. Observations on this colony also yielded data on survival time and physical and pathological manifestations of aging in this strain. Based on 150 spontaneous dea...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(90)90032-w
更新日期：1990-01-01 00:00:00
abstract：:We determined the contribution of body fat distribution, peak VO2, fat mass, and dietary intake to variation in plasma lipids in elderly individuals. Volunteers were a healthy cohort of older Caucasian women (n = 75, mean age +/- SD, 72 +/- 5 years) and older men (n = 101, 72 +/- 5 years). We determined fat mass from ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(97)00052-1
更新日期：1997-11-01 00:00:00
abstract：:While influenza immunization significantly reduces the risk of pneumonia and associated deaths, vaccination of elderly only affords 30-50% protection against influenza disease. The purpose of this study was to: (1) evaluate the consistency of immune responses across multiple years in young and elderly; (2) determine t...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(01)00210-8
更新日期：2002-01-01 00:00:00
abstract：:We investigated the telomere lengths of individual cell types in lingual mucosa using an improved tissue quantitative fluorescence in situ hybridization (Q-FISH) method. Our tissue Q-FISH method compensates for partially cut nuclei in a tissue section by using the telomere:centromere ratio (TCR). We normalized our TCR...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2008.06.001
更新日期：2008-09-01 00:00:00
abstract：:The field of toxicology adopted the threshold dose response in the early decades of the 20th century. The model was rapidly incorporated into governmental regulatory assessment procedures and became a central feature of chemical evaluation and assessment. The toxicological community never validated the capacity of thi...
journal_title：Experimental gerontology
pub_type： 历史文章,杂志文章
doi：10.1016/j.exger.2012.02.004
更新日期：2013-01-01 00:00:00
abstract：:Telomeres serve as a mitotic clock and biological marker of senescence. Diabetes mellitus (DM) is associated with damage to target organs and premature aging. We assessed the effect of glycemic control on telomere dynamics in arterial cells of 58 patients undergoing coronary artery bypass and in mononuclear blood cell...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2007.07.005
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Geriatric patients are highly susceptible to infections. While reduced lymphocyte count has been associated with age, other studies found no change in WBC counts with age. Increased circulating white blood cell (WBC) count has been associated with cardiovascular (CV) diseases and frailty but there...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.11.016
更新日期：2015-01-01 00:00:00
abstract：:Advances in our understanding of tau-mediated neurodegeneration in Alzheimer's disease (AD) are moving this disease pathway to center stage for the development of biomarkers and disease modifying drug discovery efforts. Immunoassays were developed detecting total (t-tau) and tau phosphorylated at specific epitopes (p-...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2009.10.010
更新日期：2010-01-01 00:00:00
abstract：:Senescent cells accumulate with age and contribute to pathologies associated to old age. The senescent program can be induced by pro-cancer stimuli or is developmentally controlled. In cells forced to senesce by expression of oncogenes or short telomeres, aberrant activation of the ERK/MAP kinase signaling pathway lea...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2017.06.016
更新日期：2018-07-01 00:00:00
abstract：:Aging is the primary risk factor for functional decline; thus, understanding and preventing disability among older adults has emerged as an important public health challenge of the 21st century. The science of gerontology - or geroscience - has the practical purpose of "adding life to the years." The overall goal of g...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2020.111123
更新日期：2020-12-01 00:00:00
abstract：:Activation of the unfolded protein response (UPR) in the endoplasmic reticulum (ER) and mitochondrial apoptotic pathway serves as a central regulator for maintaining cell function and survival, and is associated with ageing and spermatogenesis. However, changes in UPR activation and mitochondrial apoptotic pathway in ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.110721
更新日期：2019-11-01 00:00:00
abstract：:Aging is associated with a progressive decline of muscle mass, strength, and quality, a condition described as sarcopenia of aging. Despite the significance of skeletal muscle atrophy, the mechanisms responsible for the deterioration of muscle performance are only partially understood. The purpose of this review is to...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2008.05.003
更新日期：2009-01-01 00:00:00
