Abstract：
:The intrinsic contractile properties of papillary muscles isolated from female Wistar rats during post-natal development were examined. In addition, the myocardial responsiveness to certain inotropic interventions was studied. In muscles from 60-day-old animals, the velocity of shortening was markedly greater than muscles from animals greater than or equal to 180 days old. These findings occurred in the presence and absence of added norepinephrine or calcium and over a wide range of contraction frequency. No major age-related differences in responsiveness to the various inotropic agents was observed. Isometric tension was significantly higher in muscles from animals greater than or equal to 180 days of age when compared to 60-day-old rats. Thus, post-natal development profoundly affects the intrinsic contractile state of cardiac muscle, with the force of contraction increasing and the speed of shortening decreasing as animals age.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Capasso JM,Sonnenblick EHdoi
10.1016/0531-5565(82)90025-0subject
Has Abstractpub_date
1982-01-01 00:00:00pages
195-203issue
3eissn
0531-5565issn
1873-6815pii
0531-5565(82)90025-0journal_volume
17pub_type
杂志文章abstract：:A colony of male Lakeview Golden (LVG) Syrian hamsters has been maintained for the last nine years as a source of various tissues for cellular aging studies. Observations on this colony also yielded data on survival time and physical and pathological manifestations of aging in this strain. Based on 150 spontaneous dea...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(90)90032-w
更新日期：1990-01-01 00:00:00
abstract：:Aging is associated with changes in lymphocyte subsets and unexplained HLA-DR upregulation on T-lymphocytes. We further investigated this activation, by measuring early (CD69), middle (CD25), and late (HLA-DR) T-lymphocyte activation markers on CD3+ lymphocytes, across subjects (20-100 years) together with serum tumor...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(98)00058-8
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:Longitudinal studies on sleep duration and grip strength decline are limited. This study aimed to evaluate the associations of baseline sleep duration with follow-up grip strength and grip strength changeover time among a large sample of middle-aged and older Chinese. METHODS:Data from China Health and Reti...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2018.01.009
更新日期：2018-03-01 00:00:00
abstract：:Hospitalization may induce a decrease of muscle strength and muscle mass in older patients due to physical inactivity, malnutrition and diseases, negatively affecting health outcome. We aimed to examine the literature on change in muscle strength and muscle mass in older patients during hospitalization. A literature s...
journal_title：Experimental gerontology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.exger.2017.03.006
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVES:There is a scarcity of data on the association between mild cognitive impairment (MCI) and falls, especially from low- and middle-income countries (LMICs) where 70% of all older adults reside. Thus, we investigated the association between MCI and fall-related injury among older adults residing in six LMICs (...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111222
更新日期：2020-12-29 00:00:00
abstract：:Aging is associated with changes in several metabolic pathways affecting liver function including the adaptive unfolded protein response (UPR). On the other hand, exercise training has been shown to exert beneficial effects on metabolism in the liver and exercise training has been reported to affect hepatic UPR. PGC-1...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.08.006
更新日期：2017-11-01 00:00:00
abstract：:The study examined the influence of sex on the alterations occurring with ageing in rat lymph node (LN) T cell compartment. In female and male rats the decrease in LN T cell counts was followed by a shift in CD4+/CD8+ T cell ratio towards CD8+ T cells, which was more prominent in males than in females. With ageing, in...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111140
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Several studies reported an association between concentrations of serum uric acid and cognitive function, but the evidence is contradictory. It is known that uric acid is associated with cardiovascular diseases, especially among women. Stratifying by sex and history of cardiovascular disease may clarify whet...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.04.017
更新日期：2016-08-01 00:00:00
abstract：:Increased lifespan can be associated with greater resistance to many different stressors, most notably thermal stress. Such hormetic effects have also been found in C. elegans where short-term exposure to heat lengthens the lifespan. Genetic investigations have been carried out using mutation perturbations in a single...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2012.05.005
更新日期：2012-08-01 00:00:00
abstract：:Natural killer (NK) cells play an important role in controlling several viral diseases. Our previous studies demonstrated an age-dependent susceptibility to mousepox due to defective NK cell responses and trafficking. However, the mechanisms that underlie the age-related impairment in NK cell migration have yet to be ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.06.021
更新日期：2017-10-01 00:00:00
abstract：:Like the weather, many people talk about aging, but no one seems able to do anything about it. This implacability derives, at least in part, from our inability to provide a conceptual base from which analytic insight might derive. The emerging field of nonlinear thermodynamics presents a new view of the universe. It r...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(86)90039-2
更新日期：1986-01-01 00:00:00
abstract：:Impaired tolerance to ischemia-reperfusion in older hearts may stem in part from alterations in purine catabolism, impacting on maintenance of energy state and protective signaling via extracellular adenosine. We characterized effects of aging on normoxic and post-ischemic purine metabolism in hearts from young (2-4 m...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2003.08.003
更新日期：2003-10-01 00:00:00
abstract：:During aging declining maximum force capacity with more or less unchanged fatigability is observed with the underlying mechanisms still not fully understood. Therefore, we compared morphology and function of skeletal muscles between different age groups. Changes in high-energy phosphate turnover (PCr, Pi and pH) and m...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.02.016
更新日期：2015-05-01 00:00:00
abstract：:As recently reported, it is possible to detect and quantify the amount of the deleted human mitochondrial DNA (mtDNA) in whole blood, platelets and peripheral blood mononuclear cells using real-time PCR. The aim of this study was to identify the cell types in human blood carrying the 4977 bp deleted mtDNA and their ac...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2003.10.011
更新日期：2004-02-01 00:00:00
abstract：:Muscle wasting diseases are gradually increasing with the increase in global life expectancy. This study was designed to evaluate the efficacy of HIM-CHX, a herbal combination of Boswellia serrata, Cissus quadrangularis, and Withania somnifera, on Sarcopenia. The effects of HIM-CHX on parameters such as muscle mass, g...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.110663
更新日期：2019-10-01 00:00:00
abstract：:Stiffening of large elastic arteries with age increases the risk of cardiovascular diseases (CVD), but the underlying mechanisms are incompletely understood. We investigated the role of mitochondrial quality control (QC, i.e., mitophagy and biogenesis) in arterial stiffening with aging. In C57BL6 mice, aging was assoc...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.07.008
更新日期：2014-10-01 00:00:00
abstract：:As a major intracellular source of reactive oxygen species (ROS), mitochondria are involved in aging and lifespan regulation. Using the yeast chronological aging model, researchers have identified conserved signaling pathways that affect lifespan by modulating mitochondrial functions. Caloric restriction and a genetic...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2011.08.007
更新日期：2011-11-01 00:00:00
abstract：:In the present study we investigated the age-related response of Phytohemaglutinin (PHA)-activated S phase human lymphocytes isolated from peripheral blood from donors of four different age groups, namely young (25-30 years), mid-aged (40-45 years), senior (60-65 years) and elderly (80-95 years) on the induction of th...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2003.12.014
更新日期：2004-04-01 00:00:00
abstract：:Homeostenosis (i.e. decline in stress resistance and resilience with age) is a fundamental notion of the biogerontology and physiology of aging. Stressful situations typically challenge metabolic homeostasis and the capacity to recover from a stress-induced metabolic disorder might be particularly compromised in senes...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.08.021
更新日期：2018-02-01 00:00:00
abstract：:Aging in a given individual can be characterized by the number of deficits (symptoms, signs, laboratory abnormalities, disabilities) that they accumulate. The number of accumulated deficits, more than their nature, well characterizes health status in individuals - the proportion of deficits present in an individual to...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2012.06.015
更新日期：2012-12-01 00:00:00
abstract：:Centenarians are people who escaped from major common diseases, including cancer, and reached the extreme limits of human life-span. The analysis of demographic data indicates that cancer incidence and mortality show a levelling off around the age of 85-90 years, and suggests that oldest old people and centenarians ar...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(02)00137-7
更新日期：2002-10-01 00:00:00
abstract：:Brain aging, Alzheimer disease and stroke share common elements of deficits in calcium regulation, declines in mitochondrial function, increases in generation of reactive oxygen species (ROS), accumulated damage from ROS and immune system dysfunction. The problem is to distinguish less significant side reactions, such...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(00)00121-2
更新日期：2000-12-01 00:00:00
abstract：:A series of theoretical analyses of mortality were performed on recent data for Mediterranean fruit flies (Ceratitus capitata). Best fit computations were performed using the Marquardt-Levenburg technique on: 1) the classic Gompertz model, 2) the Johnson-Mehl-Avrami (JMA) model from chemical kinetics theory, which is ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(94)90051-5
更新日期：1994-03-01 00:00:00
abstract：:Dystrophin-deficiency causes cardiomyopathies and shortens the life expectancy of Duchenne and Becker muscular dystrophy patients. Restoring Dystrophin expression in the heart by gene transfer is a promising avenue to explore as a therapy. Truncated Dystrophin gene constructs have been engineered and shown to alleviat...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.10.015
更新日期：2014-01-01 00:00:00
abstract：:The dependent elderly are widely considered to be at higher risk of nutritional problems. Suboptimal micronutrient intake might put the elderly, especially those living in nursing homes, at high risk of morbidity. So far, no public authority, except for the Israel Ministry of Health, has issued particular recommendati...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.09.009
更新日期：2016-11-01 00:00:00
abstract：:To understand the mechanism of aging at the cellular level, cellular senescence has been extensively studied as an experimental model of aging in vitro. Although several hypotheses have been proposed for the mechanism of cellular senescence, none of them could give a comprehensive framework to the mechanism. In this s...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(98)00008-4
更新日期：1998-08-01 00:00:00
abstract：:Calorie restriction (CR) and a reduced growth hormone (GH) signal affect insulin sensitivity and lifespan in mammals in a similar manner. We investigated the effects of CR and moderate inhibition of GH on glucose-stimulated activation of insulin signaling and the expression of genes related to fat metabolism in white ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.07.002
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:The proportion of elderly individuals is growing and the prevalence of chronic kidney disease (CKD) among elderly people undergoing cardiac surgery is increasing constantly. The aim of this study was to determine the influence of different degrees of preoperative renal dysfunction on postoperative outcomes i...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.01.012
更新日期：2013-03-01 00:00:00
abstract：:Physical activity may help to prevent or delay brain atrophy. Numerous studies have shown associations between physical activity and age-related changes in the brain. However, most of these studies involved self-reported physical activity, not objectively measured physical activity. Therefore, the aim of this study wa...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.12.011
更新日期：2015-02-01 00:00:00
abstract：:To test if the adrenocortical axis of the rat loses sensitivity to negative feedback control during aging, we examined corticosterone secretion under basal, stressed and post-stress conditions in young and in aged Fisher male rats. We find no age-related change in the speed or magnitude of the stress response or in th...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(83)90051-7
更新日期：1983-01-01 00:00:00
