Abstract:
:Mitochondria play a critical role in the life of the cell as they control their metabolic rate, energy production and cell death. Mitochondria have long been appreciated as causative to aging. The age-associated respiratory chain deficiency is typically unevenly distributed and affects only a subset of cells in various human tissues, such as heart, skeletal muscle, colonic crypts and neurons. Studies of mtDNA mutator mice has provided the first direct evidence that accelerating the mtDNA mutation rate can result in premature aging, consistent with the view that loss of mitochondrial function is a major causal factor in aging. New, controversial data have arisen from the studies on molecular mechanisms that drive premature aging in mtDNA mutator mice. Our results suggest that the accumulation of high levels of mtDNA point mutations, causing amino acid substitutions, combined with their clonal expansion is probably the main driving force behind premature aging in mtDNA mutator mice.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Kukat A,Trifunovic Adoi
10.1016/j.exger.2008.05.006subject
Has Abstractpub_date
2009-01-01 00:00:00pages
101-5issue
1-2eissn
0531-5565issn
1873-6815pii
S0531-5565(08)00154-Xjournal_volume
44pub_type
杂志文章,评审abstract::Diabetes mellitus (DM) is considered a risk factor for the development of Alzheimer disease (AD); however, how DM favors evolution of AD is still insufficiently understood. Hyperglycemia in DM is associated to an increase in mitochondrial reactive oxygen species (ROS) generation, as well as damage of hippocampal cells...
journal_title:Experimental gerontology
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2012.06.015
更新日期:2012-12-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/0531-5565(92)90012-o
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2007.12.010
更新日期:2008-04-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(89)90014-4
更新日期:1989-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.09.005
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(00)00210-2
更新日期:2001-01-01 00:00:00
abstract::Alterations in heparan sulfate, the principal glycosaminoglycan species in glomerular basement membrane, have been proposed as contributory to permeability changes in nephropathic disorders. In the present study, the extent of sulfation of glycosaminoglycans isolated from pronase digests of human glomerular basement m...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(83)90023-2
更新日期:1983-01-01 00:00:00
abstract::SAMP8 mice exhibit multiple metabolic characteristics associated with age, and it is a suitable candidate for researching aging associated metabolic dysfunction. OBJECTIVES:We aimed to 1) explore how key metabolic markers will be altered in both liver and adipose tissue with aging in SAMP8 mice; and 2) how the combin...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.03.017
更新日期:2017-07-01 00:00:00
abstract::Age- and sex-associated differences in lipid peroxidation (LPO), and total sialic acid content (TSA) in response to abuse of drugs have been reported both in humans and experimental animals. However, no data on the influence of gender and age on these parameters have been reported for methionine-enkephalin (MENK). In ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(02)00118-3
更新日期:2002-12-01 00:00:00
abstract::One of the most remarkable life history traits of many species of eusocial insects is the extraordinary longevity of their queens, with the recorded life span of some individuals exceeding 30 years. Surprisingly, little research has been conducted on either the proximate or ultimate questions concerning what factors f...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(00)00237-0
更新日期:2001-04-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.exger.2018.04.022
更新日期:2018-07-15 00:00:00
abstract::Aging is a physiological process characterized by an age-progressive decline in intrinsic physiological functions, with an increased risk of developing chronic metabolic conditions, such as insulin resistance and diabetes. Furthermore, from a physiopathological point of view, several authors describe an association be...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2019.03.011
更新日期:2019-07-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.01.012
更新日期:2013-03-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(82)90025-0
更新日期:1982-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.exger.2015.06.018
更新日期:2015-10-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2007.03.005
更新日期:2007-07-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(02)00137-7
更新日期:2002-10-01 00:00:00
abstract::Injured skeletal muscle generally regenerates less efficiently with age, but little is understood about the effects of ageing on the very early inflammatory and neovascular events in the muscle repair process. This study used a total of 174 whole muscle grafts transplanted within and between young and old mice to anal...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2008.02.005
更新日期:2008-06-01 00:00:00
abstract::Threat-related changes in postural control and their associations with changes in emotional and cognitive states are influenced by postural threat experience, however, limited work has explored individuals' capacity to adapt threat-related responses over longer periods of threat exposure. This study examined the effec...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2019.04.015
更新日期:2019-07-15 00:00:00
abstract:OBJECTIVES:The present study investigated whether the performance on executive function tasks of patients with type 2 diabetes mellitus (T2DM) is as impaired as that of Alzheimer's disease (AD) patients and to compare their performance with that of a group of cognitively healthy older adults. We also investigated wheth...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2016.07.013
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:The impact of regular exercise habits at middle-age on muscle mass and function at old age remains inconclusive. While regular exercise likely represents a primary source of health-enhancing physical activity (PA), the physical demand of occupation needs to be considered. Additionally, PA level at old age sh...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2021.111259
更新日期:2021-01-28 00:00:00
abstract::Non-insulin dependent diabetes mellitus (NIDDM) has been associated with a number of physiological consequences including neuropathy, retinopathy and incidence of vascular disease. Recently, several authors reviewed studies that suggested that NIDDM is associated with cognitive impairments leading to a higher incidenc...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(03)00153-0
更新日期:2003-09-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2006.10.012
更新日期:2007-05-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2010.10.004
更新日期:2011-01-01 00:00:00
abstract::Methionine restriction (MR) extends lifespan across different species. The main responses of rodent models to MR are well-documented in adipose tissue (AT) and liver, which have reduced mass and improved insulin sensitivity, respectively. Recently, molecular mechanisms that improve healthspan have been identified in b...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2017.01.012
更新日期:2017-08-01 00:00:00