Abstract:
:Mouse models have been widely used in the research of human diseases. Aging, just as cancer, is influenced by the interaction of various genetic and environmental factors. Currently, aging could be induced by many mechanism, including telomere dysfunction, oxidase stress, DNA damage and epigenetic changes. Many of these genetic pathways are also shared by aging and cancer. The mouse models generated to study these pathways might manifest either aging or cancer phenotypes, sometimes both, which in deed has worked as a good model system in understanding the correlation between aging and cancer. Here, we reviewed these mouse models that were generated to model aging or cancer. These mouse models might help us put those related pathways in context and discover essential interactions in cancer and aging regulation.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Li H,Wei C,Zhou R,Wang B,Zhang Y,Shao C,Luo Ydoi
10.1016/j.exger.2019.03.002subject
Has Abstractpub_date
2019-06-01 00:00:00pages
88-94eissn
0531-5565issn
1873-6815pii
S0531-5565(18)30669-7journal_volume
120pub_type
杂志文章,评审abstract::The essentiality of zinc for humans was recognized only 40 years ago. Zinc deficiency was suspected to occur in Iranian patients with growth retardation, hypogonadism in males, hepato-splenomegaly, rough and dry skin, geophagia and severe iron deficiency anemia. Later we documented zinc deficiency in similar patients ...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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doi:10.1016/j.exger.2004.03.036
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2019.110679
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2004.08.007
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journal_title:Experimental gerontology
pub_type: 临床试验,杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2003.08.003
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(90)90020-3
更新日期:1990-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2004.07.002
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journal_title:Experimental gerontology
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doi:10.1016/j.exger.2018.04.003
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2012.06.009
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2021.111245
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.02.027
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1016/s0531-5565(00)00157-1
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2005.10.010
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.10.005
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