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Mechanical and non-mechanical functions of Dystrophin can prevent cardiac abnormalities in Drosophila.

Abstract：

:Dystrophin-deficiency causes cardiomyopathies and shortens the life expectancy of Duchenne and Becker muscular dystrophy patients. Restoring Dystrophin expression in the heart by gene transfer is a promising avenue to explore as a therapy. Truncated Dystrophin gene constructs have been engineered and shown to alleviate dystrophic skeletal muscle disease, but their potential in preventing the development of cardiomyopathy is not fully understood. In the present study, we found that either the mechanical or the signaling functions of Dystrophin were able to reduce the dilated heart phenotype of Dystrophin mutants in a Drosophila model. Our data suggest that Dystrophin retains some function in fly cardiomyocytes in the absence of a predicted mechanical link to the cytoskeleton. Interestingly, cardiac-specific manipulation of nitric oxide synthase expression also modulates cardiac function, which can in part be reversed by loss of Dystrophin function, further implying a signaling role of Dystrophin in the heart. These findings suggest that the signaling functions of Dystrophin protein are able to ameliorate the dilated cardiomyopathy, and thus might help to improve heart muscle function in micro-Dystrophin-based gene therapy approaches.

journal_name

Exp Gerontol

journal_title

Experimental gerontology

authors

Taghli-Lamallem O,Jagla K,Chamberlain JS,Bodmer R

doi

10.1016/j.exger.2013.10.015

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

26-34

eissn

0531-5565

issn

1873-6815

pii

S0531-5565(13)00319-7

journal_volume

49

pub_type

杂志文章

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