Abstract:
:The concept that lifespan is a function of the capacity to withstand extrinsic stress is very old. In concordance with this, long-lived individuals often have increased resistance against a variety of stresses throughout life. Genes underlying the stress response may therefore have the ability to affect lifespan. The progress in modern genetic techniques has allowed researchers to test this idea. The general stress response involves the expression of stress proteins, such as chaperones and antioxidative proteins, downregulation of genes involved in energy metabolism and the release of protective substances. Do these same changes in patterns of expression have the ability to mitigate ageing and prolong lifespan? It appears that parts of this response indeed are also associated with extended longevity, whereas some elements are not, due to their high cost or long-term deleterious consequences. Here we briefly review the state of the art of research on ageing and longevity in the model organism Drosophila, with focus on the role of the general stress response. We will conclude by contemplating some of the implications of the findings in this research and will suggest several directions for future research.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Vermeulen CJ,Loeschcke Vdoi
10.1016/j.exger.2006.09.014subject
Has Abstractpub_date
2007-03-01 00:00:00pages
153-9issue
3eissn
0531-5565issn
1873-6815pii
S0531-5565(06)00294-4journal_volume
42pub_type
杂志文章,评审abstract::Plantar-flexor muscles are key muscles in the control of postural sway. Older fallers present lower maximal plantar-flexor performance than older non-fallers; however, the mechanisms underlying this motor impairment remain to be elucidated. This study aimed to determine whether muscular and neural factors are both inv...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2018.09.011
更新日期:2018-10-02 00:00:00
abstract::Permethrin is a synthetic pyrethroid extensively used as anti-woodworm agent and for indoor and outdoor pest control. The main route of human exposure is through fruit, vegetable and milk intake. Low dosage exposure to permethrin during neonatal brain development (from postnatal day 6 to postnatal day 21) leads to dop...
journal_title:Experimental gerontology
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.01.001
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journal_title:Experimental gerontology
pub_type: 杂志文章,随机对照试验
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更新日期:2013-08-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2009.10.005
更新日期:2010-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2019.01.011
更新日期:2019-04-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2010.05.004
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2012.06.015
更新日期:2012-12-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
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更新日期:1995-09-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.05.020
更新日期:2017-10-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(83)90023-2
更新日期:1983-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2019.110780
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(90)90059-b
更新日期:1990-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2008.05.003
更新日期:2009-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.111173
更新日期:2021-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(00)00199-6
更新日期:2001-02-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(03)00058-5
更新日期:2003-06-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.01.011
更新日期:2017-04-01 00:00:00
abstract::Histopathological and autofluorescence investigations were carried out to study lipofuscin pigment accumulation in various age groups of mice. Qualitative studies revealed an increase of lipofuscin pigment accumulation in old animals. Quantitative studies showed a significant increase in the percentage of pigmented ne...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(82)90041-9
更新日期:1982-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
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更新日期:2000-09-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2016.07.013
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2015.08.011
更新日期:2015-10-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.03.004
更新日期:2014-07-01 00:00:00
abstract::This study aimed to analyze the effects of resistance training associated with testosterone administration in the neuromuscular junction (NMJ) postsynaptic region of different skeletal muscle types of aged rats. Wistar rats were divided into: SEI - 20-months-old control, SEF - 24-months-old control, T - 20-months-old ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.08.018
更新日期:2017-11-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 历史文章,杂志文章
doi:10.1016/j.exger.2012.02.004
更新日期:2013-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(85)90038-5
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(95)00014-3
更新日期:1995-11-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(02)00239-5
更新日期:2003-04-01 00:00:00
abstract::Alzheimer's disease (AD) is characterized by the accumulation and aggregation of misfolded proteins. The presence of misfolded proteins in the endoplasmic reticulum (ER) triggers a cellular stress response called the unfolded protein response (UPR). Previously, we have shown that the UPR is activated in AD neurons. In...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2006.01.013
更新日期:2006-04-01 00:00:00