Donor's age and replicative senescence favour the in-vitro mineralization potential of human fibroblasts.

abstract：:Permethrin is a synthetic pyrethroid extensively used as anti-woodworm agent and for indoor and outdoor pest control. The main route of human exposure is through fruit, vegetable and milk intake. Low dosage exposure to permethrin during neonatal brain development (from postnatal day 6 to postnatal day 21) leads to dop...

journal_title：Experimental gerontology

authors： Bordoni L,Nasuti C,Fedeli D,Galeazzi R,Laudadio E,Massaccesi L,López-Rodas G,Gabbianelli R

更新日期：2019-09-01 00:00:00

abstract：:Rodent animal models take at least 18months to develop aging phenotypes for researchers to investigate the mechanism of age-related metabolic complications. Senescence-accelerated mouse prone 8 (SAMP8) shortens the process of aging and may facilitate an alternative model for studying age-related insulin resistance. Th...

journal_title：Experimental gerontology

authors： Liu HW,Chan YC,Wei CC,Chen YA,Wang MF,Chang SJ

更新日期：2017-12-01 00:00:00

abstract：:The importance of maintaining physical fitness by engaging in exercise in a life-long perspective as well as the avoidance of obesity has been emphasised in recent years by epidemiological studies on human populations as well as studies on laboratory rodents. In laboratory studies, voluntary running in wheels and forc...

journal_title：Experimental gerontology

authors： Narath E,Skalicky M,Viidik A

更新日期：2001-11-01 00:00:00

abstract：:Recently, it has been suggested that oxytocin (OT) might play a role in the control of bone remodeling and in bone health of young and adult females. The purpose of this study was to evaluate the effect of osteogenic medium (OM) plus OT (OM + OT; 100 nmol/L) on osteoblastic differentiation of bone marrow mesenchymal s...

journal_title：Experimental gerontology

authors： Santos LF,Singulani MP,Stringhetta-Garcia CT,Oliveira SHP,Chaves-Neto AH,Dornelles RCM

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Hyaline articular cartilage, which protects the bones of diarthrodial joints from forces associated with load bearing, frictions, and impacts has very limited capacities for self-repair. Over the years, the trend of treatments has shifted to regenerations and researchers have been on the quest for a lasting ...

journal_title：Experimental gerontology

authors： Ude CC,Shamsul BS,Ng MH,Chen HC,Ohnmar H,Amaramalar SN,Rizal AR,Johan A,Norhamdan MY,Azizi M,Aminuddin BS,Ruszymah BHI

更新日期：2018-04-01 00:00:00

abstract：:While it may be possible to employ panels of molecular parameters which correlate with senescence in vivo or in vitro, in a manner analogous to the use of mutagenesis assays for economic carcinogen screening, such an endeavor would at present be impeded by the absence of a clear mechanistic rationale for focusing on p...

journal_title：Experimental gerontology

authors： Shmookler Reis RJ

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Homocysteine (Hcy) high levels are associated with fractures, bone resorption and an early onset of osteoporosis in elderly persons; a relationship between Hcy and bone formation has also been suggested but is still controversial. Frailty, an independent predictor of fractures and decreased bone mineral dens...

journal_title：Experimental gerontology

authors： Álvarez-Sánchez N,Álvarez-Ríos AI,Guerrero JM,García-García FJ,Rodríguez-Mañas L,Cruz-Chamorro I,Lardone PJ,Carrillo-Vico A

更新日期：2018-07-15 00:00:00

abstract：OBJECTIVE:To assess the effect of genetic and non-genetic factors on indicators derived from waist circumference (WC) and body mass index (BMI) as well as inter-indicator differences in risk assessment age-related diseases including diabetes mellitus, coronary heart disease and liver cancer. METHODS:Height, weight and...

journal_title：Experimental gerontology

authors： Xin G,Shong L,Hui L

更新日期：2014-12-01 00:00:00

abstract：:The effect of 3-(4-pyridyl)-1,2,4-thiotriazolyl 5-mercaptoacetic acid kalium salt (Rumosol) and 3-(4-pyridyl)-1,2,4-thiotriazolyl 5-mercaptoacetic acid morpholinium salt (drug 2) on the concentration of Schiff base in myocardium of adult (10-12 months) and old (22-25 months) Wistar rats during immobilized stress were ...

journal_title：Experimental gerontology

authors： Davydov VV,Shvets VN

更新日期：2002-04-01 00:00:00

abstract：:SIRT1 is a highly conserved NAD(+)-dependent protein deacetylase known to have protective effects against a variety of age-related diseases. However, there is a lack of information concerning SIRT1 expression in the cochlea and auditory cortex of C57BL/6 mice, a mouse model of age-related hearing loss. Using RT-PCR an...

journal_title：Experimental gerontology

authors： Xiong H,Dai M,Ou Y,Pang J,Yang H,Huang Q,Chen S,Zhang Z,Xu Y,Cai Y,Liang M,Zhang X,Lai L,Zheng Y

更新日期：2014-03-01 00:00:00

abstract：:Free-living organisms are exposed to a wide range of stressors, all of which can disrupt components of stress-related and detoxification physiology. The subsequent accumulation of somatic damage is widely believed to play a major role in the evolution of senescence. Organisms have evolved sophisticated physiological r...

journal_title：Experimental gerontology

authors： Watson H,Cohen AA,Isaksson C

更新日期：2015-11-01 00:00:00

abstract：:The Senescence-Accelerated Mouse (SAM) strains are unique and appropriate models for genetic studies on aging because the SAMP strains have an "accelerated senescence" phenotype for which the SAMR strains are controls, and each SAMP strain has a strain-specific age-associated disorder. Furthermore, because they have g...

journal_title：Experimental gerontology

authors： Higuchi K

更新日期：1997-01-01 00:00:00

abstract：:Aging is the major risk factor for numerous brain diseases. This is especially true for Alzheimer's disease (AD), a peculiar neurodegenerative disorder in that it results from the synergy of two simultaneous but distinct degenerating processes: A beta and tau pathologies. For AD, and for most neurodegenerative disorde...

journal_title：Experimental gerontology

authors： Delacourte A,Sergeant N,Buée L

更新日期：2003-11-01 00:00:00

abstract：:Sex hormones are known to help maintaining the cognitive ability in male and female rats. Hypogonadism results in the reduction of the dendritic spines of central neurons which is believed to undermine memory and cognition and cause fatigue and poor concentration. In our previous studies, we have reported age-related ...

journal_title：Experimental gerontology

authors： Chen JR,Tseng GF,Wang YJ,Wang TJ

更新日期：2014-09-01 00:00:00

abstract：:Age-related declines in human skeletal muscle performance may be caused, in part, by decreased responsivity of muscle fibers to calcium (Ca2+). This study examined the contractile properties of single vastus lateralis muscle fibers with various myosin heavy chain (MHC) isoforms (I, I/IIA, IIA and IIAX) across a range ...

journal_title：Experimental gerontology

authors： Straight CR,Ades PA,Toth MJ,Miller MS

更新日期：2018-02-01 00:00:00

abstract：:Despite general belief that the mechanical properties of bone material contribute to whole bone strength, it is still obscure what the age effects are on mechanical behavior of the bone material, particularly in the case of the femoral neck trabeculae. In this study, atomic force microscopy was used for imaging and me...

journal_title：Experimental gerontology

authors： Milovanovic P,Potocnik J,Djonic D,Nikolic S,Zivkovic V,Djuric M,Rakocevic Z

更新日期：2012-02-01 00:00:00

abstract：:DNA binding of the ku protein was investigated in peripheral blood mononuclear cells (PBMC) from 24 subjects of different ages (20-89 years old) displaying age-related changes in DNA repair, mitotic responsiveness, and cytokine production. Ku is an heterodimeric protein composed of two subunits of 70 and 80 kDa, which...

journal_title：Experimental gerontology

authors： Frasca D,Barattini P,Tirindelli D,Guidi L,Bartoloni C,Errani A,Costanzo M,Tricerri A,Pierelli L,Doria G

更新日期：1999-08-01 00:00:00

abstract：:Plasma and pituitary concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin (Prl) were determined by radioimmunoassay in young (2-4 months-old) and aged CD-1 (14-18 months-old) and C57BL/6 (16-22 months-old) mice one month after ovariectomy. In young, ovariectomized mice, plasma ...

journal_title：Experimental gerontology

authors： Parkening TA,Collins TJ,Smith ER

更新日期：1982-01-01 00:00:00

abstract：:Declines in mobility with advancing age are often associated with a reduction in the use of lower leg muscles. We examined the influence of two interventions that involved neuromuscular electrical stimulation (NMES) applied to the triceps surae muscles on the mobility and muscle function of older adults. Thirty health...

journal_title：Experimental gerontology

authors： Mani D,Almuklass AM,Amiridis IG,Enoka RM

更新日期：2018-07-15 00:00:00

abstract：:Mitochondrial superoxide production is an important source of reactive oxygen species in cells, and may cause or contribute to ageing and the diseases of ageing. Seven major sites of superoxide production in mammalian mitochondria are known and widely accepted. In descending order of maximum capacity they are the ubiq...

journal_title：Experimental gerontology

authors： Brand MD

更新日期：2010-08-01 00:00:00

abstract：:The APOE epsilon4 allele has been associated with a number of neurodegenerative disorders e.g. Alzheimer's disease. Inconsistent results have been obtained for cognitive decline in 'normal' aging. We investigated whether specific aspects of cognitive decline were associated with APOE epsilon4 among 620 'healthy' elder...

journal_title：Experimental gerontology

authors： De Blasi S,Montesanto A,Martino C,Dato S,De Rango F,Bruni AC,Mari V,Feraco E,Passarino G

更新日期：2009-03-01 00:00:00

abstract：:Skeletal muscle atrophy reduces quality of life and increases morbidity and mortality in patients with chronic conditions. Oxidative stress is a key factor contributing to skeletal muscle atrophy by altering both protein synthesis and protein degradation pathways. Beta-lapachone (Beta-L) is known to act as a pro-oxida...

journal_title：Experimental gerontology

authors： Park S,Shin MG,Kim JR,Park SY

更新日期：2019-10-15 00:00:00

abstract：:This study was aimed at determining the effect of exercise and vitamin E on age-associated changes in the superoxide dismutase (SOD), lipid (LPO) and protein oxidations (PO) in the cerebral cortex (CC), cerebellum (CB) and hippocampus (HC) of rat brain. For this, male Wistar albino rats of 4- (adult), 12- (middle-age)...

journal_title：Experimental gerontology

authors： Jolitha AB,Subramanyam MV,Asha Devi S

更新日期：2006-08-01 00:00:00

abstract：:Type 2 diabetes is associated with progressive beta-cell failure manifest as a decline in insulin secretion and increasing hyperglycemia. A growing body of evidence suggests that beta-cell failure in type 2 diabetes correlates with the formation of pancreatic islet amyloid deposits, indicating that islet amyloid may h...

journal_title：Experimental gerontology

authors： Marzban L,Park K,Verchere CB

更新日期：2003-04-01 00:00:00

abstract：:Age- and sex-associated differences in lipid peroxidation (LPO), and total sialic acid content (TSA) in response to abuse of drugs have been reported both in humans and experimental animals. However, no data on the influence of gender and age on these parameters have been reported for methionine-enkephalin (MENK). In ...

journal_title：Experimental gerontology

authors： Sverko V,Sobocanec S,Balog T,Marotti T

更新日期：2002-12-01 00:00:00

abstract：:The geriatric populations of many countries are growing rapidly and they present major problems to healthcare infrastructures from both medical and economic perspectives. The elderly are predisposed to a variety of diseases, which contribute to a marked increase in morbidity in this subpopulation. The incidence of liv...

journal_title：Experimental gerontology

authors： Schmucker DL

更新日期：2005-08-01 00:00:00

abstract：:Reactive oxygen species (ROS) play important roles in cellular senescence and organismic aging. Furthermore, they have been implicated in some of the adverse effects of chronic stress due to elevated peripheral levels of catecholamines. Here, we applied three different techniques to individually compare the systemic a...

journal_title：Experimental gerontology

authors： Schraml E,Quan P,Stelzer I,Fuchs R,Skalicky M,Viidik A,Schauenstein K

更新日期：2007-11-01 00:00:00

abstract：:The loss of bone mineral with aging and subsequent development of osteoporosis is a common problem in elderly women, and as life expectancy increases, in elderly men as well. Space flight also causes bone loss and could be a limiting factor for long duration missions, such as, a Mars expedition or extended occupation ...

journal_title：Experimental gerontology

authors： LeBlanc A,Schneider V

更新日期：1991-01-01 00:00:00

abstract：:Indigenous DNA adducts (I-compounds) are considered to be a biomarker of aging tissues. Thus far, few studies have been conducted to investigate the accumulation patterns of I-compounds in the brain during aging. Particularly, identities of age-dependent I-compounds have largely remained unknown. In the current study,...

journal_title：Experimental gerontology

authors： Cai Q,Tian L,Wei H

更新日期：1996-05-01 00:00:00

abstract：:Primary human dermal fibroblasts isolated from the medial aspect of the proximal forearm of young and old donors were compared for the expression of interstitial collagenase, 72 kDa type IV collagenase, the tissue inhibitor of metalloproteinase type 1, and pro-alpha 2 (I) collagen mRNA at basal levels and after stimul...

journal_title：Experimental gerontology

authors： Burke EM,Horton WE,Pearson JD,Crow MT,Martin GR

更新日期：1994-01-01 00:00:00