Abstract：
:The study examined the influence of sex on the alterations occurring with ageing in rat lymph node (LN) T cell compartment. In female and male rats the decrease in LN T cell counts was followed by a shift in CD4+/CD8+ T cell ratio towards CD8+ T cells, which was more prominent in males than in females. With ageing, in both major LN T cell subpopulations naïve (recent thymic emigrants and mature naïve cells) to memory/activated T cell ratio shifted to the side of memory/activated cells in female, and particularly in male rats. The frequency of regulatory CD25+Foxp3+ cells increased among LN CD4+/CD8+ T cells with ageing, reflecting, at least partly, an enhanced conversion of effector T cells into regulatory cells. This was also more prominent in male rats. The more prounounced increase in LN oxidative damage and the expression levels of proinflammatory cytokines in male rats with ageing, most likely contributed to the greater frequency of proinflammatory, replicatively senescent CD28- cells expressing CD11b (innate cell marker), among T cells of old male rats compared with age-matched females. The increase in LN oxidation/proinflammatory state with ageing was also consistent with the accumulation of exhausted PD-1high cells among T lymphocytes, particularly prominent among CD8+ T cells from male rats. Finally, by calculating a summary score for the key ageing-relevant parameters (an ageing index), a faster development of the deleterious changes in the T cell compartment occurring with ageing was confirmed in male rat LNs. Additionally, the study pointed to indices of LN T cell compartment ageing which correlate with those in peripheral blood.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Nacka-Aleksić M,Stojić-Vukanić Z,Pilipović I,Blagojević V,Kotur-Stevuljević J,Leposavić Gdoi
10.1016/j.exger.2020.111140subject
Has Abstractpub_date
2020-12-01 00:00:00pages
111140eissn
0531-5565issn
1873-6815pii
S0531-5565(20)30488-5journal_volume
142pub_type
杂志文章abstract：BACKGROUND:Physical activity and sedentary behavior are modifiable risk factors for non-communicable disease and healthy ageing, however the majority of older adults remain insufficiently active. Digital behavior change interventions (DBCI) have the potential to reach many older adults to promote physical activity and ...
journal_title：Experimental gerontology
pub_type： 杂志文章,meta分析
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abstract：:Neuroblastoma cells (N1E-115) were used as models of transient (T) and long-lasting (L) Ca++ channels. The whole cell version of the patch clamp technique was used to measure inward Ca++ currents, and the fluorescent indicator, Fura-2, was used to measure changes in intracellular Ca++. Cells were cultured and selected...
journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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abstract：:Numerous trials have shown that physical activity and exercise training have beneficial effects in general older populations. However, few have studied its effectiveness among people with dementia. The aim of this systematic review is to examine the efficacy of trials using a rigorous randomised, controlled design and...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.10.002
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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journal_title：Experimental gerontology
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doi：10.1016/j.exger.2013.08.003
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journal_title：Experimental gerontology
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doi：10.1016/j.exger.2020.110972
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.08.021
更新日期：2018-02-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(01)00133-4
更新日期：2001-09-01 00:00:00
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journal_title：Experimental gerontology
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doi：10.1016/j.exger.2019.01.015
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pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00176-5
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.05.008
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journal_title：Experimental gerontology
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doi：10.1016/j.exger.2014.02.009
更新日期：2014-08-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.05.015
更新日期：2016-09-01 00:00:00
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journal_title：Experimental gerontology
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pub_type： 杂志文章
doi：10.1016/j.exger.2019.04.015
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journal_title：Experimental gerontology
pub_type： 杂志文章
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.12.011
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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abstract：:The accuracy of protein synthesis has been measured in extracts from human diploid fibroblasts of different ages. Extracts were supplied with purified mRNA for the coat protein of the cowpea variant of tobacco mosaic virus (CcTMV), which lacks codons for cysteine and methionine. The presence of 35S-cysteine in CcTMV c...
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