HISS-dependent insulin resistance (HDIR) in aged rats is associated with adiposity, progresses to syndrome X, and is attenuated by a unique antioxidant cocktail.

abstract：:Although galanin has been shown to increase GLUT4 expression in the cardiac muscle of rats, there is no literature available about the effect of GalR1 on GLUT4 expression in the cardiac muscle of type 2 diabetic rats. The aim of this study was to determine whether intracerebroventricular injection of GalR1 agonist M61...

journal_title：Experimental gerontology

authors： Fang P,Shi M,Zhu Y,Zhang Z,Bo P

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Physical activity and sedentary behavior are modifiable risk factors for non-communicable disease and healthy ageing, however the majority of older adults remain insufficiently active. Digital behavior change interventions (DBCI) have the potential to reach many older adults to promote physical activity and ...

journal_title：Experimental gerontology

authors： Stockwell S,Schofield P,Fisher A,Firth J,Jackson SE,Stubbs B,Smith L

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:The impact of regular exercise habits at middle-age on muscle mass and function at old age remains inconclusive. While regular exercise likely represents a primary source of health-enhancing physical activity (PA), the physical demand of occupation needs to be considered. Additionally, PA level at old age sh...

journal_title：Experimental gerontology

authors： Edholm P,Veen J,Kadi F,Nilsson A

更新日期：2021-01-28 00:00:00

abstract：BACKGROUND:Critically ill intensive care patients are subjected to controlled mechanical ventilation (CMV) which has an important association in triggering the impaired muscle function and the consequent delayed weaning from the respirator. AIM:The main aim of this study was to measure the effects of age and CMV over ...

journal_title：Experimental gerontology

authors： Cacciani N,Ogilvie H,Larsson L

更新日期：2014-11-01 00:00:00

abstract：:The leucine-rich repeat transmembrane 3 (LRRTM3) has been defined as a positional and functional candidate gene for Alzheimer's disease. Recently, four novel variants (rs16923760, rs1925608, rs1925609 and rs10997477) within LRRTM3 were reported to be associated with late-onset Alzheimer's disease (LOAD) in Caucasians....

journal_title：Experimental gerontology

authors： Wang J,Yu JT,Jiang T,Tan MS,Wang HF,Tan L,Hu N,Sun L,Zhang W,Tan L

更新日期：2014-04-01 00:00:00

abstract：:Aging adipose tissues (ATs) manifest reduced vascularity and increased hypoxia and inflammation that contribute to local and systemic metabolic dysfunction. However, the mechanisms that underlie these age-related changes are incompletely understood. In this study, we sought to examine insulin-stimulated vasodilation a...

journal_title：Experimental gerontology

authors： Islam MT,Henson GD,Machin DR,Bramwell RC,Donato AJ,Lesniewski LA

更新日期：2020-12-01 00:00:00

abstract：:Aging is a physiological process characterized by an age-progressive decline in intrinsic physiological functions, with an increased risk of developing chronic metabolic conditions, such as insulin resistance and diabetes. Furthermore, from a physiopathological point of view, several authors describe an association be...

journal_title：Experimental gerontology

authors： Zoico E,Rizzatti V,Policastro G,Tebon M,Darra E,Rossi AP,Mazzali G,Fantin F,Zamboni M

更新日期：2019-07-01 00:00:00

abstract：:Menopause is associated with a decline in overall health in women. One health aspect impacted is glucose metabolism. As women experience menopause, their metabolism declines dramatically. The current study addressed the influence of ovarian somatic cells on the improvement of metabolic health through transplantations ...

journal_title：Experimental gerontology

authors： Tyler KA,Habermehl TL,Mason JB

更新日期：2019-10-15 00:00:00

abstract：:Several papers reported in recent years on a change in the age population distribution of the circulating erythrocytes in old mice, rats, rabbits, and humans. The results indicate the presence of a chronologically younger cell population in old animals and humans. The cells are typically lower in density and larger. I...

journal_title：Experimental gerontology

authors： Danon D,Bologna NB,Gavendo S

更新日期：1992-01-01 00:00:00

abstract：:Female mammals undergo natural fluctuations in sex steroid hormone levels throughout life. These fluctuations span from early development, to cyclic changes associated with the menstrual or estrous cycle and pregnancy, to marked hormone flux during perimenopause, and a final decline at reproductive senescence. While t...

journal_title：Experimental gerontology

authors： Koebele SV,Bimonte-Nelson HA

更新日期：2017-08-01 00:00:00

abstract：:The antioxidant 2-mercaptoethylamine (MEA) was added to the culture medium of WI-38 cells throughout their lifespan. MEA concentrations of 0.5 microM, 5 microM and 50 microM were used. The presence of 5 microM or 50 microM MEA decreased the fraction of rapidly dividing cells and slightly reduced cell density at conflu...

journal_title：Experimental gerontology

authors： Golczewski JA

更新日期：1984-01-01 00:00:00

abstract：:Rats of Albino Oxford (AO) strain in our animal facility exhibit a longer average healthy life span than rats of Dark Agouit (DA) strain. Since chronic activation of macrophages contributes to chronic low level inflammation common in older age, elucidation of the changes in middle-aged rats could be useful in preventi...

journal_title：Experimental gerontology

authors： Stanojević S,Ćuruvija I,Blagojević V,Petrović R,Vujić V,Dimitrijević M

更新日期：2016-12-01 00:00:00

abstract：:We develop a theoretical model from an energetic viewpoint for unraveling the entangled effects of metabolic and biosynthetic rates on oxidative cellular damage accumulation during animal's growth, and test the model by experiments in hornworms. The theoretical consideration suggests that most of the cellular damages ...

journal_title：Experimental gerontology

authors： Amunugama K,Jiao L,Olbricht GR,Walker C,Huang YW,Nam PK,Hou C

更新日期：2016-09-01 00:00:00

abstract：:Studying the changes of serum N-glycome during mouse aging is beneficial to explore the molecular basis behind the alterations reported in human. However, such studies remainscarce and lack some information such as sialylation due to the method limitation. Here, we introduced Bionic Glycome method to quantify the seru...

journal_title：Experimental gerontology

authors： Han J,Pan Y,Qin W,Gu Y,Xu X,Zhao R,Sha J,Zhang R,Gu J,Ren S

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Sarcopenic obesity is a combination of both sarcopenia and obesity, which potentiate each other and maximize the negative influences of each, such as physical disability, morbidity, or even mortality. OBJECTIVES:To describe the criteria used to identify people with sarcopenic obesity and the components of t...

journal_title：Experimental gerontology

authors： Yin YH,Liu JYW,Välimäki M

更新日期：2020-07-01 00:00:00

abstract：:It is well established that the proliferative potential of the liver declines with aging. Epidermal growth factor (EGF)-stimulated DNA synthesis is reduced in hepatocytes from aged rats relative to young rats, and this reduction correlates with diminished activation of the extracellular signal-regulated kinase (ERK) p...

journal_title：Experimental gerontology

authors： Ikeyama S,Kokkonen G,Martindale JL,Wang XT,Gorospe M,Holbrook NJ

更新日期：2003-04-01 00:00:00

abstract：:In order to clarify immunogenetic markers contributing to successful aging, HLA and cytokine gene profiles were analyzed in healthy elderly Bulgarians. Family segregation analysis was performed to define combined effect of haplotypes and immunophenotype profiles. The results of this study did not reveal any statistica...

journal_title：Experimental gerontology

authors： Naumova E,Mihaylova A,Ivanova M,Michailova S,Penkova K,Baltadjieva D

更新日期：2004-04-01 00:00:00

abstract：:A decline in instrumental activities of daily living has been described as the earliest functional deficit in patients with neurodegenerative disease. It embraces specific competencies such as: "recalling the date and telephone calls, orienting to new places, remembering the location of objects at home, understanding ...

journal_title：Experimental gerontology

authors： Amanzio M,D'Agata F,Palermo S,Rubino E,Zucca M,Galati A,Pinessi L,Castellano G,Rainero I

更新日期：2016-10-01 00:00:00

abstract：:Since the reproducible production of microscope objectives was enabled by the lens calculations of Ernst Abbe in 1872, various attempts have been made to further increase the resolution of light microscopes. Apart from the improvements on the optical side, especially the introduction of fluorescence methods, the use o...

journal_title：Experimental gerontology

authors： Malkusch W,Bauch H,Schäfer L

更新日期：2001-07-01 00:00:00

abstract：:Replicative senescence appears after a finite number of cell divisions. After proliferation has ceased, senescent cells remain viable for long periods and metabolic modifications are observed such as lipofuscin accumulation. In order to understand this phenomenon, we examined the emergence of subcellular modifications...

journal_title：Experimental gerontology

authors： Gerland LM,Peyrol S,Lallemand C,Branche R,Magaud JP,Ffrench M

更新日期：2003-08-01 00:00:00

abstract：:Centenarians are people who escaped from major common diseases, including cancer, and reached the extreme limits of human life-span. The analysis of demographic data indicates that cancer incidence and mortality show a levelling off around the age of 85-90 years, and suggests that oldest old people and centenarians ar...

journal_title：Experimental gerontology

authors： Bonafè M,Barbi C,Storci G,Salvioli S,Capri M,Olivieri F,Valensin S,Monti D,Gonos ES,De Benedictis G,Franceschi C

更新日期：2002-10-01 00:00:00

abstract：:Recent deep sequencing studies on T-cell receptor (TCR) repertoire have provided robust data to characterize diversity of T-cell immune responsiveness to a wide variety of peptide antigens, including viral and tumor antigens. The human TCR repertoire declines with age, but this decline has not been fully investigated ...

journal_title：Experimental gerontology

authors： Yoshida K,Cologne JB,Cordova K,Misumi M,Yamaoka M,Kyoizumi S,Hayashi T,Robins H,Kusunoki Y

更新日期：2017-10-01 00:00:00

abstract：:The age-associated decline in the regenerative abilities of mesenchymal stem cells (MSCs) may be due to age-related changes in reduction in number, intrinsic properties of MSCs and extrinsic factors of the extracellular environment (the stem cell niche). The effect of age on the efficacy of MSC transplantation on rege...

journal_title：Experimental gerontology

authors： Iohara K,Murakami M,Nakata K,Nakashima M

更新日期：2014-04-01 00:00:00

abstract：:We investigated the effect of resistance training on irisin expression with improvement in muscle strength and function in aged mice and human. In the mice study, 19 months old male C57BL/6 mice were randomly assigned into two groups; control group and resistance exercise group. Ladder climbing exercise with tail weig...

journal_title：Experimental gerontology

authors： Kim HJ,So B,Choi M,Kang D,Song W

更新日期：2015-10-01 00:00:00

abstract：:The purpose of this study was to examine the combined cardiorespiratory and cerebrovascular responses to head-up tilt (HUT) in young and older trained and untrained humans following moderate-duration exercise. Middle cerebral artery blood flow velocity (MCAv; transcranial Doppler ultrasound), blood pressure (BP; Finom...

journal_title：Experimental gerontology

authors： Murrell CJ,Cotter JD,George K,Shave R,Wilson L,Thomas K,Williams MJ,Ainslie PN

更新日期：2011-01-01 00:00:00

abstract：:Engineering of fetal tissue has a high potential for the treatment of acute and chronic wounds of the skin in humans as these cells have high expansion capacity under simple culture conditions and one organ donation can produce Master Cell Banks which can fabricate over 900 million biological bandages (9 x 12cm). In a...

journal_title：Experimental gerontology

authors： Ramelet AA,Hirt-Burri N,Raffoul W,Scaletta C,Pioletti DP,Offord E,Mansourian R,Applegate LA

更新日期：2009-03-01 00:00:00

abstract：:We have analyzed birth records from the International Species Inventory System database of zoo animals to describe patterns of fertility as a function of age in birds and mammals. Unlike age at death, fertility in captive populations is partly controlled by animal keepers depending on availability of space and potenti...

journal_title：Experimental gerontology

authors： Ricklefs RE,Scheuerlein A,Cohen A

更新日期：2003-07-01 00:00:00

abstract：:The concept that lifespan is a function of the capacity to withstand extrinsic stress is very old. In concordance with this, long-lived individuals often have increased resistance against a variety of stresses throughout life. Genes underlying the stress response may therefore have the ability to affect lifespan. The ...

journal_title：Experimental gerontology

authors： Vermeulen CJ,Loeschcke V

更新日期：2007-03-01 00:00:00

abstract：:Even though Alzheimer's disease (AD) is the most common cause of dementia, the mechanisms governing the establishment and progression of the disease remain largely unknown. Here, we investigated the implication of the neuroprotective protein BMI1 (B lymphoma Mo-MLV insertion region 1 homolog) in AD and the possibility...

journal_title：Experimental gerontology

authors： Tzekaki EE,Papaspyropoulos A,Tsolaki M,Lazarou E,Kozori M,Pantazaki ΑA

更新日期：2021-02-01 00:00:00

abstract：:The gangliosides in human diploid fibroblasts--TIG-1, TIG-7, and IMR-90--were analysed at different cell densities at early and late passages to clarify the relationship between age and cell density dependent changes of the gangliosides. In early passages, the ganglioside concentrations increased with increase in cell...

journal_title：Experimental gerontology

authors： Ohsawa T

更新日期：1989-01-01 00:00:00