当前位置： SCI文献检索 > EXPERIMENTAL GERONTOLOGY期刊下所有文献 > Altered mitochondrial quality control signaling in muscle of old gastric cancer patients with cachexia.

Altered mitochondrial quality control signaling in muscle of old gastric cancer patients with cachexia.

Abstract：

:Mitochondrial dysfunction is involved in the loss of muscle featuring both aging and cancer cachexia (CC). Whether mitochondrial quality control (MQC) is altered in skeletal myocytes of old patients with CC is unclear. The present investigation therefore sought to preliminarily characterize MQC pathways in muscle of old gastric cancer patients with cachexia. The study followed a case-control cross-sectional design. Intraoperative biopsies of the rectus abdominis muscle were obtained from 18 patients with gastric adenocarcinoma (nine with CC and nine non-cachectic) and nine controls, and assayed for the expression of a set of MQC mediators. The mitofusin 2 expression was reduced in cancer patients compared with controls, independent of CC. Fission protein 1 was instead up-regulated in CC patients relative to the other groups. The mitophagy regulators PTEN-induced putative kinase 1 and Parkin were both down-regulated in cancer patients compared with controls. The ratio between the protein content of the lipidated and non-lipidated forms of microtubule-associated protein 1 light chain 3B was lower in CC patients relative to controls and non-cachectic cancer patients. Finally, the expression of autophagy-associated protein 7, lysosome-associated membrane protein 2, peroxisome proliferator-activated receptor-γ coactivator-1α, and mitochondrial transcription factor A was unvarying among groups. Collectively, our findings indicate that, in old patients with gastric cancer, cachexia is associated with derangements of the muscular MQC axis at several checkpoints: mitochondrial dynamics, mitochondrial tagging for disposal, and mitophagy signaling. Further investigations are needed to corroborate these preliminary findings and determine whether MQC pathways may become target for future interventions.

journal_name

Exp Gerontol

journal_title

Experimental gerontology

authors

Marzetti E,Lorenzi M,Landi F,Picca A,Rosa F,Tanganelli F,Galli M,Doglietto GB,Pacelli F,Cesari M,Bernabei R,Calvani R,Bossola M

doi

10.1016/j.exger.2016.10.003

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

92-99

issue

Pt A

eissn

0531-5565

issn

1873-6815

pii

S0531-5565(16)30259-5

journal_volume

pub_type

杂志文章

在线工具

Altered mitochondrial quality control signaling in muscle of old gastric cancer patients with cachexia.