Abstract：
:Young rhesus monkey females (Macaca mulatta) demonstrate the well-defined circadian rhythm in activity of erythrocyte SOD with maximum at 10.00 h and minimum at 22.00 h. However, neither GSH-Px nor GR demonstrated any significant circadian changes, contrastingly to SOD. The diurnal changes in the SOD activity tightly correlate with the diurnal changes in the levels of cortisol and DHEAS in the animals' blood plasma. With aging, these circadian rhythms of SOD, cortisol and DHEAS are smoothed out although the correlation between the diurnal changes in cortisol and SOD still maintains even for old animals. These results suggest that corticosteroids play an essential role in regulation of the SOD activity and that the reliability of the hormonal regulation decreases with aging.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Goncharova ND,Shmaliy AV,Bogatyrenko TN,Koltover VKdoi
10.1016/j.exger.2006.04.006subject
Has Abstractpub_date
2006-08-01 00:00:00pages
778-83issue
8eissn
0531-5565issn
1873-6815pii
S0531-5565(06)00108-2journal_volume
41pub_type
杂志文章abstract：:Telomere length is considered as a biological marker for aging. It is expected that telomeres shorten with age and with conditions associated with oxidative stress and inflammation. Both are present in patients with chronic kidney disease (CKD) who have a very high cardiovascular risk. We investigated whether CKD dura...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.09.019
更新日期：2015-12-01 00:00:00
abstract：:Fragility fractures due to osteoporosis and its most dreaded complication - hip fractures - are the cause of disability, high mortality and place a considerable burden on global health economics. Although much work has been done to accurately predict mortality and find risk factors for poor health outcome, little atte...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.06.002
更新日期：2017-10-01 00:00:00
abstract：:Aging is an independent risk factor for the development of atherosclerosis, a vascular abnormality that plays a significant role in the development of many cardiovascular disorders. Animal experiments have demonstrated that aging predisposes the vasculature to advanced atherosclerotic disease and vessel injury and tha...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(99)00036-4
更新日期：1999-07-01 00:00:00
abstract：:Motor performance of rats of different ages was determined in a cross sectional study. The design includes a test battery of seven motor tasks of graduated complexity. The results show a hierarchical order of impairments of motor functions in aging rats; that is, the more complex the task requirement, the earlier and ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(83)90018-9
更新日期：1983-01-01 00:00:00
abstract：:The long life spans and slow aging rates of birds relative to mammals are paradoxical in view of birds' high metabolic rates, body temperatures and blood glucose levels, all of which are predicted to be liabilities by current biochemical theories of aging. Available avian life-table data show that most birds undergo r...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(00)00247-3
更新日期：2001-04-01 00:00:00
abstract：:Accumulation of altered proteins is the most common molecular symptom of ageing. Altered proteins are also associated with many age-related pathologies. Altered proteins are continuously produced but are normally selectively degraded by cellular proteases; their accumulation during ageing may be explained by either or...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2006.03.004
更新日期：2006-05-01 00:00:00
abstract：:Long-term caloric restriction (CR) has been shown to extend maximum life span in laboratory rodents. We investigated the activities of gluconeogenic and transaminase enzymes in the livers of old and young mice fed either control or calorie-restricted diets. Livers were sampled 48 h after the last scheduled feeding tim...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(02)00202-4
更新日期：2003-03-01 00:00:00
abstract：:Cellular aging plays a role in longevity and senescence, and has been implicated in medical and psychiatric conditions, including heart disease, cancer, major depression and posttraumatic stress disorder. Telomere shortening and mitochondrial dysfunction are thought to be central to the cellular aging process. The pre...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.04.002
更新日期：2015-06-01 00:00:00
abstract：:We have isolated a senescence-specific clone (pSEN) from a cDNA library constructed from late passage WI-38 human diploid fibroblast that accounts for approximately 1% of the recombinants. Nucleotide sequence analysis of the partial cDNA clone has led to the identification of pSEN as elongation factor I alpha. Norther...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(89)90056-9
更新日期：1989-01-01 00:00:00
abstract：:The interrelationship between muscle strength, motor unit (MU) number, and age is poorly understood, and in this study we sought to determine whether age-related differences in muscle strength are moderated by estimates of functioning MU number and size. Eighteen older adults (OA; 67 ± 1.20 years) and 24 young adults ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.06.008
更新日期：2013-09-01 00:00:00
abstract：:The purpose of this study was to examine the combined cardiorespiratory and cerebrovascular responses to head-up tilt (HUT) in young and older trained and untrained humans following moderate-duration exercise. Middle cerebral artery blood flow velocity (MCAv; transcranial Doppler ultrasound), blood pressure (BP; Finom...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2010.06.004
更新日期：2011-01-01 00:00:00
abstract：:Mouse models have been widely used in the research of human diseases. Aging, just as cancer, is influenced by the interaction of various genetic and environmental factors. Currently, aging could be induced by many mechanism, including telomere dysfunction, oxidase stress, DNA damage and epigenetic changes. Many of the...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2019.03.002
更新日期：2019-06-01 00:00:00
abstract：INTRODUCTION:Chronically elevated circulating inflammatory markers are common in older persons but mechanisms are unclear. Many blood transcripts (>800 genes) are associated with interleukin-6 protein levels (IL6) independent of age. We aimed to identify gene transcripts statistically mediating, as drivers or responder...
journal_title：Experimental gerontology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.exger.2015.05.012
更新日期：2015-10-01 00:00:00
abstract：:There have been some observations that low body weight and a low level of some hormones (e.g. IGF-1) during the first half of life are predictors of longer life in mice. However, contradictions in the available data on the biomarkers of aging and predictors of longevity have shown that the research in these fields has...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2003.12.007
更新日期：2004-03-01 00:00:00
abstract：:It is well established that the proliferative potential of the liver declines with aging. Epidermal growth factor (EGF)-stimulated DNA synthesis is reduced in hepatocytes from aged rats relative to young rats, and this reduction correlates with diminished activation of the extracellular signal-regulated kinase (ERK) p...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(02)00239-5
更新日期：2003-04-01 00:00:00
abstract：:Age-related bone loss is thought to be due to impaired osteoblast functions. Insulin-like growth factors (IGFs) have been shown to be important stimulators of bone formation and osteoblast activities in vitro and in vivo. We tested the hypothesis that in vitro osteoblast senescence is associated with changes in compon...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00125-x
更新日期：2000-10-01 00:00:00
abstract：:Dietary restriction (DR) extends lifespan in a wide range of organisms. DR also reduces daily and lifetime fecundity. The latter may be an evolutionary adaptation to survive periods of food shortage. Reproductive rate is often negatively correlated with lifespan, and a reduced cost of reproduction could be the mechani...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.03.018
更新日期：2004-07-01 00:00:00
abstract：OBJECTIVES:To date studies evaluating the relation between circulating aldosterone levels and mortality in elderly female individuals are lacking. We therefore aimed to assess the relationship between circulating aldosterone levels and mortality in a population-based cohort study of female nursing home residents. METH...
journal_title：Experimental gerontology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.exger.2013.01.004
更新日期：2013-03-01 00:00:00
abstract：:Young and old C57BL/6 male mice were given a diet containing a high dose of vitamin E (VE treatment) and its effect on the immune system was examined before and after the exposure to restraint stress. The VE treatment per se gave rise to a slight increase of splenic T cells in percentage and a significant enhancement ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(99)00055-8
更新日期：1999-11-01 00:00:00
abstract：:We tested the hypothesis that hesperidin would reverse age-related aortic stiffness, perivascular adipose (PVAT) mediated-arterial stiffening and PVAT advanced glycation end-products (AGE) accumulation. Aortic pulse wave velocity (aPWV) and intrinsic mechanical stiffness, two measures of arterial stiffness, were asses...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.08.003
更新日期：2017-10-15 00:00:00
abstract：:Whereas biological rhythms are now fairly well documented in young healthy adults, reports in elderly are relatively few for obvious reasons, including the difficulty of setting groups matched in age, sociological and professional background, medical history, and not in need of specific medication. Aging may modify on...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(96)00161-1
更新日期：1997-07-01 00:00:00
abstract：:Diseases of the elderly, including neurodegenerative and cardiovascular disorders and cancer, may develop through the accumulation of "hits" composed of genetic and epigenetic risk factors. The "iceberg" buildup of these hits over time may exceed the tolerance threshold of a particular tissue, thus precipitating disea...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(96)00156-8
更新日期：1997-07-01 00:00:00
abstract：:There is currently no test to directly and easily measure dynamic balance during walking in old adults. We examined the idea that distance of beam walking with and without cognitive dual-tasking could detect age differences in dynamic balance. Healthy old (n = 16, 71.2 y) and young (n = 20, 22.0 y) volunteers walked 3...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2018.10.016
更新日期：2018-12-01 00:00:00
abstract：:We have developed a simian virus 40 (SV40) T-antigen immortalized human cell line, 1MR90-D305.2H4 (IDH4), in which the expression of T-antigen is controlled by the mouse mammary tumor virus (MMTV) promoter and thus regulated by steroids such as dexamethasone. Studies on the regulation of proliferation by T-antigen led...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(92)90003-i
更新日期：1992-09-01 00:00:00
abstract：:Apoptosis plays an important role in atrophy and sarcopenia in skeletal muscle. Recent evidence suggests that insufficient heat shock proteins (HSPs) may contribute to apoptosis and muscle wasting. In addition, long-term caloric restriction (CR) and lifelong wheel running exercise (WR) with CR provide significant prot...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.06.007
更新日期：2015-09-01 00:00:00
abstract：:Exercise training has been associated with the attenuation of cardiovascular impairment after menopause. This study aimed to compare central and peripheral blood pressure and aortic pulse wave reflection in sedentary and trained (aerobic exercise in the water) hypertensive postmenopausal women. Hypertensive postmenopa...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111146
更新日期：2021-01-01 00:00:00
abstract：:The correlation between serum levels of pituitary and thyroid hormones and the activity of two antioxidant enzymes (AOE), catalase (CAT) and superoxide dismutase (SOD), in different immune and nonimmune organs of young and old rats was investigated. Serum levels of growth hormone (GH), prolactin (Prl), thyroid-stimula...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(94)00053-0
更新日期：1995-03-01 00:00:00
abstract：:Accumulation of oxidative stress-induced damage in brain tissue plays an important role in the pathogenesis of normal aging and neurodegenerative diseases. Neuronal oxidative damage typically increases with age in humans, and also in the invertebrate and vertebrate model species most commonly used in aging research. B...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2006.08.004
更新日期：2006-11-01 00:00:00
abstract：:Mitochondrial superoxide production is an important source of reactive oxygen species in cells, and may cause or contribute to ageing and the diseases of ageing. Seven major sites of superoxide production in mammalian mitochondria are known and widely accepted. In descending order of maximum capacity they are the ubiq...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2010.01.003
更新日期：2010-08-01 00:00:00
abstract：:There are three general categories of causes of the cognitive decline associated with aging: disuse, disease, and aging per se. People tend to use certain skills or abilities less with age and, thus, those skills decline due to the disuse. Physical illnesses tend to increase with age, which will tend to compromise cog...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/0531-5565(94)00066-c
更新日期：1995-05-01 00:00:00
