Abstract：
BACKGROUND:Resistance exercise training (RET) has proven effective at reducing the risk of chronic disease in older populations, and it appears to regulate redox homeostasis. AIMS:To determine the effects of RET on redox homeostasis in older people. STUDY DESIGN:A systematic review and meta-analysis of randomized clinical trials identified by searching MEDLINE, Web of Science, EMBASE, Sportdiscus, LILACS, CENTRAL and CINAHL. We included studies of subjects aged 65 years or older, with or without pathologies, and including RET metrics with quantified molecular oxidation and antioxidant capacity outcomes. RESULTS:Fifteen studies were included in this review. Agreement between reviewers reached a kappa value of 0.725. There were a total of 614 participants, with an average age of 68.1 years. Five (for molecular oxidation markers) and three (for antioxidant capacity markers) studies included data that quantified the effects of RET on homeostasis redox. The results of the meta-analysis showed that there were no differences in the molecular oxidation markers (SMD = -0.26; 95% CI = -0.57 to 0.05; P = 0.10; I2 = 0%) and antioxidant capacity markers (SMD = 0.53; 95% CI = -0.20 to 1.26; P = 0.16; I2 = 71.5%) in healthy older people after a RET of 8-24 weeks compared to non-intervention. CONCLUSIONS:Based on a small number of studies of low methodological quality, this systematic review with meta-analysis suggests that RET is not effective at reducing molecular oxidation markers in healthy older people. More research is needed on the effects of RET on redox homeostasis in older people. PROSPERO REGISTRATION NUMBER:CRD42019121529.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Cuyul-Vásquez I,Berríos-Contreras L,Soto-Fuentes S,Hunter-Echeverría K,Marzuca-Nassr GNdoi
10.1016/j.exger.2020.111012subject
Has Abstractpub_date
2020-09-01 00:00:00pages
111012eissn
0531-5565issn
1873-6815pii
S0531-5565(20)30360-0journal_volume
138pub_type
杂志文章,评审abstract：:Raw bioelectrical impedance analysis (BIA) data [resistance (R); reactance (Xc)] through bioelectrical impedance vector analysis (BIVA) and phase angle (PhA) have been used to evaluate cellular function and hydration status. The purpose of this investigation was to examine the effects of resistance training (RT) on cl...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.12.002
更新日期：2016-02-01 00:00:00
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journal_title：Experimental gerontology
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更新日期：2015-12-01 00:00:00
abstract：:We have isolated a senescence-specific clone (pSEN) from a cDNA library constructed from late passage WI-38 human diploid fibroblast that accounts for approximately 1% of the recombinants. Nucleotide sequence analysis of the partial cDNA clone has led to the identification of pSEN as elongation factor I alpha. Norther...
journal_title：Experimental gerontology
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doi：10.1016/0531-5565(89)90056-9
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abstract：:Aging is associated with a change in membrane composition that includes a decrease in membrane polyunsaturated fatty acids, including arachidonic acid, and an increase in membrane cholesterol. Alterations in membrane structure are likely to impact on transmitter release, which relies on the fusion of synaptic plasma a...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(97)00130-7
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abstract：:The loss of bone mineral with aging and subsequent development of osteoporosis is a common problem in elderly women, and as life expectancy increases, in elderly men as well. Space flight also causes bone loss and could be a limiting factor for long duration missions, such as, a Mars expedition or extended occupation ...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/0531-5565(91)90011-a
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
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journal_title：Experimental gerontology
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doi：10.1016/0531-5565(87)90031-3
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.05.015
更新日期：2017-10-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(91)90037-m
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.03.015
更新日期：2016-06-15 00:00:00
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.05.055
更新日期：2013-08-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.11.016
更新日期：2015-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.02.009
更新日期：2014-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：1989-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：2018-07-15 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.07.002
更新日期：2009-10-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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journal_title：Experimental gerontology
pub_type： 杂志文章
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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更新日期：1998-11-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：2007-08-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：2000-05-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：1990-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 临床试验,杂志文章
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更新日期：2019-05-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：1994-03-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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更新日期：2003-04-01 00:00:00
