Abstract:
:Like the weather, many people talk about aging, but no one seems able to do anything about it. This implacability derives, at least in part, from our inability to provide a conceptual base from which analytic insight might derive. The emerging field of nonlinear thermodynamics presents a new view of the universe. It relates matter and energy in the framework of time. Entropy, "time's arrow," gives direction. Energy, rendered coherent through the metabolism of biology, acts to retard dissipation as entropy. For physicians, particularly those interested in geriatrics, this provides the challenge to understand how these forces are inscribed onto the human condition. The homeostatic controls which order our existence are energy dependent. As energies diminish, homeostasis as order deteriorates, aging proceeds and life is threatened. It seems to follow that if we are to diminish the entropic declines of aging our clinical strategies should emphasize actions which might retard the disruption of ordering processes. Homeostasis is at risk to the ravages of disease. This has been the standard business of medicine. But homeostasis is manifestly determined by the ordering effects of an energy flow. Either too little energy flow as disuse, or too much, as stress, lends further major burden to homeostatic controls. Every body system, at every level of organization, is beholden to this mandate. As our wisdom stretches to encompass the notion that aging and illness have other dimensions than just disease our view of ourselves will become more whole and in enlarging consonance with universal law.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Bortz WM 2nddoi
10.1016/0531-5565(86)90039-2subject
Has Abstractpub_date
1986-01-01 00:00:00pages
321-8issue
4-5eissn
0531-5565issn
1873-6815pii
0531-5565(86)90039-2journal_volume
21pub_type
杂志文章abstract::Spectrins are a part of cytoskeletal platform that lines the intracellular side of plasma membrane, which can be proteolyzed by calcium-sensitive enzymes including calpains and caspases. Caspase-3 mediated αII-spectrin proteolysis results in the release of a 120kDa spectrin breakdown product (SBDP120), known to occur ...
journal_title:Experimental gerontology
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.07.003
更新日期:2013-09-01 00:00:00
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journal_title:Experimental gerontology
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doi:10.1016/0531-5565(90)90072-a
更新日期:1990-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.12.002
更新日期:2018-02-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2007.04.010
更新日期:2007-08-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(98)00058-8
更新日期:1999-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(00)00256-4
更新日期:2001-03-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(90)90061-6
更新日期:1990-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.03.026
更新日期:2014-08-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2019.110781
更新日期:2020-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2015.02.006
更新日期:2015-04-01 00:00:00
abstract::Threat-related changes in postural control and their associations with changes in emotional and cognitive states are influenced by postural threat experience, however, limited work has explored individuals' capacity to adapt threat-related responses over longer periods of threat exposure. This study examined the effec...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2019.04.015
更新日期:2019-07-15 00:00:00
abstract::Young rhesus monkey females (Macaca mulatta) demonstrate the well-defined circadian rhythm in activity of erythrocyte SOD with maximum at 10.00 h and minimum at 22.00 h. However, neither GSH-Px nor GR demonstrated any significant circadian changes, contrastingly to SOD. The diurnal changes in the SOD activity tightly ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2006.04.006
更新日期:2006-08-01 00:00:00
abstract::Cytogenetic analysis of the X chromosome in phytohaemagglutinin stimulated peripheral blood lymphocytes was evaluated in 12 sporadic Alzheimer disease (AD) patients and in 11 healthy subjects. For chromosome analysis two methods were used: (1) standard analysis of G-banded metaphase chromosomes and; (2) fluorescent in...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2004.01.012
更新日期:2004-05-01 00:00:00
abstract::This study investigated the effects of two training programmes of 6 weeks combining strength and balance exercises in different proportions. One training programme [n=10; 71.4 (6.3) years] consisted mainly of strength exercises (ST) and the other programme [n=8; 71.4 (6.4) years] included a majority of balance exercis...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.11.013
更新日期:2015-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(94)90037-x
更新日期:1994-09-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2009.10.010
更新日期:2010-01-01 00:00:00
abstract::The APOE epsilon4 allele has been associated with a number of neurodegenerative disorders e.g. Alzheimer's disease. Inconsistent results have been obtained for cognitive decline in 'normal' aging. We investigated whether specific aspects of cognitive decline were associated with APOE epsilon4 among 620 'healthy' elder...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2008.11.005
更新日期:2009-03-01 00:00:00
abstract::Ageing is highly complex, involving multiple mechanisms at different levels. Nevertheless, recent evidence suggests that several of the most important mechanisms are linked via endogenous stress-induced DNA damage caused by reactive oxygen species (ROS). Understanding how such damage contributes to age-related changes...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(01)00111-5
更新日期:2001-07-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2005.10.010
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abstract:BACKGROUND:Sarcopenic obesity is a combination of both sarcopenia and obesity, which potentiate each other and maximize the negative influences of each, such as physical disability, morbidity, or even mortality. OBJECTIVES:To describe the criteria used to identify people with sarcopenic obesity and the components of t...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2020.110937
更新日期:2020-07-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2012.08.008
更新日期:2013-01-01 00:00:00
abstract::The purpose of this study was to examine the relative contributions of changes in muscle quality and body composition to changes in lower-extremity physical function (LEPF) following a 6-month exercise and weight loss intervention in overweight and obese older women. Thirty-eight overweight and obese (BMI = 30.0 ± 4.4...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2018.04.011
更新日期:2018-07-15 00:00:00
abstract::Dietary restriction extends lifespan in a variety of organisms, but the key nutritional components driving this process and how they interact remain uncertain. In Drosophila, while a substantial body of research suggests that protein is the major dietary component affecting longevity, recent studies claim that carbohy...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.02.003
更新日期:2013-10-01 00:00:00
abstract::In this study, spontaneous multiple unit activity (MUA, action potentials derived simultaneously from a number of neurons in a given brain region) was recorded through electrodes chronically implanted in the parietal cerebral cortex of the rats of 1, 3, 6, 9, 12, and 26 months of age (cross-sectional study). Electroph...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(88)90003-4
更新日期:1988-01-01 00:00:00
abstract::Aging-related changes to biological structures such as cardiovascular and musculoskeletal systems contribute to the development of comorbid conditions including cardiovascular disease and frailty, and ultimately lead to premature death. Although, frail older adults often demonstrate both cardiovascular and musculoskel...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2020.111220
更新日期:2021-03-01 00:00:00
abstract::This article addresses the description of several endocrine-related functions of the brain. It has emerged that steroids and growth factors may influence brain functions, and that brain cells may metabolize sex steroids. The crosstalk between different types of brain cells (neurons, astrocytes, the LHRH (luteinizing h...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(96)00172-6
更新日期:1997-07-01 00:00:00
abstract::For more than 60 years the only dietary manipulation known to retard aging was caloric restriction, in which a variety of species respond to a reduction in energy intake by demonstrating extended median and maximum life span. More recently, two alternative dietary manipulations have been reported to also extend surviv...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(02)00149-3
更新日期:2003-01-01 00:00:00
abstract::Aging is associated with a progressive decline of muscle mass, strength, and quality, a condition described as sarcopenia of aging. Despite the significance of skeletal muscle atrophy, the mechanisms responsible for the deterioration of muscle performance are only partially understood. The purpose of this review is to...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2008.05.003
更新日期:2009-01-01 00:00:00
abstract::Aging is associated with impaired mitochondrial function, whereas exercise training enhances mitochondrial content and function in part through activation of PGC-1α. Mitochondria form dynamic networks regulated by fission and fusion with profound effects on mitochondrial functions, yet the effects of aging and exercis...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.05.020
更新日期:2017-10-01 00:00:00