当前位置： SCI文献检索 > EXPERIMENTAL GERONTOLOGY期刊下所有文献 > Tart cherry concentrate does not enhance muscle protein synthesis response to exercise and protein in healthy older men.

Tart cherry concentrate does not enhance muscle protein synthesis response to exercise and protein in healthy older men.

Abstract：

BACKGROUND:Oxidative stress and inflammation may contribute to anabolic resistance in response to protein and exercise in older adults. We investigated whether consumption of montmorency cherry concentrate (MCC) increased anabolic sensitivity to protein ingestion and resistance exercise in healthy older men. METHODS:Sixteen healthy older men were randomized to receive MCC (60 mL·d-1) or placebo (PLA) for two weeks, after baseline measures in week 1. During week 3, participants consumed 10 g whey protein·d-1 and completed three bouts of unilateral leg resistance exercise (4 × 8-10 repetitions at 80% 1RM). Participants consumed a bolus (150 mL) and weekly (50 mL) doses of deuterated water. Body water 2H enrichment was measured in saliva and vastus lateralis biopsies were taken from the non-exercised leg after weeks 1, 2 and 3, and the exercised leg after week 3, to measure tracer incorporation at rest, in response to protein and protein + exercise. RESULTS:Myofibrillar protein synthesis increased in response to exercise + protein compared to rest (p < 0.05) in both groups, but there was no added effect of supplement (MCC: 1.79 ± 0.75 EX vs 1.15 ± 0.40 rest; PLA: 2.22 ± 0.54 vs 1.21 ± 0.18; all %·d-1). Muscle total NFĸB protein was decreased with exercise and protein in MCC (NFĸB: -20.7 ± 17.5%) but increased in PLA (NFĸB: 17.8 ± 31.3%, p = 0.073). CONCLUSION:Short-term MCC ingestion does not affect the anabolic response to protein and exercise in healthy, relatively active, older men, despite MCC ingestion attenuating expression of proteins involved in the muscle inflammatory response to exercise, which may influence the chronic training response.

journal_name

Exp Gerontol

journal_title

Experimental gerontology

authors

Jackman SR,Brook MS,Pulsford RM,Cockcroft EJ,Campbell MI,Rankin D,Atherton P,Smith K,Bowtell JL

doi

10.1016/j.exger.2018.06.007

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

202-208

eissn

0531-5565

issn

1873-6815

pii

S0531-5565(17)30840-9

journal_volume

110

pub_type

杂志文章,随机对照试验

在线工具

Tart cherry concentrate does not enhance muscle protein synthesis response to exercise and protein in healthy older men.