Abstract：
:Caloric restriction (CR) without malnutrition in mice and rats reduces the incidence of spontaneous tumors and delays their appearance while increasing maximum life span. These results depend largely on CR per se, and not on low intakes of fat or other nutrients. Although most studies have tested CR imposed early in life, CR started in midadulthood also retards cancer and aging. The way(s) by which CR impedes cancers remain unclear, but possibilities include less cellular oxidative damage, retarded immunologic aging, hormonal changes, less energy available for cell proliferation, reduced exposure to dietary carcinogens and promoters, enhanced DNA repair, and less carcinogen activation. Far less is known about the relationship between caloric intake and cancer incidence in humans; however, recent findings suggest a positive association for certain cancers.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Weindruch Rdoi
10.1016/0531-5565(92)90012-okeywords:
subject
Has Abstractpub_date
1992-09-01 00:00:00pages
575-81issue
5-6eissn
0531-5565issn
1873-6815journal_volume
27pub_type
杂志文章,评审abstract：:We previously reported that lysophosphatidylcholine (LPC) is a mediator of endothelial dysfunction in the expression of adhesion molecules (AMs) during aging. This study aimed at investigating the effects of betaine on LPC-related expression of AMs and the molecular modulation of nuclear factor-κB (NF-κB) activation i...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.02.024
更新日期：2013-05-01 00:00:00
abstract：:Initial velocity of GABA uptake in hypothalamic synaptosomes has been measured in aged animals as a function of both sodium and GABA concentration and compared to previous studies in young animals. The data give good fit to the model found previously to give minimal best fit to control data. Thus it appears that aging...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(83)90005-0
更新日期：1983-01-01 00:00:00
abstract：:The hypotheses were: HISS-dependent insulin resistance (HDIR) accounts for insulin resistance that occurs with aging; HDIR is the initiating metabolic defect that leads progressively to type 2 diabetes and the metabolic syndrome; a synergistic antioxidant cocktail in chow confers protection against HDIR, subsequent sy...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2008.04.013
更新日期：2008-08-01 00:00:00
abstract：:Age-related hearing loss (AHL) is a progressive neurodegenerative disease that is largely silent in its initial stages. There is no sensitive blood biomarker for diagnosis or early detection of AHL. MicroRNAs (miRNAs or miRs) are abundant and highly stable in blood, and have been recently described as powerful circula...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.01.009
更新日期：2016-04-01 00:00:00
abstract：:Type 2 diabetes is associated with progressive beta-cell failure manifest as a decline in insulin secretion and increasing hyperglycemia. A growing body of evidence suggests that beta-cell failure in type 2 diabetes correlates with the formation of pancreatic islet amyloid deposits, indicating that islet amyloid may h...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(03)00004-4
更新日期：2003-04-01 00:00:00
abstract：:Coronary heart disease is less prevalent in pre-menopausal women than in men, but increases at the onset of menopause. This delay is due to estrogen protective effects. The rise of cholesterolemia is one of the main risk factors for coronary disease. Since 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) is the ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.10.014
更新日期：2010-02-01 00:00:00
abstract：:The aim of this study was to compare voluntary and involuntary force generating capacity of the triceps surae muscles in healthy young and older adult participants during isometric and isokinetic contractions. Ultrasound was used to measure medial gastrocnemius (MG) fascicle length during maximal voluntary isometric c...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.07.007
更新日期：2013-11-01 00:00:00
abstract：:Changes associated with the age-related decline of physiological functions, and their relation with mortality rates, are thoroughly being investigated in the aging research field. We used the Mediterranean fruit fly Ceratitis capitata, largely studied by biodemographers, as a model for functional senescence studies. T...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2012.04.001
更新日期：2012-06-01 00:00:00
abstract：:Telomeres are specialised structures located at the end of eukaryotic chromosomes, that get short during progressive cell divisions. Therefore, telomere may be an indicator of the mitotic history of a cell and it is also a determining factor for the residual cell life span. One mechanism, compensating for the telomere...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(03)00058-5
更新日期：2003-06-01 00:00:00
abstract：:We investigated the telomere lengths of individual cell types in lingual mucosa using an improved tissue quantitative fluorescence in situ hybridization (Q-FISH) method. Our tissue Q-FISH method compensates for partially cut nuclei in a tissue section by using the telomere:centromere ratio (TCR). We normalized our TCR...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2008.06.001
更新日期：2008-09-01 00:00:00
abstract：:Intracellular Ca(2+) signaling is important to perfusion pressure related arterial reactivity and to vascular disorders including hypertension, angina and ischemic stroke. We have recently shown that advancing-age leads to calcium signaling adaptations in mesenteric arterial myocytes from C57 BL/6 mice [Corsso, C.D., ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2008.10.007
更新日期：2009-03-01 00:00:00
abstract：:The interrelationship between muscle strength, motor unit (MU) number, and age is poorly understood, and in this study we sought to determine whether age-related differences in muscle strength are moderated by estimates of functioning MU number and size. Eighteen older adults (OA; 67 ± 1.20 years) and 24 young adults ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.06.008
更新日期：2013-09-01 00:00:00
abstract：:In order to establish the role of calcitonin (CT) in postmenopausal bone loss, we studied CT metabolism in 25 pre- and postmenopausal women. Postmenopausal women presented a highly significant reduction of CT basal levels compared to premenopausal females (p less than 0.01). Also, production rates of CT in osteoporoti...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(90)90072-a
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVES:To investigate whether the implementation of a multifactorial falls intervention in nursing homes is cost-beneficial and alleviates the professional workload. DESIGN:A comprehensive quantitative model was developed to calculate the impact of investments in multifactorial falls prevention in nursing homes in...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111173
更新日期：2021-01-01 00:00:00
abstract：:Stem cells are located throughout the adult body of higher organisms, supporting a continuous renewal and repair of tissues. Unique abilities of stem cells are self-renewal and multipotential differentiation. It is, therefore, of critical importance for an organism to maintain and control quantity and quality of stem ...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2005.07.006
更新日期：2005-12-01 00:00:00
abstract：:Aging associates with a decline of physiological functions, including the function of the nervous and the immune system. These aged-related changes occur in various degrees in different members of a mouse outbred population. Accordingly, we have proposed a model of premature immunosenescence in mice, based on the demo...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(01)00190-5
更新日期：2002-01-01 00:00:00
abstract：:The aim of the present study was to compare the effects of water-based aerobic training and water-based resistance training on muscular strength and cardiorespiratory fitness in older women. Sixty-nine individuals were randomized into the following three groups: the water-based aerobic training (WA, n = 23) group, the...
journal_title：Experimental gerontology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.exger.2018.04.022
更新日期：2018-07-15 00:00:00
abstract：:Reproductive senescence occurs in all female mammals with resultant changes in numerous body functional systems and several important features may be species-specific. Those features that appear to parallel human menopause and aging include general similarity of hormone profiles across the menopausal transition, progr...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2005.10.010
更新日期：2006-02-01 00:00:00
abstract：:Calorie restriction (CR) and a reduced growth hormone (GH) signal affect insulin sensitivity and lifespan in mammals in a similar manner. We investigated the effects of CR and moderate inhibition of GH on glucose-stimulated activation of insulin signaling and the expression of genes related to fat metabolism in white ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.07.002
更新日期：2009-10-01 00:00:00
abstract：:We investigated the effects of angiotensin-converting enzyme (ACE) inhibition and aerobic physical training on the heart of old female rats (82-wk-old) submitted to premature ovarian failure (10-wk.-old). We used different approaches: morphology and function by echocardiography, reactivity of the coronary bed and left...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.04.003
更新日期：2018-08-01 00:00:00
abstract：:The aim of this study was to compare the functional and structural changes in similarly identified neurons of the small parietal ganglion in 56 molluscs (Lymnaea stagnalis) of two age groups: adult (10-12 months) and old (20-22 months). No age changes were found in the values of membrane potential, resistance of the n...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(95)00008-5
更新日期：1995-09-01 00:00:00
abstract：:Aromatase inhibitors have become the standard of care for the adjuvant treatment of postmenopausal, hormone-sensitive breast cancer. Meanwhile, more and more breast cancer patients who are treated with aromatase inhibitors as adjuvant therapies often experience arthralgias and musculoskeletal aching, in some cases, ha...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.03.003
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVE:Senescent patients exhibit an elevated perioperative risk for cardiac dysfunction, hemodynamic depression and subsequent cardiac death compared to young patients. Despite the fact that a growing proportion of cardiac surgery patients are octogenarians, cardioplegic regimes remain comparable across patients of...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.04.012
更新日期：2015-07-01 00:00:00
abstract：:Ageing is defined as the loss of ability to maintain cellular homeostasis of an organism associated with the free radical-elicited oxidative damage to cellular macromolecules. The aim of this study was to evaluate the efficacy of epigallocatechin-3-gallate (EGCG), the key component of green tea catechins on attenuatin...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2007.10.017
更新日期：2008-03-01 00:00:00
abstract：:It is well established that the proliferative potential of the liver declines with aging. Epidermal growth factor (EGF)-stimulated DNA synthesis is reduced in hepatocytes from aged rats relative to young rats, and this reduction correlates with diminished activation of the extracellular signal-regulated kinase (ERK) p...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(02)00239-5
更新日期：2003-04-01 00:00:00
abstract：BACKGROUND:An intermission in the training routine, in which older adults refrain from regular structured exercise, may have deleterious effects on muscle performance and bioelectric phase angle (PhA), which is a predictive marker for cellular integrity. PURPOSE:To determine the effects of a 2-week detraining period o...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111175
更新日期：2021-02-01 00:00:00
abstract：:We previously demonstrated that in vitro stimulated splenic B cells from senescent mice are deficient in production of multiple class switch isotypes, class switch recombination (CSR), induction of the E2A-encoded transcription factor E47, and activation-induced cytidine deaminase (AID) which is necessary for CSR and ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2006.09.003
更新日期：2007-03-01 00:00:00
abstract：:The observation that long-lived and relatively healthy animals can be obtained by simple genetic manipulation prompts the search for chemical compounds that have similar effects. Since aging is the most important risk factor for many socially and economically important diseases, the discovery of a wide range of chemic...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2008.08.049
更新日期：2008-10-01 00:00:00
abstract：:Sex hormones are known to help maintaining the cognitive ability in male and female rats. Hypogonadism results in the reduction of the dendritic spines of central neurons which is believed to undermine memory and cognition and cause fatigue and poor concentration. In our previous studies, we have reported age-related ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.06.010
更新日期：2014-09-01 00:00:00
abstract：:Ascorbic acid decreases from age-group I to II in Kidney, skeletal muscle, and increases in the Pancreas of female. There is no significant change in the Pancreas of male toad. There is an increase in the ascorbic acid content from age group II to III except in the Pancreas of females, where there is a decline of the ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(84)90011-1
更新日期：1984-01-01 00:00:00
