Abstract:
:The aging process is known to be regulated by specific genes in various organisms, including yeast, the nematode C. elegans, fruitflies and mice. To explore the novel genes involved in aging process, we applied cDNA microarray technology to a replicative senescence model of human dermal fibroblasts (HDF). Eighty-four genes, including inflammatory genes, cell cycle regulatory genes, cytoskeletal genes, and metabolic genes were found to show more than two fold expressional differences in young and old fibroblasts. Furthermore, 31 genes were confirmed to be up- or down-regulated during replicative senescence by semi-quantitative RT-PCR. The overexpressions of several genes including CD36, putative lymphocyte G0/G1 switch gene (G0S2), tumor protein D52-like 1 (TPD52L1), chemokine (C-X-C motif) ligand 6, myxovirus resistant gene 1 (MX1), and the down-regulation of the immunoglobulin superfamily containing leucine-rich repeat (ISLR), neurotrimin, insulin-like growth factor 2 associated protein (IGF2A), and apoptosis-related RNA binding protein (NAPOR3) were newly identified. These results suggest that fibroblasts show the deregulation of various cellular processes, such as inflammatory response, mitosis, cell adhesion, transport, signal transduction, and metabolism during replicative senescence.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Yoon IK,Kim HK,Kim YK,Song IH,Kim W,Kim S,Baek SH,Kim JH,Kim JRdoi
10.1016/j.exger.2004.07.002keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
1369-78issue
9eissn
0531-5565issn
1873-6815pii
S0531-5565(04)00221-9journal_volume
39pub_type
杂志文章abstract::To determine whether age-related differences in body weight loss in hyperthyroidism could be related to caloric intake, the body weight and food consumption of Fischer 344 male rats were monitored every other day for four weeks. Six-month-old (young) rats were compared to 16-month-old rats (intermediate age) and 25-mo...
journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.exger.2018.06.007
更新日期:2018-09-01 00:00:00
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journal_title:Experimental gerontology
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doi:10.1016/j.exger.2007.03.005
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2004.01.012
更新日期:2004-05-01 00:00:00
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(00)00157-1
更新日期:2000-12-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2006.07.006
更新日期:2006-11-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.08.008
更新日期:2014-10-01 00:00:00
abstract::Engineering of fetal tissue has a high potential for the treatment of acute and chronic wounds of the skin in humans as these cells have high expansion capacity under simple culture conditions and one organ donation can produce Master Cell Banks which can fabricate over 900 million biological bandages (9 x 12cm). In a...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2008.11.004
更新日期:2009-03-01 00:00:00
abstract::Mitochondrial dysfunction is involved in the loss of muscle featuring both aging and cancer cachexia (CC). Whether mitochondrial quality control (MQC) is altered in skeletal myocytes of old patients with CC is unclear. The present investigation therefore sought to preliminarily characterize MQC pathways in muscle of o...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2016.10.003
更新日期:2017-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(96)00032-0
更新日期:1997-01-01 00:00:00
abstract::Mitochondria play a critical role in the life of the cell as they control their metabolic rate, energy production and cell death. Mitochondria have long been appreciated as causative to aging. The age-associated respiratory chain deficiency is typically unevenly distributed and affects only a subset of cells in variou...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2008.05.006
更新日期:2009-01-01 00:00:00
abstract::The Senescence-Accelerated Mouse (SAM) strains are unique and appropriate models for genetic studies on aging because the SAMP strains have an "accelerated senescence" phenotype for which the SAMR strains are controls, and each SAMP strain has a strain-specific age-associated disorder. Furthermore, because they have g...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(96)00060-5
更新日期:1997-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.05.010
更新日期:2014-09-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.03.004
更新日期:2014-07-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.06.008
更新日期:2013-09-01 00:00:00
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journal_title:Experimental gerontology
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doi:10.1016/j.exger.2015.08.011
更新日期:2015-10-01 00:00:00
abstract::Telomerase plays an important role in cellular proliferation capacity and survival under conditions of stress. A large part of this protective function is due to telomere capping and maintenance. Thus it contributes to cellular immortality in stem cells and cancer. Recently, evidence has accumulated that telomerase ca...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2009.05.004
更新日期:2009-08-01 00:00:00
abstract::Reproductive senescence occurs in all female mammals with resultant changes in numerous body functional systems and several important features may be species-specific. Those features that appear to parallel human menopause and aging include general similarity of hormone profiles across the menopausal transition, progr...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2005.10.010
更新日期:2006-02-01 00:00:00
abstract::Average life expectancy at birth is a rough measure of the span of healthy, productive life--the functional life span. In the developed countries average life expectancies at birth now range from 76-79 years, six to nine years less than the limit of about 85 years imposed by aging. Aging is the accumulation of changes...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(97)00059-4
更新日期:1998-01-01 00:00:00
abstract::Calorie restriction (CR) and a reduced growth hormone (GH) signal affect insulin sensitivity and lifespan in mammals in a similar manner. We investigated the effects of CR and moderate inhibition of GH on glucose-stimulated activation of insulin signaling and the expression of genes related to fat metabolism in white ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2009.07.002
更新日期:2009-10-01 00:00:00
abstract::As the analysis of apoptosis is of interest in many basic and clinically oriented investigations, we intend to give a brief overview on the recently most-used methods for detection of apoptotic cells, including the study of morphology, analysis of DNA degradation, DNA end-labeling techniques, flow cytometric analysis,...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(98)00031-x
更新日期:1998-09-01 00:00:00
abstract::Diabetic peripheral neuropathy (DPN) is associated with peripheral arterial disease and endothelial dysfunction. We investigated the effect of exercise training on the measures of superficial femoral artery (SFA) and neuropathic symptoms in patients with DPN. In a randomized-controlled trial, 31 volunteers with establ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2019.110799
更新日期:2020-03-01 00:00:00
abstract::Young rhesus monkey females (Macaca mulatta) demonstrate the well-defined circadian rhythm in activity of erythrocyte SOD with maximum at 10.00 h and minimum at 22.00 h. However, neither GSH-Px nor GR demonstrated any significant circadian changes, contrastingly to SOD. The diurnal changes in the SOD activity tightly ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2006.04.006
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:To assess the 24-h endogenous secretory growth hormone (GH) profile and serum insulin-like growth factor-I (IGF-I) response to exogenous recombinant human growth hormone (rhGH) in a patient with Werner's syndrome. DESIGN:Blood sampling every 20 min for 24 h followed by three daily injections of growth hormon...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(96)00031-9
更新日期:1996-09-01 00:00:00