Aberrant signaling and senescence associated protein degradation.

abstract：:Progressive neuronal deterioration accompanied by sensory functions decline is typically observed during aging. On the other hand, structural or functional alterations of specific sensory neurons extend lifespan in the nematode Caenorhabditis elegans. Hormesis is a phenomenon by which the body benefits from moderate s...

journal_title：Experimental gerontology

authors： Maglioni S,Schiavi A,Runci A,Shaik A,Ventura N

更新日期：2014-08-01 00:00:00

abstract：:The objective of this study was to determine whether and to what extent age-related changes occur in atrioventricular (AV) heart valve innervation. The AV valves from three young adult (3 months) and three older (> 24 months) female guinea pigs were studied. An acetylcholinesterase (AChE) localization method was used ...

journal_title：Experimental gerontology

authors： Folan-Curran J,Wang YF,Jew JY,Williams TH

更新日期：1994-09-01 00:00:00

abstract：:Like the weather, many people talk about aging, but no one seems able to do anything about it. This implacability derives, at least in part, from our inability to provide a conceptual base from which analytic insight might derive. The emerging field of nonlinear thermodynamics presents a new view of the universe. It r...

journal_title：Experimental gerontology

authors： Bortz WM 2nd

更新日期：1986-01-01 00:00:00

abstract：:The effect of aging was tested on experimental ventricular arrhythmias in isolated heart preparations from normal Wistar rats (NWR), Wistar Kyoto rats (WKY), and spontaneously hypertensive rats (SHR). Delayed afterdepolarizations and triggered activity induced by high-calcium perfusion (16 mM) in isolated papillary mu...

journal_title：Experimental gerontology

authors： Carbonin PU,Di Gennaro M,Pahor M,Bernabei R,Sgadari A,Gambassi G Jr

更新日期：1990-01-01 00:00:00

abstract：:The effect of DL-alpha-lipoic acid on lipid peroxidation and antioxidant enzymes were evaluated in various brain regions of young and aged rats. Lipoate contents of discrete brain regions were also measured. In aged rats, the activities of superoxide dismutase, glutathione peroxidase, glutathione reductase and glucose...

journal_title：Experimental gerontology

authors： Arivazhagan P,Shila S,Kumaran S,Panneerselvam C

更新日期：2002-06-01 00:00:00

abstract：:During aging declining maximum force capacity with more or less unchanged fatigability is observed with the underlying mechanisms still not fully understood. Therefore, we compared morphology and function of skeletal muscles between different age groups. Changes in high-energy phosphate turnover (PCr, Pi and pH) and m...

journal_title：Experimental gerontology

authors： Hiepe P,Gussew A,Rzanny R,Kurz E,Anders C,Walther M,Scholle HC,Reichenbach JR

更新日期：2015-05-01 00:00:00

abstract：:The interrelationship between muscle strength, motor unit (MU) number, and age is poorly understood, and in this study we sought to determine whether age-related differences in muscle strength are moderated by estimates of functioning MU number and size. Eighteen older adults (OA; 67 ± 1.20 years) and 24 young adults ...

journal_title：Experimental gerontology

authors： Kaya RD,Nakazawa M,Hoffman RL,Clark BC

更新日期：2013-09-01 00:00:00

abstract：:Prior to three months of age there is little melatonin (MLT) secretion in humans. MLT production then commences, becomes circadian, and reaches its highest nocturnal blood levels between the ages of one to three years. During the remainder of childhood, nocturnal peak levels drop progressively by 80%. In adults, these...

journal_title：Experimental gerontology

authors： Waldhauser F,Kovács J,Reiter E

更新日期：1998-11-01 00:00:00

abstract：:Aging in Brown Norway rats is accompanied by the reduced production of testosterone by the Leydig cells, the testicular cells responsible for synthesizing and secreting this essential steroid. As yet, the mechanism by which Leydig cell steroidogenesis is reduced is unknown. Herein we assess the production of mitochond...

journal_title：Experimental gerontology

authors： Chen H,Cangello D,Benson S,Folmer J,Zhu H,Trush MA,Zirkin BR

更新日期：2001-08-01 00:00:00

abstract：:Mitochondria play a critical role in the life of the cell as they control their metabolic rate, energy production and cell death. Mitochondria have long been appreciated as causative to aging. The age-associated respiratory chain deficiency is typically unevenly distributed and affects only a subset of cells in variou...

journal_title：Experimental gerontology

authors： Kukat A,Trifunovic A

更新日期：2009-01-01 00:00:00

abstract：:Thiazolidine carboxylic acid (TCA) is a natural liver metabolite whose Mg-salt increased lifespan of flies and mice (Miquel and Economos, 1979, Exp. Geront. 14: 279). We studied the physiological and cellular fine structural effects of various concentrations of TCA in the food of male Drosophila. Flies on 0.3% TCA at ...

journal_title：Experimental gerontology

authors： Economos AC,Ballard RC,Miquel J,Binnard R,Philpott DE

更新日期：1982-01-01 00:00:00

abstract：:Age-related behavioral declines are common manifestations of aging in animals. Negative geotaxis, an innate escape response during which flies ascend the wall of a cylinder after being tapped to its bottom, is one of the behaviors that senesces in Drosophila. Many laboratories, including ours, have used a variety of n...

journal_title：Experimental gerontology

authors： Gargano JW,Martin I,Bhandari P,Grotewiel MS

更新日期：2005-05-01 00:00:00

abstract：:The antioxidant 2-mercaptoethylamine (MEA) was added to the culture medium of WI-38 cells throughout their lifespan. MEA concentrations of 0.5 microM, 5 microM and 50 microM were used. The presence of 5 microM or 50 microM MEA decreased the fraction of rapidly dividing cells and slightly reduced cell density at conflu...

journal_title：Experimental gerontology

authors： Golczewski JA

更新日期：1984-01-01 00:00:00

abstract：:Protein nitration occurs as a result of oxidative stress induced by reactive oxygen (ROS) and reactive nitrogen species (RNS). Therefore, protein nitration serves as a hallmark for protein oxidation in vivo. We have previously reported on age dependent protein nitration in cardiac tissue of Fisher 344 BN-F1 rats analy...

journal_title：Experimental gerontology

authors： Hong SJ,Gokulrangan G,Schöneich C

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Several studies reported an association between concentrations of serum uric acid and cognitive function, but the evidence is contradictory. It is known that uric acid is associated with cardiovascular diseases, especially among women. Stratifying by sex and history of cardiovascular disease may clarify whet...

journal_title：Experimental gerontology

authors： Perna L,Mons U,Schöttker B,Brenner H

更新日期：2016-08-01 00:00:00

abstract：:Age-related changes in cancer mortality risk are important for understanding the processes of disease and aging interaction. The extent to which these age changes differ by sex further contributes to this understanding but has not been well studied to date. We conducted a systematic examination of dynamics and heterog...

journal_title：Experimental gerontology

authors： Yang Y,Li T,Nielsen ME

更新日期：2012-09-01 00:00:00

abstract：:Coronary heart disease is less prevalent in pre-menopausal women than in men, but increases at the onset of menopause. This delay is due to estrogen protective effects. The rise of cholesterolemia is one of the main risk factors for coronary disease. Since 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) is the ...

journal_title：Experimental gerontology

authors： Trapani L,Violo F,Pallottini V

更新日期：2010-02-01 00:00:00

abstract：:Accumulation of altered proteins is the most common molecular symptom of ageing. Altered proteins are also associated with many age-related pathologies. Altered proteins are continuously produced but are normally selectively degraded by cellular proteases; their accumulation during ageing may be explained by either or...

journal_title：Experimental gerontology

authors： Hipkiss AR

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVES:To date studies evaluating the relation between circulating aldosterone levels and mortality in elderly female individuals are lacking. We therefore aimed to assess the relationship between circulating aldosterone levels and mortality in a population-based cohort study of female nursing home residents. METH...

journal_title：Experimental gerontology

authors： Tomaschitz A,Pilz S,Pieske B,Ritz E,März W,Meinitzer A,Dobnig H,Amrein K,Kienreich K,Verheyen N,Kraigher-Krainer E,Drechsler C,Colantonio C,Wagner D,Fahrleitner-Pammer A

更新日期：2013-03-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by amyloid-β plaques, tau pathology and vascular impairment including pericyte damage. Pericytes are perivascular cells of the blood-brain barrier and can differentiate into different cell types in vitro including microglia. The aim of the present study is to explore if primar...

journal_title：Experimental gerontology

authors： Hutter-Schmid B,Humpel C

更新日期：2018-10-02 00:00:00

abstract：:Reflective of age-associated decline in immune function among elderly individuals is a decrease in in vitro T cell proliferative ability. Impaired T cell proliferation in the elderly may result from disruption of the well-balanced network of regulatory cytokines produced during an immune response. The purpose of this ...

journal_title：Experimental gerontology

authors： Castle SC,Uyemura K,Crawford W,Wong W,Klaustermeyer WB,Makinodan T

更新日期：1999-04-01 00:00:00

abstract：:Aging is associated with a reduction in the maximum density of n-methyl-d-aspartate (NMDA)-sensitive glutamate binding sites in the hippocampus of Fischer 344 rats. This study was designed to investigate the effect of acetyl-l-carnitine (ALCAR) on NMDA receptors in the old rat (24 months) after chronic or single-dose ...

journal_title：Experimental gerontology

authors： Castorina M,Ambrosini AM,Giuliani A,Pacifici L,Ramacci MT,Angelucci L

更新日期：1993-11-01 00:00:00

abstract：:Alterations in heparan sulfate, the principal glycosaminoglycan species in glomerular basement membrane, have been proposed as contributory to permeability changes in nephropathic disorders. In the present study, the extent of sulfation of glycosaminoglycans isolated from pronase digests of human glomerular basement m...

journal_title：Experimental gerontology

authors： Cohen MP,Ku L

更新日期：1983-01-01 00:00:00

abstract：:The hypotheses were: HISS-dependent insulin resistance (HDIR) accounts for insulin resistance that occurs with aging; HDIR is the initiating metabolic defect that leads progressively to type 2 diabetes and the metabolic syndrome; a synergistic antioxidant cocktail in chow confers protection against HDIR, subsequent sy...

journal_title：Experimental gerontology

authors： Lautt WW,Ming Z,Macedo MP,Legare DJ

更新日期：2008-08-01 00:00:00

abstract：:A growing body of evidence indicates that dysregulation of cerebral biometals (Fe, Cu, Zn) and their interactions with APP and Abeta amyloid may contribute to the Alzheimer's amyloid pathology, and thus metal chelation could be a rational therapeutic approach for interdicting AD pathogenesis. However, poor target spec...

journal_title：Experimental gerontology

authors： Dedeoglu A,Cormier K,Payton S,Tseitlin KA,Kremsky JN,Lai L,Li X,Moir RD,Tanzi RE,Bush AI,Kowall NW,Rogers JT,Huang X

更新日期：2004-11-01 00:00:00

abstract：:Age-related declines in human skeletal muscle performance may be caused, in part, by decreased responsivity of muscle fibers to calcium (Ca2+). This study examined the contractile properties of single vastus lateralis muscle fibers with various myosin heavy chain (MHC) isoforms (I, I/IIA, IIA and IIAX) across a range ...

journal_title：Experimental gerontology

authors： Straight CR,Ades PA,Toth MJ,Miller MS

更新日期：2018-02-01 00:00:00

abstract：:Age-related hearing loss (AHL) is a progressive neurodegenerative disease that is largely silent in its initial stages. There is no sensitive blood biomarker for diagnosis or early detection of AHL. MicroRNAs (miRNAs or miRs) are abundant and highly stable in blood, and have been recently described as powerful circula...

journal_title：Experimental gerontology

authors： Pang J,Xiong H,Yang H,Ou Y,Xu Y,Huang Q,Lai L,Chen S,Zhang Z,Cai Y,Zheng Y

更新日期：2016-04-01 00:00:00

abstract：:Cardiovascular disease (CVD) is an important public health problem affecting especially the elderly. Over the past 20years, an increasing number of studies have examined its underlying pathophysiological mechanisms and new therapies are continually being discovered. However, despite considerable progress in CVD manage...

journal_title：Experimental gerontology

authors： Recchioni R,Marcheselli F,Antonicelli R,Mensà E,Lazzarini R,Procopio AD,Olivieri F

更新日期：2017-12-15 00:00:00

abstract：:Rodent animal models take at least 18months to develop aging phenotypes for researchers to investigate the mechanism of age-related metabolic complications. Senescence-accelerated mouse prone 8 (SAMP8) shortens the process of aging and may facilitate an alternative model for studying age-related insulin resistance. Th...

journal_title：Experimental gerontology

authors： Liu HW,Chan YC,Wei CC,Chen YA,Wang MF,Chang SJ

更新日期：2017-12-01 00:00:00

abstract：:A longitudinal study was performed to confirm the inverse relationship between in vivo age and in vitro proliferative capacity previously observed in a cross-sectional study, and to investigate the relationship between the growth of dermal fibroblasts in vitro and a physiological function (i.e., wound repair) that is ...

journal_title：Experimental gerontology

authors： Bruce SA,Deamond SF

更新日期：1991-01-01 00:00:00