Abstract：
BACKGROUND/OBJECTIVES:Geriatric patients are highly susceptible to infections. While reduced lymphocyte count has been associated with age, other studies found no change in WBC counts with age. Increased circulating white blood cell (WBC) count has been associated with cardiovascular (CV) diseases and frailty but there are discrepancies. Frailty, geriatric conditions, cardiovascular diseases and WBC count have also been associated with low grade inflammation. Association between geriatric conditions and WBC has been scarcely studied. The aim of the study is to assess the association between WBC and geriatric conditions, CV diseases, and seric IL-6 levels. DESIGN, SETTING, PARTICIPANTS, MEASUREMENTS:We recruited 100 subjects in the general population and hospitalized for chronic medical conditions (age, 23-96years). We collected information on clinical status (medical history, comorbidities, treatments and geriatric syndromes), biological parameters (hematological tests, cytomegalovirus serology) and cytokine production (basal IL-6). Using stepwise backward multivariate analyses, we defined which set of clinical and biological variables could be predictive of increased total and differential WBC counts. RESULTS:We found that low-grade inflammation is independently associated with total WBC, monocyte and neutrophil counts, but not geriatric conditions. CV diseases were the only significant associated factor for high monocyte count. CONCLUSION:In this study, we observed that differential and total WBC counts do not seem to be associated with geriatric conditions but with CV diseases, low-grade inflammation and telomere length.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Compté N,Bailly B,De Breucker S,Goriely S,Pepersack Tdoi
10.1016/j.exger.2014.11.016subject
Has Abstractpub_date
2015-01-01 00:00:00pages
105-12eissn
0531-5565issn
1873-6815pii
S0531-5565(14)00341-6journal_volume
61pub_type
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journal_title：Experimental gerontology
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pub_type： 杂志文章,评审
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doi：10.1016/s0531-5565(99)00026-1
更新日期：1999-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1993-07-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.12.002
更新日期：2018-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00157-1
更新日期：2000-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.exger.2016.07.013
更新日期：2016-10-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2016.09.007
更新日期：2016-12-01 00:00:00
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pub_type： 杂志文章,随机对照试验
doi：10.1016/j.exger.2018.06.007
更新日期：2018-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.05.014
更新日期：2014-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2014-04-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：2020-09-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2015-10-01 00:00:00
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更新日期：2004-04-01 00:00:00
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更新日期：2004-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2001-01-01 00:00:00
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