Abstract:
:Calorie restriction (CR) may affect glucose tolerance via modulation of the insulin action in skeletal muscle. The present study investigated the effect of CR initiated at middle age in rats bearing glucose intolerance, in comparison with CR at a younger age. Male F344 rats at 2.5 and 18months (mo) of age were fed ad libitum (AL) or 30% CR diets for 4-4.5mo, subjected to glucose tolerance testing, and then sacrificed 15min after intraperitoneal glucose or saline injection to evaluate glucose-stimulated insulin response and subsequent activation of insulin signaling molecules. The protein abundance of phosphorylated (p) insulin receptors, p-Akt, and p-atypical PKC and the membrane fraction of glucose transporter 4 in quadriceps femoris muscle (QFM) were analyzed by EIA or immunoblotting. CR initiated either at young or middle age improved glucose tolerance with a lower serum insulin response to glucose. However, middle-aged CR did not improve aging-related impairments in insulin signaling in QFM. The present results emphasized the possibilities of CR activation of an insulin-independent mechanism in skeletal muscle and also of the involvement of non-muscle tissues in glucose uptake.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Park S,Komatsu T,Hayashi H,Yamaza H,Chiba T,Higami Y,Kuramoto K,Shimokawa Idoi
10.1016/j.exger.2006.06.055subject
Has Abstractpub_date
2006-09-01 00:00:00pages
837-45issue
9eissn
0531-5565issn
1873-6815pii
S0531-5565(06)00242-7journal_volume
41pub_type
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journal_title:Experimental gerontology
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doi:10.1016/j.exger.2015.06.003
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journal_title:Experimental gerontology
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doi:10.1016/j.exger.2004.03.036
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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doi:10.1016/j.exger.2014.06.017
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doi:10.1016/0531-5565(95)00008-5
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journal_title:Experimental gerontology
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doi:10.1016/0531-5565(83)90005-0
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journal_title:Experimental gerontology
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doi:10.1016/j.exger.2016.12.003
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(98)00031-x
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2004.07.002
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pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.04.007
更新日期:2013-08-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/0531-5565(91)90011-a
更新日期:1991-01-01 00:00:00
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
pub_type: 杂志文章
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更新日期:1982-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.10.006
更新日期:2014-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2019.110657
更新日期:2019-10-01 00:00:00